It is an over-the-counter drug, whose active compound is loratadine.
Clarityne is an antihistamine widely used for the relief of hay fever and allergy symptoms, such as sneezing, watery eyes and a runny nose, and other seasonal allergies.
It is also used to treat chronic itching of unknown cause. The drug can cause many common and non-serious side effects.
Chemical formula of clarityne
Its presentation is in tablets of 10 Mg of micronized Loratadine.
It also comes in the form of a syrup. Each 5 ml of syrup contains 5 mg of micronized loratadine and in fast disintegrating tablets to take by mouth.
For the relief of symptoms associated with seasonal or perennial allergic rhinitis , and for the treatment of chronic idiopathic urticaria or other histamine-mediated allergic symptoms such as hives, itching.
This medicine is also used to relieve bee stings and food allergies.
This medicine does not prevent allergies, but should be kept on hand in patients who have already had allergic reactions.
Mechanism of action
Clarityne is highly selective for histamine H1 receptors.
Clarityne works by blocking the binding of histamine in the body; Histamine is the chemical that enters the body and produces the symptoms of allergies, in the gastrointestinal tract, uterus, large blood vessels, and bronchial muscle.
This medication is administered orally, with or without food, in doses of 5 to 10 mg every 24 hours or as directed by your doctor.
Dosage is based on the patient’s age, condition, and response to treatment. The dose should not be increased, nor should this medication be taken more often than directed.
Clarityne side effects
Clarityne can cause side effects such as:
- Dry mouth.
- Nose bleed.
- Throat pain.
- Ulcers in the mouth
- Difficulty falling asleep or falling asleep.
- Soft spot.
- Stomach ache.
- Red or itchy eyes.
Some side effects can be serious.
If you experience any of the following symptoms, you should stop taking clarityne and call your doctor immediately:
- Swelling of the eyes, face, lips, tongue, throat, hands, arms, feet, ankles, or lower legs.
- Difficulty breathing or swallowing.
- Anaphylactoid reactions.
- Hepatic necrosis.
Warnings and Contraindications
- Allergies: clarityne is contraindicated in anyone hypersensitive to the drug or to any of the ingredients of the specific drug formulation, or in any patient hypersensitive to desloratadine, due to cross-sensitivity.
- Asthma: Antihistamines should be used with caution in patients with asthma.
- Driving or operating machinery: Clarityne is generally not sedating. However, the drug may cause drowsiness in individual patients, therefore, patients receiving this drug should be advised to exercise caution when performing activities that require coordination and concentration, such as driving or operating machinery until the effects of the drug are known. medicine.
- Liver disease: clarityne is metabolized in the liver, should be used with caution in patients with liver disease, and initial dose adjustments should be made according to the manufacturer’s guidelines.
- Renal impairment: clarityne should be used with caution in people with impaired kidney function . Exposure and peak concentrations and its metabolite are elevated in the presence of significant renal impairment. Initial dose adjustments should be made according to the manufacturer’s guidelines based on the age of the patient.
- Pregnancy: during pregnancy the use of this medication is quite delicate. Self-medication with loratadine is not recommended during pregnancy. Pregnant patients should consult their healthcare professional for a proper diagnosis and treatment recommendations.
- Lactation: clarityne is excreted in human milk. Breastfeeding women are advised to consult a healthcare professional before using loratadine.
- Children, infants, newborn: The safety and efficacy for the use of clarityne in neonates, infants or children under 2 years have not been established.
- Geriatric Patients: Second-generation non-sedating antihistamines, such as clarityne, are generally preferred for the treatment of allergic rhinitis or other conditions in the geriatric patient. Doses should be adjusted if there is kidney failure.
When administered concomitantly with alcohol, loratadine does not tend to potentiate the effects of alcohol, as evidenced by measurements made in studies of psychomotor performance.
It should be administered with caution when done in conjunction with drugs that inhibit hepatic metabolism.
The treatment can cause interactions in laboratory tests with clarityne must be suspended 48 hours before carrying out any type of skin test , because they can prevent or reduce reactions with indicators of dermal reactivity.