Dexketoprofen: Uses, Side Effects, Dosage, Interactions and Warnings

It is used to relieve mild to moderate pain associated with surgeries, muscle aches, sprains, sports injuries, painful periods, toothaches, etc.

The use of this medicine is not recommended in patients under 18 years of age.

Side effects

The side effects that are generated from the administration of dexketoprofen are:

  • Nausea and vomiting
  • Diarrhea.
  • Stomach ache.
  • Dizziness (generally rare but severe).
  • Nervousness (severe effect, you should seek immediate medical assistance if it occurs).
  • Headache.
  • Dry mouth.
  • Acne.
  • Soft spot.
  • Loss of appetite (its appearance is generally rare).
  • Sweating increased (generally its appearance is rare).

For serious side effects it is necessary to contact a doctor immediately if the patient experiences any of these symptoms on a regular basis.

Rare symptoms are generally seen in a small fraction of the population, but medical assistance is necessary.

This is not an exhaustive list of side effects. The patient should inform their physician if they experience these or any other adverse drug reaction.

How does it work

This medicine works by blocking the formation of certain chemicals in the body that are responsible for causing pain and swelling .

Start of action

The amount of time required for this drug to show its action is not clinically established. It is necessary that the patient consult his doctor for more information.

Duration of effect

The amount of time that this medicine remains active in the body depends on the patient’s body and the medical indications.

Alcohol intake under treatment

Alcohol consumption is not recommended during treatment with this medicine because of the increased risk of developing serious side effects, such as:

  • Severe gastrointestinal bleeding.
  • Dizziness
  • Fatigue.
  • Soft spot.

Habit formation

No habit-forming trends were reported with dexketoprofen consumption.

Use in pregnancy and lactation

This medication is not recommended for pregnant or breastfeeding women unless absolutely necessary.

All risks and benefits should be discussed with the doctor before using this medication.

When not to use

Dexketoprofen has some contraindications that must be taken into account when administering it.

Allergy

The use of this medicine is not recommended in patients with:

  • Known allergy to dexketoprofen.
  • Known allergy to other non-steroidal anti-inflammatory drugs (NSAIDs).
  • Allergies to any other inactive ingredients present with this medicine.

Bleeding disorder

The use of this drug is not recommended in patients with active bleeding or bleeding disorders, as it may worsen the patient’s condition.

Gastrointestinal disorders

The use of this medicine is not recommended in patients with gastrointestinal disorders such as:

  • The Crohn ‘s disease .
  • Ulcerative colitis.
  • Gastrointestinal bleeding.
  • These conditions can make your condition worse if dexketoprofen is given while they are present.

Severe heart failure

The use of this drug is not recommended in patients with severe heart failure, as it may worsen the patient’s condition.

Severe dehydration

The use of this medicine is not recommended in patients with severe dehydration caused by:

  • Vomiting
  • Diarrhea.
  • Insufficient fluid intake.

This could increase the risk of the patient’s condition getting worse.

Skin disorders

The topical forms of this medication (gel and spray) are not recommended in patients with skin disorders such as:

  • Eczema.
  • Acne .
  • Open wounds.
  • Skin lesions
  • Dermatosis.

Dosage

Missed dose

Tablet, spray and gel: If the patient misses a dose of this medicine, they should take or use the dose as soon as they remember.

If it is almost time for the next dose, you should skip the missed dose and take or use the next dose.

Doubling the dose to make up for a missed dose is not recommended.

Injection: Since this medication is administered in a hospital or clinical setting by a qualified healthcare professional, the likelihood of missing a dose is very low.

Overdose

Tablet, Spray, and Gel – Patient should seek emergency medical treatment or contact physician in case of overdose.

Injection: Because this drug is administered in a hospital setting by a qualified healthcare professional, the likelihood of an overdose is very low.

However, the doctor should initiate emergency treatment if an overdose is suspected.

Interactions

All drugs interact differently depending on the person. The patient should verify all possible interactions with their physician before starting any medication.

