Pepsamar: Uses, Mechanism of Action, Side Effects, Precautions, Administration and Interactions

It is a medicine indicated for the symptomatic relief of gastric disorders.

Frequent heartburn or gastroesophageal reflux disease (GERD), which occurs more than twice a week, generally responds better to heartburn medications taken daily rather than those born when you feel sick. Heartburn.

Most over-the-counter treatments are not meant to be taken daily for a long time. Check with your doctor to see if you need prescription medicine for heartburn.

Pepsamar is used for heartburn, peptic ulcer pain, sour stomach, and other conditions. Pepsamar may also be used for purposes not mentioned in this medication guide.

Pepsamar contains aluminum hydroxide as an active ingredient. It works by neutralizing the acids released in the stomach.

Sanofi-Aventis Farmacêutica manufactures Pepsamar. The aluminum hydroxide is available without a prescription.

Aluminum hydroxide is an inorganic salt used as an antacid. It is an essential compound that acts by neutralizing hydrochloric acid in gastric secretions.


Subsequent increases in pH can inhibit the action of pepsin. An increase in bicarbonate ions and prostaglandins can also confer cytoprotective effects.

Pepsamar is used to lower phosphate levels in certain kidney conditions. It binds to phosphate in the intestine, which is less absorbed into the body. Controlling phosphate levels helps prevent bone problems (renal osteodystrophy).

It can be used alone or with other medications that reduce acid production (for example, H2 blockers such as cimetidine/ranitidine and proton pump inhibitors such as omeprazole ).

This compound belongs to the inorganic compounds known as post-transition metal hydroxides.

These are inorganic compounds in which the largest oxoanion is the hydroxide and in which the heaviest atom that is not in an oxoanion is a post-transition metal.


  • Post-transition metal hydroxide / Inorganic post-transition metal salt / Inorganic hydride / Inorganic oxide / Inorganic salt.


The gastric-peptic disease occurs due to an imbalance between protective factors, such as mucus, bicarbonate, and prostaglandin secretion, and aggressive factors, such as hydrochloric acid, pepsin, and Helicobacter pylori (H. pylori).

Pepsamar works by restoring the acid-base balance, attenuating pepsin activity, and increasing the secretion of bicarbonate and prostaglandin.

In prescription form (usually higher doses than over-the-counter versions), Pepsamar can generally relieve heartburn and treat reflux, especially if you’ve never received treatment before.

This medicine is beneficial in relieving heartburn, but it may not be as good at treating esophagitis (inflammation that occurs in the esophagus) resulting from gastroesophageal reflux disease.

Uses of Pepsamar

Pepsamar is used to treat symptoms of increased stomach acid, such as heartburn, upset stomach, sour stomach, or acid indigestion. Pepsamar is also used to lower phosphate levels in people with certain kidney conditions.

Pepsamar is an inorganic salt used as an antacid. It is an essential compound that acts by neutralizing hydrochloric acid in gastric secretions. Subsequent increases in pH can inhibit the action of pepsin.

An increase in bicarbonate ions and prostaglandins can also confer cytoprotective effects.

Pepsamar is used for the treatment, control, prevention, and improvement of the following diseases, conditions, and symptoms:

Pepsamar can also be used for purposes not listed here. This section contains uses of this drug that are not listed on the approved drug label but may be prescribed by your healthcare professional.

Use this medication for a condition listed in this section only if it has been prescribed for you by your healthcare professional. Aluminum hydroxide is also used to lower phosphate levels in certain kidney conditions (usually in capsule form).

Mechanism of action

Aluminum hydroxide is an essential inorganic salt that works by neutralizing hydrochloric acid in gastric secretions. Aluminum hydroxide slowly solubilizes in the stomach and reacts with hydrochloric acid to form aluminum chloride and water.

It also inhibits the action of pepsin by increasing the pH and through adsorption. Cytoprotective effects can occur through increases in bicarbonate ions (HCO3-) and prostaglandins.

