Clinadol Forte: Pharmacology, Side Effects, Contraindications, Mechanism of Action, Interactions and Dosage

It is an anti-inflammatory and antipyretic analgesic from the phenyl alkanoic acid series.

It has been shown to reduce bone resorption in periodontal disease by inhibiting carbonic anhydrase.

Clinadol forte pharmacology

It is a non-steroidal anti-inflammatory drug (NSAID) of the propionic acid class; it is used to relieve pain and inflammation associated with rheumatoid arthritis and osteoarthritis and inhibit intraoperative miosis.

Clinadol forte exhibits anti-inflammatory, analgesic, and antipyretic activities.

Side effects

The side effects of these drugs can cause discomfort and, in rare cases, have more severe side effects, such as gastrointestinal bleeding, which can lead to hospitalization and even fatal outcomes.

Non-steroidal anti-inflammatory drugs are often essential agents in treating arthritis, but they can also be used for less severe conditions.

Doctors can discuss with their patients the risks and likely benefits of treatment with non-steroidal anti-inflammatory drugs.


Some side effects can be:

  • Severe headache
  • High temperature.
  • Neck stiffness.
  • Intolerance of bright light.
  • Blood in the stool.
  • Black tarry stools.
  • It was vomiting anything or other dark particles that looked like coffee grounds.
  • There is unexplained stomach pain or other abnormal stomach symptoms, indigestion, heartburn, feeling sick, and vomiting.
  • Facial or mouth swelling.
  • Unexplained wheezing, shortness of breath, or skin rash.
  • It was increased bruising or bleeding.
  • Throat pain.
  • Mouth ulcers and a tendency to get infections (symptoms of blood disorders that can rarely occur with clinical forte).
  • Severe skin reactions such as blisters on the skin, mouth, eyes, and genitals (symptoms of some extreme skin conditions that can rarely occur with clinadol forte).
  • Yellowing of the eyes and skin. This is a sign that your liver may not be working correctly.

You may also suffer from symptoms such as:

  • Fatigue.
  • Flu-like symptoms.
  • Weak appetite or loss of hunger.
  • Pain in the abdomen (just below the ribs).
  • Tiredness, swelling in the face, abdomen, thighs, or ankles.

The clinical drug forte has sometimes been associated with heart failure. This is when the heart doesn’t work as well as it should.

People may have tiredness and lack of energy, shortness of breath, and swelling of the legs due to fluid build-up.

Other unusual effects can include:

  • Dizziness
  • Tingling of hands and feet
  • Ringing in the ears.
  • Diarrhea.
  • Constipation.
  • Sensitivity of the skin to the sun.
  • General discomfort. in the mood.
  • Depression.
  • Hallucinations
  • Confusion.

Talk to your doctor, pharmacist, or nurse if you have any side effects.

Contraindications of clinadol forte

Flurbiprofen tablets are contraindicated in patients who have been previously contrasted to the product.

Flurbiprofen should not be administered to patients in whom flurbiprofen, aspirin, or other non-steroidal anti-inflammatory drugs induce hives or different allergic-type reactions.

Fatal asthmatic reactions have been reported in patients who received this type of medication.

Clinadol forte indicationClinadol forte tablets are indicated for the acute, long-term treatment of the signs and symptoms of rheumatoid arthritis and osteoarthritis.

Mechanism of action

The anti-inflammatory effect of flurbiprofen may result from reversible inhibition of cyclooxygenase, which causes peripheral inhibition of prostaglandin synthesis.

Clinadol forte also inhibits leukocyte migration to sites of inflammation and prevents the formation of thromboxane A2, an aggregating agent, by platelets.

Interactions with other medications

A non-total list of interactions of this drug is specified below:

  • Alendronate: increased risk of gastric toxicity.
  • Methotrexate: increases the effect and toxicity of methotrexate.
  • Anisindione: increases the anticoagulant effect.
  • Dicumalar: increases the anticoagulant effect.
  • Acenocoumarol: increases the anticoagulant effect. Warfarin NSAIDs increase the anticoagulant effect.

Avoid alcohol while receiving clinadol forte treatment.

Generic name: Flurbiprofen.

Synonyms: FLP; Flurbiprofen sodium.

Drug category

Anti-inflammatory agents; Analgesics; Non-steroidal anti-inflammatory agents (NSAIDs); Carbonic anhydrase inhibitors; Cyclooxygenase Inhibitors.

Drug type: small molecule; Other brand names that contain flurbiprofen: Adhered; Ansaid; Antadys; Apo-Flurbiprofen; Cebutid; Flurbiprofen Axetil; Flurofen.

Absorption: The mean oral bioavailability of flurbiprofen from tablets is 96% relative to an oral solution.