Interaction with other medicines

  • Methotrexate (severe interaction, the patient should consult with his doctor if he is under this treatment).
  • Warfarin (severe interaction).
  • Corticosteroids (moderate interaction but requires attention).
  • ACE inhibitors (moderate interaction).

Disease interactions

Asthma

It can have serious effects.

Therefore, the use of this medicine is not recommended in patients with a known history of NSAID-induced asthma.

If dexketoprofen is administered under this condition, the patient is at increased risk of worsening his condition.

In this case, replacement with a suitable alternative should be done under the supervision of your doctor.

Acne

Interaction with this rash and dexketoprofen can have serious consequences. This drug can cause fatal skin allergies without warning in some patients.

Signs and symptoms such as rashes, hives, fever or other allergic symptoms should be reported to the doctor without delay.

Appropriate corrective measures, dose adjustments, or replacement with a suitable alternative may be required depending on the clinical condition.

Gastrointestinal toxicity

Severe complications can occur when dexketoprofen is administered under this condition. This medicine can cause damage to the stomach, intestines, liver, etc., especially with prolonged use.

The patient should inform their doctor immediately if they develop any symptoms such as chronic indigestion, blood in the stool or vomit, etc., during the treatment.

Appropriate dose adjustments or replacement with an appropriate alternative may be required depending on the clinical picture.

Fluid retention and edema

Interactions under this condition can create serious difficulties. This medicine can cause fluid retention and edema in some patients.

Close monitoring of blood pressure, electrolyte levels, and cardiac function may be required depending on the clinical picture.

In some cases, appropriate dose adjustments or replacement with a suitable alternative may be necessary depending on the clinical situation.

This is not an exhaustive list of possible drug interactions.

The patient should consult his doctor about all possible interactions of the medications he is taking.

General instructions

Tablet: This medicine should be taken exactly as directed by your doctor. Greater or lesser amounts than recommended should not be administered.

It is necessary to ensure that the course of treatment is complete. The use of this medicine should not be stopped without consulting a doctor.

Injection: This medication should only be administered by a qualified healthcare professional. The patient must follow all the instructions given by his doctor.

Spray and gel: This medicine should be used exactly as prescribed by the doctor. It should not be used in greater or lesser amounts than recommended.

Warnings for specific population

Pregnancy and breastfeeding

The use of this medicine is not recommended in pregnant women or during breastfeeding, unless absolutely necessary.

All risks and benefits should be discussed with the doctor before using this medication.

The doctor may prescribe a safer alternative for the patient based on her condition.

Heart disease patients

This medicine should be used with caution in patients with heart disease due to the increased risk of adverse effects on the heart, especially after extensive use.

Appropriate dose adjustments or replacement with an appropriate alternative may be required depending on the clinical picture.

Patients with hypertension

This medication should be used with caution in patients with a known history of hypertension due to the increased risk of worsening the patient’s condition.

Close monitoring of blood pressure is recommended for such patients.

Patients with gastrointestinal bleeding

This drug can cause severe gastrointestinal bleeding and perforation after long-term use. These adverse events can occur with or without warning symptoms.

This risk is especially higher in the elderly population and in patients with a history of gastrointestinal diseases.

Appropriate dose adjustments or replacement with an appropriate alternative may be required depending on the clinical picture.

Fertile female patients

The use of this medicine can affect female fertility. The patient should discuss all the risks and benefits with his doctor before using this medicine.

Pediatric population

The use of this medicine in children is not recommended as the safety and efficacy of use are not clinically established.

Older adults

This medicine should be used with caution in the elderly population due to the increased risk of serious adverse effects.

These patients should start at lower doses to verify tolerance.

Close monitoring of liver and kidney function may be required for such patients depending on the clinical picture.

Other details

  • It can be taken with or without food, as recommended by the doctor.
  • It is recommended to follow the doctor’s instructions.
  • May cause drowsiness.