Aluminum hydroxide

Aluminum is a natural mineral, amphoteric; it has both basic and acidic properties.

Closely related are aluminum oxide hydroxide, AlO (OH), and aluminum oxide or alumina (Al2O3), the latter of which is also amphoteric.

These compounds together are the main components of aluminum ore bauxite.

Both gibbsite and hydrargillite refer to the same polymorphism of aluminum hydroxide, and gibbsite is more commonly used in the United States. Hydrargillite is used more often in Europe.

Brands include Alu-Cap, Aludrox, Gaviscon, and Pepsamar. It reacts with excess acid in the stomach, reducing the acidity of the stomach contents, which can alleviate the symptoms of ulcers, heartburn, or dyspepsia.

Such products can cause constipation because aluminum ions inhibit smooth muscle cell contractions in the gastrointestinal tract, decreasing peristalsis and lengthening the time required for stool to pass through the colon.

Aluminum hydroxide is sometimes mistakenly called “alum,” which appropriately refers to aluminum potassium sulfate.

Aluminum hydroxide is an antacid available in over-the-counter (OTC) medications that relieve heartburn, acid indigestion, sour stomach, and upset stomach.

Aluminum hydroxide can be found in heartburn medications that contain more than one active antacid ingredient. It can also be found in drugs that treat other symptoms, such as gas.

Aluminum hydroxide is approved by the US Food and Drug Administration (FDA) and is safe and effective when used according to the Drug Facts label.

Antacids that contain aluminum hydroxide can interact with certain prescription medications. If you are taking a prescription drug, do not take an over-the-counter drug that contains aluminum hydroxide without consulting a healthcare provider.

Possible side effects with Pepsamar

Some of the side effects can be rare but serious. See your doctor if you notice any of the following side effects, especially if they don’t go away:

  • Constipation.
  • Loss of appetite
  • Confusion.
  • Unusual tiredness
  • Muscular weakness.

Tell your doctor if these symptoms are severe or do not go away. Pepsamar can also cause side effects not mentioned here. Stop using the medicine and call your doctor right away if you have severe side effects such as:

  • Bloody, black, or tarry stools.
  • Coughing up blood that looks like coffee grounds.
  • Pain when urinating

Less serious side effects are more likely, and you may not have any. This is not a complete list of side effects, and others may occur.

If you notice other side effects not listed above, contact your doctor for medical advice. You can also report side effects to your local food and drug management authority.

Can pepsamar cause problems?

The unwanted effects often improve as your body adjusts to the new drug, but talk to your doctor or pharmacist if any of the following symptoms continue or become troublesome.

If you experience any other symptoms that you think may be due to the capsules, speak to your doctor or pharmacist for further advice.

Pepsamar precautions

Pepsamar alone or other medications treat heartburn, upset stomach, peptic ulcer and related pain, and gastroesophageal reflux disease (GERD).

It is also used in patients with kidney problems to reduce phosphate levels. Some health conditions can make you more susceptible to drug side effects.

Consult a doctor or pharmacist before taking this medicine if you have kidney disease, kidney stones, severe constipation, dehydration, or if you drink alcohol frequently.

To make sure this is the proper treatment for you, before taking Pepsamar capsules, your doctor or pharmacist must know the essential points of advice listed below:

  • Breast-feeding.
  • Do not use aluminum hydroxide for more than two weeks unless your doctor tells you to.
  • Frequent use of alcohol
  • Gastrointestinal bleeding.
  • Heart disease.
  • Hypertension.
  • Kidney disease
  • The pregnancy.

Pepsamar can pass into breast milk and may harm a nursing baby. Do not use this medicine without telling your doctor if you are breastfeeding a baby. Tell your doctor immediately if you experience confusion, unusual tiredness, or muscle weakness.

