This medicine contains an osmotic laxative that holds water in the intestine and causes diarrhea that cleanses the digestive tract.
Components of moviprep
This medicine contains 100 g of Macrogol (polyethylene glycol), 7.5 g of anhydrous sodium sulfate, 2.691 g of sodium chloride, 1.015 g of potassium chloride, 4.7 g of ascorbic acid, sodium ascorbate and aspartame.
Moviprep is available for sale in 4 bags (2 from Bag A and 2 from Bag B) containing white to yellow powder for reconstitution.
Indications of moviprep
It is used to cleanse the gastrointestinal tract .
It is indicated for cleaning the colon in preparation for performing colonoscopy in adults over 18 years of age.
Mechanism of action of moviprep
It causes the osmotic laxative effect and replenishes electrolytes, induces catharsis through strong electrolytes and osmotic effects.
- Dose 1 in the evening before the colonoscopy, 1 liter orally for 1 h (240 ml every 15 min). Follow with 0.5 liter (480 ml) of clear liquid.
- Dose 2 on the morning of the colonoscopy, at least 3.5 hours before the colonoscopy, administer 1 liter orally, for 1 hour (240 ml every 15 minutes). Follow with 0.5 liters (480 ml) of clear liquids until at least 1 hour before the colonoscopy.
Full dose the night before
- Administer dose 1, at 6 pm the night before the colonoscopy, 1 liter orally for 1 h (240 ml every 15 min).
- Administer dose 2, 1.5 hours later, 1 liter orally for 1 h (240 ml every 15 min).
- It is followed by 1 liter of additional clear liquids overnight before the colonoscopy.
Full dose only in the morning
Both doses are consumed in the morning before the colonoscopy.
- Administer the prepared drink from Dose 1 in solution at 3 to 7 am for 30 minutes, then refill the container and drink an additional 500 ml of clear liquid over the next 30 minutes.
- Administer Dose 2 two hours after the start of Dose 1, drink Prepared Dose 2 for 30 minutes, and drink additional clear liquids for the next 30 minutes.
Each A bag contains polyethylene glycol, sodium sulfate, sodium chloride, and potassium chloride, plus excipients and lemon flavoring.
Each bag B contains ascorbic acid, sodium ascorbate.
Bag A and Bag B dissolve together in water to a volume of 1 liter, forming a lemon-flavored oral solution.
It is recommended to drink more than 1 liter of water, soup, soft drinks, fruit juices among others.
Side effects of moviprep
- Abdominal pain.
- Abdominal distension.
- Anal discomfort.
- Anaphylaxis (some of which were serious, such as shock).
- Itching .
- Swelling of the lips, tongue and face.
- Breathlessness .
- Tightness in the chest and throat.
- Shaking chills.
- Syncope .
Warnings and Contraindications
This product is contraindicated in cases of:
- Hypersensitivity to any component.
- Gastrointestinal obstruction, intestinal perforation, gastric retention, ileus , severe ulcerative colitis and toxic megacolon.
Since the product contains sodium ascorbate and ascorbic acid, use with caution in patients with glucose-6-phosphate dehydrogenase (G-6-PD) deficiency.
If severe vomiting occurs, serum electrolytes should be monitored.
Patients at increased risk of arrhythmias such as patients with a history of long QT, uncontrolled arrhythmias, recent myocardial infarction, unstable angina, congestive heart failure or cardiomyopathy, should be administered with caution.
It should be administered with caution in patients with a history of seizures and in patients at increased risk of seizures, such as patients taking medications that lower the seizure threshold for example:
- Tricyclic antidepressants, patients who are recovering from an addiction to alcohol and drugs.
Patients with impaired gag reflex and patients prone to regurgitation or aspiration should be observed during Moviprep administration.
The safety and efficacy of Moviprep in pediatric patients have not been established.
If the patient is over 60 years of age, moviprep should be used with care as it may cause more side effects.
Inform your doctor if you are pregnant or planning to become pregnant. The benefits and risks of using Moviprep during pregnancy should be consulted.
The doctor should be informed if he is breastfeeding, due to the risks for the baby of the administration of the medicine in the mother.
Osmotic laxatives can cause aphthous ulcerations of the colonic mucosa, and there have been reports of more severe cases of ischemic colitis requiring hospitalization.
Do not use other laxatives or stool softeners in conjunction with moviprep, unless directed by your doctor.
The possibility of mucosal ulcerations resulting from bowel preparation should be considered when interpreting colonoscopy findings in patients with known or suspected inflammatory bowel disease.
Medications that affect kidney function, such as diuretics, angiotensin converting enzyme inhibitors, angiotensin receptor blocker, or non-steroidal anti-inflammatory drugs with moviprep should be used with caution.
Laboratory tests before and after colonoscopy (sodium, potassium, calcium, creatinine, and blood urea nitrogen) should be considered in these patients.
Oral medication administered within 1 hour after the start of moviprep administration can be eliminated via the gastrointestinal tract and cannot be absorbed.