Dolbutin: Pharmacology, Effects, Precautions, Administration, Adverse Reactions and Storage Conditions

It is an antispasmodic used to treat irritable bowel syndrome. This agent works by helping to slow down and normalize movements within the intestine.

The active substance in Dolbutin is trimebutine .

Irritable bowel syndrome (IBS) is a chronic gastrointestinal disorder characterized by abdominal pain or discomfort and alteration in the consistency and frequency of bowel movements leading to constipation or diarrhea .

It is a functional disorder and it is not an organic disease. Indicated for the symptomatic treatment of irritable bowel syndrome (IBS) and the treatment of postoperative paralytic ileus after abdominal surgery .

Trimebutine is a spasmolytic agent that acts directly on smooth muscle to modulate gastric motility. Trimebutine mediates a local anesthetic action by acting as a weak agonist at opioid receptors.

Pharmacology

Trimebutine maleate is a non-competitive spasmolytic agent. It has a moderate affinity for opiate receptors and has a marked antiserotonin activity, especially at the ‘mu’ receptors.

It induces regulation of spontaneous activity and increases the synchronization between electrophysiological peaks and contractions in isolated guinea pig strips from colon and ileum. However, it does not alter normal motility, but regulates abnormal intestinal activity.

Effects of this medicine

This drug controls gastrointestinal motility by acting directly on the gastrointestinal smooth muscle. It acts as a suppressant of hypermotility and a promoter of hypomotility of the gastrointestinal tract.

It is usually used to treat gastrointestinal symptoms (enlarged abdominal sensation, abdominal pain, nausea, and belching) caused by chronic gastritis and irritable bowel syndrome.

Before using this medicine, be sure to tell your doctor and pharmacist if you have already experienced an allergic reaction (itching, rash, etc.) to any medicine.

Precautions

Dolbutin should be used with caution in the elderly, in pregnancy and in lactation.

It is not known if trimebutine passes into breast milk. This medicine should be used during breastfeeding only if the potential benefits outweigh the risks to infants.

Use during pregnancy

Although teratological studies have not shown any drug-related adverse effects on the course and outcome of pregnancy, the use of Dolbutin in pregnant women is not recommended.

Management

The dosage is at the discretion of the practitioner and according to the patient’s condition.

  • For gastrointestinal symptoms caused by chronic gastritis: In general, for adults, take 1 tablet (100 mg of the active ingredient) at a time, three times a day. The dose can be adjusted according to your age and symptom.
  • For irritable bowel syndrome: In general, for adults, take 1 to 2 tablets (100 to 200 mg of the active ingredient) at a time, three times a day.

In any case, strictly follow the instructions.

If you miss a dose, take the dose as soon as possible. If it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. You should never take two doses at the same time.

If you accidentally take more than the prescribed dose, check with your doctor or pharmacist. Stop treatment only on medical order.

Possible adverse reactions to this medicine

The most commonly reported adverse reactions include diarrhea, constipation, thirst, rash, hives, and itching. If any of these symptoms appear, consult your doctor or pharmacist.

The symptoms described below are rarely considered initial symptoms of the adverse reactions indicated in brackets. If you observe or present any of these symptoms consult a doctor immediately.

Some reactions can be:

  • General discomfort.
  • Loss of appetite
  • Yellowing of the skin and whites of the eyes (liver dysfunction, jaundice ).

The above symptoms do not describe all adverse reactions to this drug. Check with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.

Effects of overdose

To date, no cases of overdose have been reported. However, if an overdose occurs after oral administration, gastric lavage is recommended. Treatment should be done according to the symptoms observed.

Storage conditions and other information

  • Keep out of the reach of children.
  • Store away from direct sunlight, heat, and moisture.
  • Discard the rest. Don’t save them.