Pepsamar Administration

Before taking the capsules, read the manufacturer’s printed information leaflet from inside the pack. It will provide you with more information about Pepsamar and will provide you with a comprehensive list of the side effects you may experience from taking it.

To ensure you get the correct dose, measure the liquid with a marked measuring spoon or medicine cup, not a regular tablespoon. Ask your pharmacist for one if you don’t have a dose-measuring device.

For indigestion in adults, take one capsule four times a day with meals and once at bedtime. The capsules are not suitable for children to take as antacids. Antacids are best taken when symptoms are likely to occur.

Because antacids are usually taken as needed, you may not be on a dosing schedule. If you take medicine regularly, take the missed dose as soon as you remember.

Do not take the capsules simultaneously as other medications; allow two hours between taking aluminum hydroxide capsules and any other medicine.

If you are taking Pepsamar for aluminum hydroxide to reduce the amount of phosphate in your body, your doctor will tell you how many capsules to take each day. You may be asked to take between 4 and 20 pills a day. Take the capsules spaced throughout the day with your meals.

It is essential to keep all medications out of the reach and sight of children, as many containers (such as weekly pill keepers and eye drops, creams, patches, and inhalers) are not resistant to children, and small children can easily open them.

Ask your pharmacist if you have any questions about refilling your prescription.

You must keep a written list of all prescription and over-the-counter (over-the-counter) medications you are taking and any products such as vitamins, minerals, or other dietary supplements.

It is also vital information to take with you in case of emergencies.

Pepsamar can interfere with other medications taken at the same time and can prevent them from forming correctly. It is best to allow two hours between taking aluminum hydroxide and any other medicines.


If you take other medicines or over-the-counter products simultaneously, the effects of Pepsamar may change. Pepsamar may interact with the following medications and products:

  • Ascorbic acid.
  • Bisphosphonate derivatives.
  • Cephalosporins.
  • Stratos.
  • Corticosteroids
  • Cyclosporine .
  • Delavirdine.
  • Imidazole antifungals.
  • Iron salts.
  • Isoniazid.

Hypersensitivity to Pepsamar is a contraindication. Also, Pepsamar should not be used if you are allergic to aluminum hydroxide.

Tell your doctor or pharmacist what prescription and nonprescription medicines you are taking, especially:

  • Alopurinol (Lopurin, Zyloprim), alprazolam (Xanax), clordiazepóxido (Librium, Mitran y otros), cloroquina (Aralen), cimetidina (Tagamet), clonazepam (Klonopin).
  • Clorazepate, dexamethasone (Decadron and others), diazepam (Valium, Valrelease, and Zetran), diflunisal (Dolobid), digoxin (Lanoxin), ethambutol (Myambutol), famotidine (Pepcid), halazepam (Paxipam) Hydrocortone.
  • Isoniazid (Laniazid, Nydrazid), levothyroxine (Levothroid, Levoxyl, Synthroid), lorazepam (Ativan).
  • Methylprednisolone (Medrol), oxazepam (Serax), penicillamine (Cuprimine, Depen), prednisone (Delta), tetracycline (Sumycin, Tetracap, and others), ticlopidine (Ticlid), and vitamins.

Get the most out of your treatment.

If you are taking Pepsamar for indigestion

Some foods can make your symptoms worse. Foods and drinks suspected of this include peppermint, tomatoes, chocolate, spicy foods, hot drinks, coffee, and alcoholic beverages.

If it seems like food is making your symptoms worse, try avoiding it for a while to see if your symptoms improve. Also, try to avoid eating large meals, as these can also worsen your symptoms.

If at any time you develop any of the following symptoms, talk to your doctor as soon as possible: difficulty swallowing, blood loss, weight loss, or if you are sick. These are symptoms sometimes associated with indigestion that your doctor will want to investigate further.

If you have been prescribed Pepsamar for the treatment of kidney disease

Try to keep your regular appointment with your doctor to monitor your progress. Your doctor will likely want you to have blood tests done from time to time.