Cocculine: Uses, Composition, Administration, Presentation, Mechanism of Action and Warnings

It is a homeopathic medicine traditionally used for the treatment of motion sickness.

The homeopathic medicine cocculine relieves the symptoms of motion sickness, such as nausea, vomiting, dizziness and cold sweats, in adults and children over 2 years of age.

These fast dissolving, non-drowsy tablets are convenient to take as no water is needed.

Every year, more than two million people visit a doctor for dizziness, and untold numbers suffer from vertigo. Although patients complain of similar symptoms, there are different treatments available.

An otolaryngologist will explore the causes behind the balance distress by examining the ears, nose, and throat to make a diagnosis.

Many times, cases of dizziness are mild and treatable disorders, but severe cases warrant medical attention.

What is the difference between dizziness, vertigo, and nausea?

Some people describe a balance problem by saying that they feel dizzy, lightheaded, fatigued, or insecure. This feeling of imbalance is sometimes caused by an inner ear problem.

Patients explain that their surroundings are spinning or spinning. Vertigo can also be caused by problems in the inner ear.

Motion sickness is a common medical problem associated with travel. Some people experience fatigue, nausea, or vomiting when they travel by plane, car, boat, or an amusement park attraction.

Motion sickness is generally only a minor annoyance and does not signify any serious medical illness, but some travelers are disabled. Some even suffer symptoms for a few days after the trip.

How does the body keep its balance?

Dizziness, vertigo, and motion sickness are related to a sense of balance.

Researchers in aeronautical and space medicine call this sense spatial orientation, because it tells the brain where the body is “in space,” in which direction it is pointing, in which direction it is moving, and whether it is turning or stopping.

Symptoms of dizziness and nausea appear when the central nervous system receives conflicting messages from the other four systems. For example, suppose you are going through a storm and your plane is being tossed about by turbulence in the air.

But your eyes don’t detect all this movement because all you see is the inside of the plane.

Then your brain receives messages that do not match each other. You could become “sick of the air.” Or, to use a true medical condition as an example, suppose you have inner ear damage on only one side due to a head injury or infection.

The damaged inner ear does not send the same signals as the healthy ear.

Composition of cocculine

The granules in the 4-channel dilution dose tube:

  • Cocculus indicus 4 CH (0,0025 ml).
  • Nux Vornica 4 CH (0.0025 ml).
  • Tabacum 4 CH (0,0025 ml).
  • 4 CH oil (0.0025 ml).
  • Excipients (substance other than the active ingredient in the medicine ): lactose, sucrose.

Cocculine dosage

Adults and children from 2 years:

They should take 2 tablets every hour up to 6 times a day. For best results, dissolve under tongue.

Preparation prior to transport: take 2 tablets on the eve of the trip and take 1 tablet on the day of the trip. If symptoms occur, follow the general recommended dosage.

Presentation of the cocculine

It comes in the form of granules in 6 single-dose containers.

This medication is also available in a box of 60 quick-dissolving tablets.

Mechanism of action of cocculine

Cocculine directly antagonizes the GABA A receptor channel, which is a ligand-activated ion channel primarily related to the passage of chloride ions through the cell membrane.

The cocculine reduces the conductance through the channel by reducing not only the opening frequency but also the mean opening time.

Cocculine also antagonizes GABA C receptors (also called GABA A-Rho receptors) but the result of this action is not known.

The GABA C receptor is also linked to chloride channels, with different physiological and pharmacological properties.

In contrast to the rapid and transient responses elicited by GABA A receptors, GABA C receptors mediate slow and sustained responses.


In large doses it is a powerful poison, causing unconsciousness, delirium, seizures, gastroenteritis, and stimulation of the respiratory center, followed by paralysis, from which death sometimes occurs.

Pregnancy and Breastfeeding

In the absence of experimental and clinical data, and as a precautionary measure, the use of this medicine should be avoided during pregnancy and lactation.

Terms of conservation of the cocculine

  • This medicine has a shelf life of 5 years.
  • Keep in a cool place.