Pemix: Description, Side Effects, Tolerability, Dosage and Interactions

It is a gastroprokinetic agent and antiulcer agent of the benzamide class that is marketed in India, Mexico, Pakistan, and Spain.

Remix ​​(trade names Cintapro, Cinitapride) is an effective medicine used to increase the mobility of food in the stomach and intestine.

It is used to treat gastroesophageal reflux disease, non-ulcer dyspepsia, gastrointestinal motility disorders, etc. The Remix ​​is ​​used in the treatment and prevention of heartburn, functional dyspepsia, inflammation of the esophagus, and acid secretion from the stomach.

Gastroesophageal reflux disease

This medicine is used to treat gastroesophageal reflux disease, a condition in which the contents of the stomach return to the esophagus and is characterized by symptoms such as heartburn, bad breath, acid taste, etc.

Non-ulcer dyspepsia

This medication treats non-ulcer dyspepsia or functional dyspepsia, a condition characterized by symptoms such as chronic abdominal pain, nausea, abdominal discomfort, feeling full, etc.


This medication is used to treat gastroparesis, a condition in which food movement from the stomach is prolonged, causing a delay in emptying.

Description of Remix

It acts as an agonist of 5-HT1 and 5-HT4 receptors and an antagonist of 5-HT2 receptors.


This medicine works by increasing the concentration of a particular chemical in the nerve endings, which causes an increase in the movement of the stomach muscles. This helps in faster food movement from the stomach to the intestine.

Remix ​​side effects

When using Pemix, you may experience side effects such as diarrhea, vomiting, nausea, drowsiness, dizziness, headache, and jaundice. If your reactions persist or get worse over time, seek help from your healthcare provider as soon as possible.

Before using this medication, you should notify your physician if you are allergic to any ingredient it contains, are allergic to any food or medicine or substance, have gastrointestinal bleeding or movement problems, or are taking prescription and non-prescription medications.

Also, you are pregnant or planning to become pregnant or breastfeeding a baby with herbal products or dietary supplements. While you are under this drug treatment, avoid drinking alcohol.

The following is a list of possible side effects from all the ingredients that make up Remix. This is not an understandable list. These side effects are possible, but they don’t always happen. Some of the side effects can be rare but serious.

  • Loss of appetite, diarrhea, skin inflammations, vomiting, nausea, drowsiness, headache, jaundice, muscle pain, and joint pain. See your doctor if you have gastrointestinal bleeding, obstruction, perforation, or movement disorder.
  • It can cause movement disorders or prolong the heartbeat in elderly patients, and risk of cardiac arrhythmias, be careful if you are allergic to the medicine; if you take other drugs or OTC products at the same time, the effects of Pemix ​​could change.

Remix ​​can also cause side effects not mentioned here.

Remix ​​dosage

Your physician’s dosage of this medication should be determined based on your age, general medical history, and the severity of your current condition. The usual dose for adults is 1 mg, taken by mouth three times a day.

The drug should be taken on an empty stomach at least 15 minutes before meals. This medicine is not recommended in patients under 18 years of age.

Take this medicine according to your doctor’s instructions. This medicine should be taken at least 15 minutes before meals. Do not eat larger or smaller amounts than recommended.

Medicines should not be disposed of in sewage or household waste. Ask your pharmacist how to dispose of medications you no longer need.

Missed dose

Take the missed dose as soon as you remember.

Remix ​​overdose

Seek emergency medical treatment or contact a doctor in case of overdose. If you suspect that you or someone else may have overdosed on Pemix, go to the nearest hospital emergency department.

Taking a single dose of expired Pemix ​​is ​​unlikely to produce an adverse event.

Remix ​​absorption

The absorption of premix (12 mg) after oral administration was rapid, reaching peak levels 2 hours after administration.

After intramuscular administration (4 mg), absorption was even faster, reaching peak levels (50% more than oral levels) 1 hour after dosing.

Pharmacokinetic and tolerability study of premix

The remix ​​is ​​a functional dyspepsia drug, and the purpose of a pharmacological study was to investigate the tolerability of Pemix ​​in healthy Chinese volunteers.

A randomized, open-label, single, and multiple-dose study was conducted on 12 healthy volunteers.

Three different doses of Pemix ​​(1, 2, and 4 tablets) were administered to six groups in the single-dose study, and one tablet (1 mg) of Pemix ​​was administered three times daily in the multiple-dose study.

Blood samples were collected at predetermined time intervals after Pemix ​​dosing and analyzed by LC-MS / MS. Eleven volunteers completed the study.

After the single dose, plasma Cmax and area under the curve increased approximately linearly with dosing; no statistically significant differences were found in pharmacokinetics between the three dose groups.

After multiple doses, there were no significant changes in Tmax and t1 / 2 compared to the single-dose results. After repeated doses, AUC0-t and AUC0-∞ increased, while CLz / F decreased slightly.

And there are no differences between men and women. The pharmacokinetic parameters of this study were consistent with the results of the non-Chinese subject study.

