Ziped: Formula, Presentation, Indications, Mechanism of Action, Dosage, Side Effects, Warnings, Contraindications and Interactions

Zinc is a natural mineral and is very important for growth and for the development and health of body tissues.

The active component of zipped is Zinc sulfate .

Ziped is used to treat and prevent zinc deficiencies. In addition to this, zinc sulfate, an active element in ziped, is used as a supplement in oral rehydration, in order to reduce the duration and severity of diarrhea .

Chemical formula of the ziped

  • ZnSO4.


The presentation of ziped is an oral solution in a 60 ml bottle.

Ziped indications

This medicine is a mineral that is indicated in the treatment of pediatric patients with persistent acute diarrhea and to prevent relapses, it is also used in the treatment of zinc deficiency .

Mechanism of action

Ziped contains zinc, which is a mineral that helps in the differentiation process of cells, as well as in the proper functioning of the intestinal epithelium. Participates in the restoration of injured tissues, and improves the absorption of sodium and water.

It interferes in the main intracellular pathways of the secretion of ions at the intestinal level that are involved in diarrhea.

Participates in resistance to infections; its deficiency compromises multiple aspects of the immune system, from the integrity of the skin and mucous membranes as a barrier, to genetic regulation within the lymphocytes.

Therefore, its deficiency is associated with an increased risk of gastrointestinal infections, adverse effects on the structure and function of the gastrointestinal tract.


In children older than 6 months: the administration of 1 teaspoon (5 cc) of zinc sulfate (20 mg) a day, before or after food is recommended.

In children under 6 months: the administration of 1 ml of zinc sulfate oral drops is recommended, once a day, before or after food.

In children over 12 years of age and adults: the administration of 1 zinc sulfate capsule (20 mg) a day is recommended, before or after food.

You should take this medication by mouth as directed by your doctor.

Milk, bran, grains, or cereals should be avoided within 2 hours of taking this medicine.

Side effects of ziped

Side effects of ziped include:

  • Sickness.
  • Vomiting
  • Gastric irritation.
  • Elevation of serum alkaline phosphate, amylase, and lipase that can return to their high normal level within 1 to 2 years of treatment.
  • Neurological impairment.

The physician should be notified if any of these effects persist or become severe.

Tell your doctor right away if any of these unlikely but serious side effects occur: fever, chills, sore throat, mouth sores, unusual tiredness, weakness.

Although its incidence is rare, high doses of zinc can cause hematological abnormalities such as microcytic and sideroblastic anemias, they can contribute to cardiac abnormalities such as tachycardia, cardiac arrest, and secondary heart block due to secondary plasma copper deficiency.

They can also cause gastrointestinal disorders such as dyspepsia , epigastric pain, nausea, gastric erosions.

Ziped warnings and contraindications

The following conditions are contraindicated with this drug. Check with your doctor if you have any of the following:

  • Conditions: inadequate amount of copper.
  • Allergies: to zinc and zinc sulfate.

This medicine should be used with caution if you are pregnant or nursing and consult a doctor before using this medicine.

Avoid taking this drug with foods that are high in calcium or phosphorus, which can make it harder for the body to absorb zinc sulfate.

Ziped interactions

This product may decrease the absorption of other medications such as tetracycline antibiotics like doxycycline, minocycline, bisphosphonates like alendronate, and quinolone antibiotics like levofloxacin.

Foods that are high in calcium, phosphorus, or phytates (found in bran, whole wheat bread) can reduce the absorption of zinc.

Zinc absorption is reduced by 50% with the consumption of coffee.

The doses of ziped should be separated from the doses of these foods and medications.

Ask your doctor about how long to wait between doses of other medications and ask for help finding a dosing schedule that works for all foods and medications.