Ziped: Formula, Presentation, Indications, Mechanism of Action, Dosage, Side Effects, Warnings, Contraindications and Interactions

Zinc is a natural mineral and is very important for body tissues’ growth, development, and health.

The active component of zipped is Zinc sulfate.

Zipped is used to treat and prevent zinc deficiencies. In addition to this, zinc sulfate, an active element in zipped, is used as a supplement in oral rehydration to reduce the duration and severity of diarrhea.

Chemical formula of the zipped

  • ZnSO4.


The presentation of zipped is an oral solution in a 60 ml bottle.

Zipped indications

This medicine is a mineral indicated in treating pediatric patients with persistent acute diarrhea. To prevent relapses, it is also used to treat zinc deficiency.

Mechanism of action

Zipped contains zinc, a mineral that helps in the differentiation process of cells and the proper functioning of the intestinal epithelium. Participates in restoring injured tissues and improves the absorption of sodium and water.

It interferes in the main intracellular pathways of the secretion of ions at the intestinal level involved in diarrhea.


Participates in resistance to infections; its deficiency compromises multiple aspects of the immune system, from the integrity of the skin and mucous membranes as a barrier to genetic regulation within the lymphocytes.

Therefore, its deficiency is associated with an increased risk of gastrointestinal infections and adverse effects on the structure and function of the gastrointestinal tract.


In children older than six months: the administration of 1 teaspoon (5 ccs) of zinc sulfate (20 mg) a day, before or after food is recommended.

In children under six months: the administration of 1 ml of zinc sulfate oral drops is recommended once a day, before or after food.

In children over 12 years of age and adults: the administration of 1 zinc sulfate capsule (20 mg) a day is recommended, before or after food.

You should take this medication by mouth as directed by your doctor.

Milk, bran, grains, or cereals should be avoided within 2 hours of taking this medicine.

Side effects of zipped

Side effects of zipped include:

  • Sickness.
  • Vomiting
  • Gastric irritation.
  • Elevation of serum alkaline phosphate, amylase, and lipase can return to their high average level within 1 to 2 years of treatment.
  • Neurological impairment.

The physician should be notified if these effects persist or become severe.

Tell your doctor if any of these unlikely but severe side effects occur: fever, chills, sore throat, mouth sores, unusual tiredness, or weakness.

Although its incidence is rare, high doses of zinc can cause hematological abnormalities such as microcytic and sideroblastic anemias; they can contribute to cardiac abnormalities such as tachycardia, cardiac arrest, and secondary heart block secondary plasma copper deficiency.

They can also cause gastrointestinal disorders such as dyspepsia, epigastric pain, nausea, and gastric erosions.

Zipped warnings and contraindications

The following conditions are contraindicated with this drug. Check with your doctor if you have any of the following:

  • Conditions: the inadequate amount of copper.
  • Allergies: to zinc and zinc sulfate.

This medicine should be used with caution if you are pregnant or nursing, and consult a doctor before using this medicine.

Avoid taking this drug with foods high in calcium or phosphorus, making it harder for the body to absorb zinc sulfate.

Zipped interactions

This product may decrease the absorption of other medications such as tetracycline antibiotics like doxycycline, minocycline, bisphosphonates like alendronate, and quinolone antibiotics like levofloxacin.

Foods high in calcium, phosphorus, or phytates (in bran and whole wheat bread) can reduce zinc absorption.

Zinc absorption is reduced by 50% with the consumption of coffee.

The doses of zipped should be separated from the amounts of these foods and medications.

Ask your doctor about how long to wait between doses of other medications and ask for help finding a dosing schedule that works for all foods and drugs.