Toxicity (overdose): LD 50 = 10 mg / kg (orally in dogs).

Protein binding: > 99%

Clinadol forte dosage forms: Oral Extended Release Oral Capsule Tablet, Ophthalmic Liquid.

Frequently asked questions about clinical forte.

What are clinical forte tablets, and what are they used for?

Clinadol forte tablets belong to a group of drugs called non-steroidal anti-inflammatory drugs (NSAIDs).

It can be used to relieve pain and inflammation (redness, warmth, and swelling) in conditions such as:

  • Osteoarthritis (a bone disorder, seen mainly in older people, in which the joints become painful and stiff).
  • Rheumatoid disease (inflammation of the joints and sometimes surrounding tissues).
  • Ankylosing spondylitis (swollen joint, inflammation of the bursa), tendonitis (inflammation of the tendons).
  • Tenosynovitis (inflammation of the covering layer of a tendon).
  • Low back pain, sprains, and strains.

Clinadol forte tablets can also treat other painful conditions, such as toothache, pain after operations, period pain, and migraine.

Clinadol forte 50 mg tablets contain 50 mg of flurbiprofen and clinadol forte 100 mg tablets contain 100 mg of flurbiprofen

What should I know before taking clinadol forte?

Do not take this medicine if:

  • You are sensitive (allergic) to any of the ingredients in the tablets.
  • You have a peptic ulcer (ulcer in the stomach or duodenum), ulcerative colitis, Crohn’s disease, bleeding in the stomach, or have had two or more episodes of peptic ulcers or stomach bleeding or perforation in the past.
  • You have asthma or have had an allergic reaction or wheezing after taking flurbiprofen, ibuprofen, aspirin, or other pain.
  • You are in the last trimester (last three months) of pregnancy.
  • Your doctor has stated that you have severe heart failure, liver failure, or kidney failure.

Tell your doctor before taking this medicine if the answer to any of the following questions about whether:

  • Are you pregnant or planning to get pregnant, or are breastfeeding – Clinadol forte can make it harder to get pregnant. You should inform your doctor that you are pregnant and becomes pregnant or if you have trouble getting pregnant.
  • You have systemic lupus erythematosus (SLE, sometimes known as lupus) or a connective tissue disease (autoimmune diseases that affect connective tissue).
  • You have liver or kidney disease or have been told that you have liver or kidney disease.
  • You have heart problems or have been told that time you have heart problems.
  • Any risk is more likely with high doses and long-term treatment.
  • You have been diagnosed with a disease that affects the time it takes for your blood to clot.
  • Your doctor tells you that you have an intolerance to some sugars.

You are taking other medications such as :

  1. Diuretics (known as water tablets, e.g., furosemide, spironolactone).
  2. Cardiac glycosides (angiotensin II inhibitors [e.g., losartan]).
  3. Blood thinners (for example, warfarin ).
  4. Lithium.
  5. Zidovudine (an antiviral drug).
  6. Methotrexate (used to treat certain cancers).
  7. Cyclosporine and tacrolimus (immunosuppressants) are used to dampen your immune response.
  8. Medicines are known as corticosteroids.
  9. Antidepressant medications are selective serotonin reuptake inhibitors (SSRIs) (for example, fluoxetine and paroxetine).
  10. Antibiotics are called quinolones (such as ciprofloxacin).
  11. Aminoglycosides (a type of antibiotic, for example, streptomycin and gentamicin).
  12. Mifepristone.
  13. Other anti-inflammatory pain relievers, including aspirin and the group of drugs known as COX-2 inhibitors, e.g., celecoxib, lumiracoxib.

Pregnancy and breastfeeding

The use of clinadol forte should be avoided during pregnancy or lactation. Clinadol forte should not be used in the last three months of pregnancy. If you are pregnant or breastfeeding, you should inform your doctor before taking the clinical thing.

Driving and using machines

Using clinadol forte can make you feel dizzy or drowsy. If the tablets are affected in this way, do not drive, do not operate.

How should you take clinadol forte?

Always take clinadol forte precisely as your doctor has told you. If you are not sure, check the label on the carton or ask your doctor or pharmacist. Take your clinadol forte tablets with or after food with a glass of water.


The usual daily dose is 150 to 200 mg, distributed throughout the day. Suppose you take 50mg of clinical three or four times a day. If you take clinadol forte 100 mg, this is one or two tablets a day.

Your doctor may increase the dose to 300 mg per day.

How should I store clinadol forte tablets?

  • Your tablets should be in a safe place out of sight and reach of children.
  • They must be kept in their original packaging.
  • Medicines should not be disposed of in sewage or household waste.