Carbamazepine: Description, Uses, Adverse Reactions, Precautions, Presentation and Dosing

It is a prescription medication used to treat epilepsy and trigeminal neuralgia (a condition that causes pain in the facial nerve).

Treats bipolar disorder and seizure disorders. It can interact with many medications. Tell your doctor about all the medicines you take.

Description of Carbamazepine

  • It belongs to a group of drugs called anticonvulsants, which work by decreasing abnormal electrical activities in the brain that cause seizures.
  • It also works by blocking nerve signals that cause pain in trigeminal neuralgia.
  • It comes in the form of an immediate-release tablet, a prolonged-release tablet, extended-release capsules, a chewable immediate-release tablet, and an oral suspension.
  • It can be taken 2 to 4 times a day, with or without food.
  • Common side effects of Carbamazepine include dizziness, drowsiness, nausea, and vomiting.
  • Do not drive or operate heavy machinery until you know how Carbamazepine will affect you.

The genetic information of Carbamazepine

Severe adverse reactions to Carbamazepine include life-threatening skin disorders such as Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (NET).

Some patients with a specific genetic mutation are more likely to experience these reactions. This genetic mutation is found almost exclusively in patients of Asian descent.

Applications

Carbamazepine is a prescription drug used to treat certain types of seizures (partial, tonic-clonic, mixed) and nerve pain ( neuralgia trigeminal and glossopharyngeal).

This medicine may be prescribed for other uses. Consult your doctor or pharmacist for more information.

Adverse Information

The most common side effects of Carbamazepine include:

 

  • Dizziness
  • Drowsiness.
  • Problems with walking and coordination (instability).
  • Nausea.
  • Vomiting

Precautions

Carbamazepine can cause serious side effects, which include:

Rare but severe skin rashes that can cause death:

These severe skin reactions are more likely to occur when you start taking Carbamazepine within the first four months of treatment but may arise later.

These reactions can occur in anyone, but it is more likely in people of Asian descent. If you are of Asian descent, you may need a genetic blood test before taking Carbamazepine to see if you have a higher risk of severe skin reactions with this medicine.

Symptoms may include:

  • Acne.
  • Urticaria.
  • Sores in the mouth.
  • Blisters
  • Skin peeling

Rare but severe blood problems:

Symptoms may include:

  • Fever.
  • Sore throat.
  • Other infections appear and disappear.
  • Easy bruises
  • Red or purple spots on the body.
  • Bleeding gums.
  • Nasal hemorrhages.
  • Severe fatigue or weakness

Like other antiepileptic drugs, Carbamazepine can cause suicidal thoughts or actions in a minimal number of people, approximately 1 in 500.

Call your health care provider right away if you have any of these symptoms, especially if they are new, get worse, or are worried:

  • Thoughts about suicide or death.
  • Attempted suicide.
  • New or worse depression
  • New or worse anxiety
  • Agitation or restlessness
  • Panic attacks.
  • Problems sleeping ( insomnia ).
  • New or worse, irritability.
  • Aggressive performance
  • Anger.
  • Violence.
  • Act on dangerous impulses.
  • Extreme increase in activity and talking (mania).
  • Other unusual changes in behavior or mood.

Carbamazepine may cause other serious side effects:

These include:

  • Irregular heartbeat.
  • Fast, slow, or strong heartbeat.
  • Difficulty breathing.
  • Sensation of dizziness.
  • Fainting.
  • Liver problems
  • Yellowing of the skin or the whites of the eyes.
  • Dark urine.
  • Pain in the right side of your stomach area (abdominal pain).
  • Easy bruising
  • Loss of appetite
  • Nausea or vomiting

Do not take Carbamazepine if:

  • Have a history of bone marrow depression.
  • Allergic to Carbamazepine or any of its ingredients.
  • Tomar nefazodone.
  • Allergic to medications called tricyclic antidepressants (TCA). If you are not sure, ask your health care provider or pharmacist for a list of these medications.
  • You have taken a monoamine oxidase inhibitor (MAOI) medicine in the last 14 days. If you are not sure, ask your health care provider or pharmacist for a list of these medications.