In healthy Chinese subjects, good tolerability was demonstrated in single and multiple-dose studies with a dose range of 1 to 4 mg.


All drugs interact differently from person to person. You should check all possible interactions with your doctor before starting any medication.

Is Remix ​​safe with alcohol?

Alcohol consumption is not recommended during treatment with this medicine due to the increased risk of severe side effects.

It is recommended not to do any activity that requires high mental alertness, such as driving a vehicle or using heavy machinery, if you consume alcohol during treatment with this medicine.

Drinking a large amount of alcohol can increase heartburn and lead to acid reflux in the food pipe, causing heartburn. This would decrease the effect of this medicine and could aggravate your underlying condition.

Is there any Pemix ​​warning in pregnancy?

Unknown. Human and animal studies are not available. This medicine in pregnant women is not recommended unless necessary.

Please consult your doctor and discuss all risks and benefits with your doctor before taking this medication.

Is there a warning from Pemix ​​on breastfeeding?

It is probably unsafe to use while breastfeeding, the use of this drug in breastfeeding women is not recommended unless necessary.

Please consult your doctor for all risks and benefits; they should be discussed with the doctor before taking this medication.

Does Pemix ​​affect liver function?

There is no interaction between liver failure and the consumption of this drug. Then the alteration of the dose is not necessary.

General warnings

Elderly: This medicine should be used with extreme caution in elderly patients due to the increased risk of severe side effects. Appropriate dose adjustments or replacement with a proper alternative may be required based on the clinical picture.

Pediatric use: the use of this medicine in patients under 18 years of age is not recommended as the safety and efficacy of use are not clinically established.

Driving and operating machinery: This drug may cause drowsiness in some patients. It is recommended not to perform any activity that requires high mental alertness, such as driving a vehicle or operating machinery if you experience drowsiness during treatment with this medicine.

Interaction with other medicines

Before taking glimepiride, tell your doctor if you are taking any of the following medications:

  • Atropine, Digoxin, and Scopolamine.
  • Aspirin or another salicylate such as magnesium/choline salicylate (Trilisate), salsalate (Disalcid, others), choline salicylate (Arthropan), magnesium salicylate (Magan), or bismuth subsalicylate (Pepto-Bismol).
  • A nonsteroidal anti-inflammatory drug such as ibuprofen (Motrin, Advil, Nuprin, others), ketoprofen (Orudis, Oruvail), diclofenac (Voltaren, Cataflam), etodolac (Lodine), indomethacin (Indocin), nabumetone (Relafen), oxaprozin (Daypro) and naproxen (Anaprox, Naprosyn, Aleve).
  • Un fármaco basado en sulfa, como sulfametoxazol-trimetoprima (Bactrim, Septra), sulfisoxazol (Gantrisina) o sulfasalazina (Azulfidina).
  • Un inhibidor de la monoaminooxidasa (IMAO) Como isocarboxazid (Marplan), tranylcypromine (Parnate), o phenelzine (Nardil).
  • A beta-blocker such as propranolol (Inderal), atenolol (Tenormin), acebutolol (Sectral), metoprolol (Lopressor), and others.
  • A diuretic (water pill) such as hydrochlorothiazide (HCTZ, Hydrodiuril), chlorothiazide (Diuril), and others.
  • Asteroid medications such as prednisone (Deltasone, Orasone, others), methylprednisolone (Medrol, others), and prednisolone (Prelone, Pediapred, others), and others.
  • A phenothiazine such as chlorpromazine (Thorazine), fluphenazine (Prolixin, Permit), prochlorperazine (Compazine), promethazine (Phenergan), and others; – phenytoin (Dilantin).
  • Isoniazid (Nydrazid); rifampin (Rifadin, Rifamate); or over-the-counter cough, cold, allergy, or weight loss medications.

This is not an exhaustive list of possible drug interactions. In addition to the drugs mentioned above, others may also interact with glimepiride or affect your condition.

You may need a dose adjustment or special monitoring if you take any of the medicines mentioned above. Many other medications can increase or decrease the effects of premix or affect your condition.

You should consult your doctor about all possible drug interactions you are taking. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medications, including herbal products.


The use of this medicine is not recommended in patients with a known allergy to remix or any other inactive ingredient present with this medicine.

Gastrointestinal bleeding

This drug is not recommended in patients with gastrointestinal bleeding as it may worsen the patient’s condition.

Mechanical intestinal obstruction

The use of this medicine is not recommended in patients with a known history of intestinal blockage due to the increased risk of worsening the patient’s condition.

Late dyskinesia

The use of this medicine is not recommended in patients with a known history of tardive dyskinesia caused by neuroleptic drugs, as it may worsen the patient’s condition.

Where to buy premix?

You can buy this tablet in most online stores and pharmacies. Depending on your location, the legality will vary as to how and where you can buy Cintapro, and if you don’t have a prescription, it’s an excellent place to start by looking to shop online.