Cocculine: Uses, Composition, Administration, Presentation, Mechanism of Action and Warnings

It is a homeopathic medicine traditionally used for the treatment of motion sickness.

The homeopathic medicine cocculine relieves the symptoms of motion sickness, such as nausea, vomiting, dizziness, and cold sweats, in adults and children over two years of age.

These fast-dissolving, non-drowsy tablets are convenient to take as no water is needed.

More than two million people visit a doctor for dizziness every year, and untold numbers suffer from vertigo. Although patients complain of similar symptoms, there are different treatments available.

An otolaryngologist will explore the causes behind the balance distress by examining the ears, nose, and throat to diagnose.

Many times, cases of dizziness are mild and treatable disorders, but severe cases warrant medical attention.

What is the difference between dizziness, vertigo, and nausea?

Some people describe a balance problem by saying they feel dizzy, lightheaded, tired, or insecure. An inner ear problem sometimes causes this feeling of imbalance.


Patients explain that their surroundings are spinning or spinning. Problems in the inner ear can also cause vertigo.

Motion sickness is a common medical problem associated with travel. Some people experience fatigue, nausea, or vomiting when traveling by plane, car, boat, or an amusement park attraction.

Motion sickness is generally only a minor annoyance and does not signify any serious medical illness, but some travelers are disabled. Some even suffer symptoms for a few days after the trip.

How does the body keep its balance?

Dizziness, vertigo, and motion sickness are related to a sense of balance.

Researchers in aeronautical and space medicine call this sense spatial orientation because it tells the brain where the body is “in space,” in which direction it is pointing, which direction it is moving, and whether it is turning or stopping.

Symptoms of dizziness and nausea appear when the central nervous system receives conflicting messages from the other four systems. For example, suppose you are going through a storm, and your plane is being tossed about by turbulence in the air.

But your eyes don’t detect all this movement because all you see is the inside of the plane.

Then your brain receives messages that do not match each other. You could become “sick of the air.” Or, to use an actual medical condition as an example, suppose you have inner ear damage on only one side due to a head injury or infection.

The damaged inner ear does not send the same signals as the healthy ear.

Composition of cocculine

The granules in the 4-channel dilution dose tube:

  • Cocculus indicus 4 CH (0,0025 ml).
  • Nux Vomica 4 CH (0.0025 ml).
  • Tabacum 4 CH (0,0025 ml).
  • 4 CH oil (0.0025 ml).
  • Excipients (substance other than the active ingredient in the medicine ): lactose, sucrose.

Cocculine dosage

Adults and children from 2 years:

They should take two tablets every hour up to 6 times a day. For best results, dissolve under the tongue.

Preparation before transport: take two tablets on the eve of the trip and take one tablet on the day. If symptoms occur, follow the general recommended dosage.

Presentation of the cocculine

It comes in the form of granules in 6 single-dose containers.

This medication is also available in a box of 60 quick-dissolving tablets.

Mechanism of action of cocculine

Cocculine directly antagonizes the GABA A receptor channel, a ligand-activated ion channel primarily related to the passage of chloride ions through the cell membrane.

The cocculine reduces the conductance through the channel by reducing the opening frequency and the mean opening time.

Cocculine also antagonizes GABA C receptors (also called GABA A-Rho receptors), but the result of this action is not known.

The GABA C receptor is also linked to chloride channels, with different physiological and pharmacological properties.

In contrast to the rapid and transient responses elicited by GABA A receptors, GABA C receptors mediate slow and sustained responses.


In large doses, it is a potent poison, causing unconsciousness, delirium, seizures, gastroenteritis, and stimulation of the respiratory center, followed by paralysis, from which death sometimes occurs.

Pregnancy and Breastfeeding

In the absence of experimental and clinical data, and as a precautionary measure, this medicine should be avoided during pregnancy and lactation.

Terms of conservation of the cocculine

  • This medicine has a shelf life of 5 years.
  • Keep in a cool place.