Do not drink alcohol or take other drugs that make you sleepy or dizzy while taking Carbamazepine until you talk to your healthcare provider.

Carbamazepine taken with alcohol or drugs that cause drowsiness or dizziness may worsen your drowsiness.

It can slow down your motor and thinking ability. Food interface with Carbamazepine

Grapefruit juice and grapefruit juice can interact with Carbamazepine and cause potentially dangerous effects. Talk to your doctor about the use of grapefruit products.

Carbamazepine can make your contraception less effective. Tell your health care provider if your menstrual bleeding changes while taking contraception and Carbamazepine.

If you are pregnant or breastfeeding.

Tell your healthcare provider about all the medications you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

Carbamazepine and pregnancy Tell your doctor if you are pregnant or plan to become pregnant.

It has been shown that drugs of category D present a risk to the fetus in studies of pregnant women but can be administered to pregnant women; the benefits for women outweigh the possible risks to the fetus.

Carbamazepine and lactation

This medicine is excreted in human breast milk. You and your doctor should discuss whether you should take Carbamazepine or breastfeed; You should not do both.

Presentation and recommendations

It comes in the form of an immediate-release tablet, a prolonged-release tablet, extended-release capsules, an immediate-release chewable tablet, and an oral suspension.

Carbamazepine can be taken 2 to 4 times a day, with or without food.

Take Carbamazepine precisely as prescribed. Your healthcare provider will tell you how much Carbamazepine you should take.

Do not stop taking Carbamazepine without first talking to your healthcare provider. Stopping Carbamazepine can suddenly cause serious problems.

The sudden suspension of anticonvulsant medications in a patient with epilepsy can cause seizures that will not go away (status epilepticus).

Your healthcare provider can change your dose. Do not change your amount of Carbamazepine without talking to your healthcare provider.

Take Carbamazepine with food.

Pills and extended-release capsules:

  • Do not crush, chew or break.
  • Tell your health care provider if you can not swallow the extended-release tablets.

Carbamazepine suspension:

  • Shake the bottle well before using it.
  • Do not take Carbamazepine suspension at the same time you take other liquid medications.

If you take too much Carbamazepine, call your health care provider or the local Poison Control Center immediately.

Dosage of Carbamazepine

Take this medication exactly as prescribed by your doctor. Follow the instructions carefully on the label of your recipe.

The dose recommended by your doctor may be based on the following:

  • The condition that is being treated.
  • Other medical conditions you have.
  • Other medications you are taking.
  • How you respond to this medication
  • Your weight (children).
  • Your age.

The recommended dose range of Carbamazepine is 400-1200 mg / day.

The recommended initial dose range of Carbamazepine in children under six is 10 to 20 mg/kg/day and can be increased to a maximum of 35 mg/kg.

The number of times you take Carbamazepine will depend on your formulation.

Overdose

If you take too much of this medication, call your health care provider or the local Poison Center, or seek emergency medical attention immediately.

If a health care provider administers this medication in a medical setting, an overdose is unlikely to occur.

However, if an overdose is suspected, seek emergency medical attention.

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  • Do not store prolonged-release tablets more significantly than 30 ° C (86 ° F).
  • Keep the tablets dry.
  • Do not store chewable tablets above 30 ° C (86 ° F).
  • Keep chewable tablets out of the light.
  • Keep chewable tablets dry.
  • Store the capsules between 15 ° C and 30 ° C (59 ° F to 86 ° F).
  • Keep the pills dry.
  • Do not store Carbamazepine suspension above 30 ° C (86 ° F).
  • Shake the suspension well before use.
  • Keep the Carbamazepine suspension in an airtight, light-resistant container.
  • Keep the medication and all medications out of the reach of children.