Indapamide: What is it? Dosage, Warnings, Side Effects, Interactions and Overdosage

It is a prescription medicine that is used to treat high blood pressure.

It is also given to people with edema (fluid retention), congestive heart disease, or another medical condition.

Indapamide is a diuretic (water pill) that works by helping the kidneys free the body of excess water and salt.

The Food and Drug Administration approved indapamide in 1983. Several pharmaceutical companies manufacture it as a generic drug (no brand version).

Indapamide warnings

Before taking indapamide, tell your doctor if you have or have ever had any of the following conditions:

  • Diabetes.
  • Gout (a type of arthritis caused by an accumulation of uric acid crystals in the joints).
  • Any heart problem.
  • Kidney disease
  • Liver disease
  • Problems are urinating.
  • Lupus (a chronic inflammatory disease).
  • Thyroid or parathyroid disease.
  • Low levels of sodium or potassium in the blood.
  • Persistent vomiting
  • A neurosurgical procedure is known as sympathectomy.
  • Allergies to any medication

Indapamide can affect your blood sugar levels. If you have diabetes, check your condition carefully while using this medication.

Tell your doctor that you are taking indapamide before undergoing any medical or dental procedure.


Also, tell your doctor if you are currently on a low salt diet.

Your doctor may recommend adopting a specific diet and exercise plan while taking indapamide. Follow these instructions carefully:

  • Try to avoid dehydration while using indapamide. Ask your doctor how much liquid you should consume during the day.
  • This medicine can make your skin more sensitive to sunlight. Avoid unnecessary exposure to the sun and tanning booths, and wear sunscreen and protective clothing while outdoors.
  • Your doctor should perform frequent tests to check your body’s response to indapamide.
  • Keep all appointments with your doctor and laboratory.


Indapamide should only be taken during pregnancy when necessary.

Tell your doctor if you become pregnant while using this medication. You will need to discuss the benefits and risks of taking indapamide during pregnancy.

It is not known if this medication passes into breast milk. Do not breastfeed a baby while using this drug.

Side effects of indapamide

Common side effects

Tell your doctor if any of the following side effects become severe or do not go away:

  • Frequent urination (this symptom should decrease after a few weeks of treatment).
  • Mild dizziness or lightheadedness (especially when standing or sitting).
  • Back pain.
  • Constipation.
  • Mild diarrhea
  • Drowsiness.
  • Headache.
  • Nausea.
  • Runny nose.
  • Nervousness.
  • Problems with sleep.
  • Stomachache.
  • Weakness.
  • Vomiting
  • It decreased sexual capacity.

Serious side effects

Tell your doctor immediately if you experience any of the following serious side effects:

  • Chest pain.
  • Blurry vision.
  • Jaundice.
  • Dark-colored urine.
  • Decreased urination or problems urinating.
  • Stool pale.
  • Dry mouth.
  • Fainting.
  • Rapid or irregular heartbeat.
  • Fatigue.
  • Fever, chills, cough, or sore throat.
  • Increased thirst.
  • Loss of appetite
  • Numbness of the hands or feet
  • Intense dizziness, drowsiness, or lightheadedness.
  • Severe stomach pain.
  • Skin red, swollen, peeled, or blistered.
  • Swelling of the hands, ankles, or feet.
  • Muscle pain, weakness, or cramps.
  • Confusion.
  • Mental or mood changes
  • Convulsions
  • Unusual slowness, tiredness, or weakness
  • Bruising or unusual bleeding
  • Signs of anaphylaxis may include a rash, hives, itching, shortness of breath, tightness in the chest, or swelling of the face, mouth, lips, or tongue.


Tell your doctor about all prescription, non-prescription, illegal, recreational, herbal, nutritional, or dietary medications you are taking, especially:

  • Another medication for high blood pressure.
  • Corticosteroids, such as prednisone.
  • Lanoxin (digoxin).
  • Indocin (indomethacin).
  • Lithobid (lithium).
  • Benemid (probenecid).
  • Vitamins

Indapamide and other interactions

Indapamide can cause drowsiness.

Do not drive or do activities that require you to be alert until you know how this medicine affects you.

Indapamide and alcohol

Alcohol can worsen specific side effects of indapamide.

Avoid drinking alcoholic beverages while using this medication.

Dosing of indapamide

Indapamide comes as a tablet to be taken orally, usually once a day in the morning.

Your dose will depend on your medical condition and response to treatment.

You can take this medicine with or without food.

Initially, indapamide may cause you to urinate more frequently.

You may want to take your dose before 6 pm to avoid disturbing your sleep with the need to urinate.

Follow the instructions carefully on the label of your recipe. Do not take more or less indapamide than recommended.

Continue taking indapamide even if you feel well. Do not stop your treatment without first talking with your doctor.


Symptoms of an indapamide overdose may include:

  • Vomiting
  • Nausea.
  • Weakness.

If you suspect an overdose, immediately contact a poison control center or the emergency room.

Missed dose of indapamide

If you miss a dose of indapamide, take it as soon as you remember.

However, if it is almost time for your next scheduled dose, skip the missed dose and continue your regular medication schedule.

Do not take additional medications to make up for the missed dose.