Petidine: Uses, Administration, Side Effects, Precautions and Interactions

It is an analgesic that is used to relieve moderate to intense pain.

Including the pain associated with labor and pain before, during and after an operation.

In general, this medication is used to relieve pain in a variety of situations.


Your doctor or nurse will give you the correct dose by injection. If necessary, this dose can be repeated.

Remember to use it at the same time every day, unless your doctor specifically tells you not to use it.

Certain medical conditions may require different dosing instructions as directed by your doctor.

What dose?

The dosage will depend on your age, sex, medical condition, response to therapy and use of certain medications that interact.

Pethidine may impair the mental and / or physical abilities required to drive or operate machinery; Patients with this medication should not drive or operate machinery.

Side effects

  • Daze.
  • Dizziness.
  • Drowsiness.
  • Nausea.
  • Vomiting
  • Perspiration.
  • Constipation .
  • Dry mouth.
  • Feeling restless or agitated

If any of these persist or consider them serious, inform your doctor or pharmacist. Tell your doctor immediately if you develop any of the following symptoms:

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

It is unlikely that a serious allergic reaction to this drug will occur, but seek immediate medical attention if it occurs.

Symptoms of a severe allergic reaction include:

  • Acne.
  • Itching and swelling (especially of the face, tongue or throat).
  • Dizziness
  • Difficulty breathing.

This is not a complete list of possible side effects. If you notice other effects not mentioned above, contact your doctor or pharmacist.

The yellow card scheme allows you to report suspicious side effects of any type of medication (including vaccines, herbs, and over-the-counter medications) that you are taking.

Precautions of Petidine

Before taking pethidine, tell your doctor or pharmacist if you are allergic to it; or to other opioid analgesics; or if you have any other allergies. This medication should not be used if you have certain medical conditions.

Before using this medication, consult your doctor or pharmacist in case of:

  • History of pethidine allergies.
  • High intracranial pressure (increased pressure on the brain).
  • Head injuries
  • A tumor in your adrenal gland called a pheochromocytoma .
  • Respiratory depression or obstructive airway disease.
  • Patients receiving monoamine oxidase inhibitors or within two weeks after their extraction.

Before using this medication, tell your doctor or pharmacist your medical history, especially any of the following:

  • Respiratory difficulties
  • Newborn babies.
  • Premature babies.
  • Elderly patients
  • Debilitated patients
  • Severe liver disease.
  • Severe kidney disease.
  • Disorders of the biliary tract.
  • Thyroid gland not active.
  • Adrenal cortical insufficiency (a condition in which the adrenal glands, located on the kidneys, do not produce adequate amounts of steroid hormones).
  • Shock Enlarged prostate gland.
  • Rapid or erratic heartbeat.
  • Myasthenia gravis (a condition that causes muscle weakness).
  • Acute alcoholism
  • Seizure disorders (attacks).


An overdose of pethidine may cause seizures (fits), respiratory depression (difficulty breathing), hypotension, shock, and coma.

Specific conditions:

The elderly: Pethidine should be used with caution in the elderly as these patients may be more sensitive to the unwanted effects of pethidine.

Pregnancy and breast-feeding:  Pethidine is not safe to take if you are pregnant or planning to become pregnant.

The use during labor can cause breathing difficulties in the newborn baby.

It is wise to limit the use of medications during pregnancy whenever possible. However, your doctor may decide that the benefits outweigh the risks in individual circumstances and after a careful assessment of your specific health situation.

Pethidine is not safe to take if you are breast-feeding. It is wise to limit the use of medications during breastfeeding whenever possible.


Before using this medication, tell your prescriber about all the medications you are taking, including prescription and over-the-counter medications.

Tell your doctor if you are taking vitamins or complementary remedies, such as herbal products, as these can also interact with medications.

If you are taking more than one medication, they can interact with each other. Your prescriber may decide to use medications that interact with each other if the benefit outweighs the risks. In these cases, it may be necessary to adjust the dose of your medications or control it more closely.

The following medications may interact with pethidine:

  • Inhibitors of monoamine oxidase.
  • Medications for anxiety .
  • Medications for sleep problems.
  • Medications to treat depression , such as citalopram or paroxetine.
  • General anesthetics.
  • Carbamazepine and phenytoin, which are used to treat epilepsy.
  • Cimetidine, is used to treat stomach ulcers This information does not contain all possible interactions.

Therefore, inform prescribers of all the products you are using before taking this medication. If you have any questions or want to discuss your medication, talk to your local pharmacist.

Does alcohol consumption affect this medication?

You should not drink alcohol while using pethidine.


  • Do not store above 25 ° C.