It is a narcotic drug widely used for motility disorders.
These disorders are those that affect the entire process of movement of food, from entering the mouth until it leaves the body.
Trade names : Debridat, Libertrim, Prescol, Tempolib.
Generic name : trimebutine.
Some of its main uses are:
- Reflux of stomach acids into the esophagus and throat.
- Abdominal pain.
- Disorders in the digestive system, including stomach pain, belching, poor digestion, heartburn, flatulence and others.
- Irritable bowel and other colon disorders that can include diarrhea.
- Digestive tract emptying prior to endoscopies or X-rays.
- Intestinal paralysis after an operation.
- Threw up.
- Achalasia, which consists of the difficulty in swallowing food due to lack of relaxation of the smooth muscle of the digestive tract.
Like the vast majority of medications, it is essential to follow medical instructions and continue treatment at the indicated doses and periods, generally between 20 and 30 days, to obtain the benefits and avoid risks of overdose and others.
Presentations and method of administration of trimebutine
- 100 mg / 200 mg / 300 mg tablets in boxes with 12, 20, 24, 30, 40, 48, 50, 60, 90 and 100 pieces and trademarks such as Krisxon, Libertrim, Debridat and Prescol.
- Oral solution of 20 mg of Trimebutine / 1 ml, in bottle with 30, 40, 100 or 200 ml. The pediatric solution can come as a preparation or in suspension. Made by GSK México, Carnot Laboratorios and others, under the Libertrim and Debridat trademarks.
- Injectable solution with 50 mg / 5 ml, in a concentration of 10 mg as Trimebutine in maleate, in a box with 6 vials.
Consult your doctor to receive the correct use and dosage.
The dose for very elderly adults should be 10 ml of oral solution 3 times a day. The injectable solution applies only to the first day of treatment, subsequently it must be continued orally.
The medicine should be taken about 15 minutes before meals. The maximum dose for an adult is 600 mg per day. The IV injection should be given slowly to prevent fainting.
Contraindications and warnings of trimebutine
- Special precautions in people with kidney failure.
- Allergies or Hypersensitivity: Do not use if you are allergic to trimebutine, acetylsalicylic acid, or aspirin.
- Mixed with alcohol: Alcohol is an irritant to the digestive tract and other parts of the digestive system, which can aggravate the symptoms for which this drug is taken.
- Mix with other drugs: no interactions with other drugs have been detected, care should only be taken when using it by intravenous infusion in combination with sodium pentobarbital, bipenicillins and other drugs with which it could form a precipitate that makes it unusable.
Trimebutine in pregnancy and lactation
Trimebutine has not been evaluated by the FDA (Food and Drug Administration). Some manufacturers do not recommend its use during pregnancy for the same reason, especially during the first trimester.
According to medical studies, trimebutine has a low risk of effects in the infant. It also points out that many countries do not consider it suitable for children under 12 years of age, however, in some countries such as Mexico, special medications are available for children, from 3 kg in weight, and adolescents.
In any case, it is not used if the infant is a premature baby or a newborn. The solution for injection is not indicated because it contains benzyl alcohol, which is a substance that can be toxic to infants.
Trimebutine is very well accepted by the body, however there are some adverse symptoms that occur in at most 1 in 1000 people. These are as follows:
- Allergic reactions: redness of the skin, hives , etc.
- Digestive system: stomach pain, constipation, diarrhea, etc.
- Kidneys: increased urine production.
With a frequency of less than 1 case in every 10,000 people, the following symptoms occur:
- Body weakness
- Dry mouth
- Slight deafness
- Blurry vision.
- Urinary retention.
Pay special attention to the symptoms related to an allergic reaction as, although they are rare, they can be serious.