Naphazoline: Uses, Doses, Precautions, Interactions, Side Effects and Contradictions

It is used in nasal sprays to treat the symptoms of nasal congestion. Also, in drops to feast red eyes, irritation of the eyes, and symptoms of the pink look.

Its uses include clearing redness and relieving scratches on the eye caused by irritants and relieving nasal congestion caused by colds, flu, hay fever, and allergies.


Dose dose for the eyes: Install one or two drops in the conjunctival sac (s) every three or four hours.

Spray on the open nostril three to four times a day for your nose. Do not use this medication for more than three to five days.

However, first, check the correct dosages with your pharmacist or doctor.

What special precautions should you take?


  • If you wear contact lenses, remove them before applying naphazoline.
  • If you are using other eye drops, do not use one immediately after the other.
  • Its use is considered safe during pregnancy or lactation; however, consult your doctor first.

The drops should be used with caution if you suffer from the following conditions:

  • Glaucoma.
  • Inflammation of the iris.
  • Cornea damaged.
  • You are about to undergo eye surgery or surgery under general anesthesia.
  • Eye pain.
  • Blurry vision.
  • Diabetes.
  • High blood pressure ( hypertension ).
  • Heart problems and circulation.
  • Overactive thyroid gland.


  • Long-term use is not recommended. Please do not use it for more than five days, or it may cause a condition called rebound congestion.
  • Avoid spraying your eyes.
  • It is not known to cause any problems during pregnancy or lactation.

Use with caution if you have any of the following health problems:


  • Heart disease/blood vessel
  • Hyperactive thyroid
  • Diabetes.
  • High blood pressure (hypertension).

What drug interactions could you experience?

As a rule, always tell your doctor or pharmacist what prescription and over-the-counter medications, vitamins, nutritional supplements, and herbal products you plan to take to ensure that you do not suffer the effects of adverse drug interactions.

What are the side effects of naphazoline?

Side effects may include:


  • Blurry vision.
  • Stinging.
  • Severe allergic reactions
  • Eye pain.
  • Persistent eye irritation.
  • Dilated pupils.


  • Temporary burning
  • Stinging.
  • Dry nose
  • Runny nose.
  • Sneeze.

This is not a complete list of side effects. You must call your doctor if you notice severe or unusual side effects.

What are the symptoms of overdose?

Call a doctor or ambulance immediately if you notice the following symptoms:

  • Strong heartbeat.
  • Dizziness.
  • Nausea.
  • Headache.
  • Humor changes.
  • Problems with sleep.
  • Tremors
  • Abundant sweating.


Closed-angle glaucoma:

  • Naphazoline: Pheniramine should be used with caution in patients with angle-closure glaucoma.
  • Heart disease, hypertension
  • Naphazoline: Pheniramine should be used with caution in patients with heart disease or hypertension.

Prostatic hypertrophy:

Naphazoline: Pheniramine should be used with caution in patients with prostatic hypertrophy.

The pregnancy:

Pheniramine is in category C of the FDA pregnancy. Limited human data suggest a possible relationship between oral administration of pheniramine in the first trimester and respiratory malformations and ocular defects.

However, no association was found with congenital abnormalities when used during pregnancy. In addition, it is not known if naphazoline can cause harm to the fetus when administered to a pregnant woman.

Limited data have not demonstrated a clinically significant effect on the fetus during first-trimester naphazoline exposure. However, other sympathomimetic drugs have been associated with minor malformations, inguinal hernia, and clubfoot.

According to the manufacturer, it should be administered to a pregnant woman only if necessary.


According to the manufacturer, it is not known if naphazoline is excreted in human milk. Because systemic concentrations of naphazoline are expected to be low after ocular administration, the risk of drug exposure to an infant is likely to be minimal.

There are no data available on the use of pheniramine during lactation. Consider the benefits of breastfeeding, the risk of potential exposure to a child’s medicine, and the risk of an untreated or improperly treated condition.

If a breastfeeding baby experiences an adverse effect related to a medication ingested by the mother, health care providers are advised to report adverse effects to the FDA.

Baby Boys:

In case of accidental ingestion, seek professional assistance or contact a Poison Control Center immediately. Accidental oral ingestion in infants and children can cause a coma and a marked reduction in body temperature.

Contact lenses:

Instruct patients to remove contact lenses before ophthalmic administration of naphazoline; phenylephrine. The inactive preservative, benzalkonium chloride, can be absorbed on the surface of soft contact lenses.