Index
Also called fluoromethyl, it is a halogenated ether used for the induction and maintenance of general anesthesia.
Chemical formula
- C4H3F7O.
Presentation
Volatile liquid: Sevoflurane (Piramal) inhalation solution of 1 mL / mL, 250 mL.
Indications
Sevoflurane belongs to the group of medicines known as general anesthesia.
It is used to cause general anesthesia (loss of consciousness) before and during surgery in an inhaled form.
Although Sevoflurane can be used alone, it is often used in combinations of anesthetics. This helps produce more effective anesthesia in some patients.
General anesthetics are administered only under the immediate supervision of an anesthesiologist.
If a patient receives general anesthesia during surgery, the anesthetist will administer the medication and monitor its progress.
Mechanism of action
The mechanism of action of Sevoflurane is to interrupt standard synaptic transmission, alter the reuptake of neurotransmitters, and alter postsynaptic receptors or ion flow.
Dose
The amount of medication administered will depend on its potency of this.
In addition, the amount of dose, the time between doses, and the total time to administer the medication depend on the use that is being given to the drug.
They also depend on:
- Age.
- The general physical condition.
- The type of surgery that is performed.
- Other medications you are taking or will receive before and during surgery.
Side effects
Along with the desired effects, a medication can cause some side effects.
The anesthesiologist will closely monitor its effects while the patient is receiving and recovering from an inhalation anesthetic such as Sevoflurane.
However, some effects may not be evident at the time.
Some side effects usually do not require medical attention.
These side effects may go away during treatment as your body adjusts to the medication.
In addition, the anesthesiologist can inform on ways to prevent or reduce some of these side effects:
- Sickness.
- Vomiting
- Agitation.
- Drowsiness.
- Dizziness
- Increased salivation.
- Tachycardia.
- Bradycardia.
- Hypotension.
- Increase in cough
- Laryngospasm.
- Obstruction of the respiratory tract.
- Restraint of breathing
- I am shaking chills.
- Apnea.
- Hypertension .
- Malignant hyperthermia .
- Hiperpotasemia perioperatoria.
- Renal injury as glucosuria and proteinuria .
- Convulsions, especially in children.
- Postoperative hepatic dysfunction.
- Polymorphic ventricular tachycardia.
- Transient glucose elevations.
- White blood cell count.
Warnings and contraindications
Specialists can only administer Sevoflurane with experience in general anesthesia.
Must be available at administration, intubation, artificial ventilation, oxygen, and circulatory resuscitation.
This medication is not recommended in patients suffering from renal insufficiency, severe hepatic insufficiency, cases of susceptibility to malignant hyperthermia, or sensitivity to halogenated agents.
The doctor should be informed if there has ever been any reaction due to allergy or unusual with administering this medicine or other medicines, some foods, dyes, preservatives, or any other type.
Sevoflurane has been tested in children. It can cause agitation (excitement) in children when used to start anesthesia while still awake.
Children who receive Sevoflurane during surgery may also be agitated when they wake up after surgery.
Sevoflurane has been tried and does not cause different side effects in older people than in younger adults.
However, older people generally need smaller amounts than younger people.
Studies in animals have shown an adverse effect, but studies in pregnant women have not demonstrated a risk to the fetus.
However, they should be used only under strict medical administration.
There are no adequate studies on women to determine the risk of children using this medicine during breastfeeding.
Despite the possible benefits against the potential risks before taking this medicine, breastfeeding should be suspended.
Blood pressure, liver and kidney function, and urine flow should be monitored during treatment.
Precautions while using this medication
For those patients who return home within 24 hours after receiving this medication:
- Sevoflurane can cause some people to feel sleepy, tired, or weak after receiving it. It can also cause problems with coordination and the ability to think. Therefore, for approximately 24 hours (or more if necessary) after receiving Sevoflurane, vehicles should not be driven, machinery operated in motion, or anything that may require a state of alert.
- Unless otherwise directed by the physician, alcoholic beverages or other central nervous system depressants should not be taken for approximately 24 hours after receiving Sevoflurane. Taking these medications or drinking alcoholic beverages may increase the effects of Sevoflurane.
Interactions
The use of this medication with the following medicines may cause interactions:
- Amifampridina.
- Amisulpride.
- Bepridil.
- Cisapride.
- Dronedarone.
- Mesoridazina.
- Pimozide.
- Piperaquine.
- Saquinavir.
- Sparfloxacin.
- Terfenadine.
- Thioridazine.
- Ziprasidone.
