Alevian: Medical Uses, Dosage, Side Effects, Contraindications and Interactions

This product is used to relieve additional gas symptoms such as belching, bloating, and a feeling of pressure / discomfort in the stomach / intestines.

Alevian helps to break gas bubbles in the intestine helping in the symptomatic treatment of pain, transit disorders and intestinal discomfort related to functional bowel disorders (irritable bowel syndrome, spastic colon).

Also in the symptomatic treatment of pain related to functional alterations of the biliary tract ( peptic ulcer , biliary dyskinesia).

Medical uses

This product is used to relieve additional gas symptoms such as belching, bloating, and a feeling of pressure / discomfort in the stomach / intestines.

Use Alevian to decrease symptoms of peptic ulcer and gastric hyperacidity. Kremil-S Gastric hypermotility, spastic and irritable colon, flatulent dyspepsia, gastritis, heartburn, duodenitis, esophagitis, hiatal hernia, postoperative abdominal pain, colic in children.

What is simethicone or Alevian duo?

Simethicone (International Nonproprietary Name or INN), also known as Simethicone (USAN), is an antifoam agent used to reduce swelling, discomfort, or pain caused by excess gas.

It is also responsible for relieving pressure and gas in the digestive tract. It can also be used for other conditions as determined by your doctor.

Alevian is an antiflatulent and adsorbent combination. It works by dividing gas bubbles, making gas easier to remove.


The chemical name for simethicone is α- (trimethylsilyl) -ω-methylpoly (oxy [dimethylsilylene]), mixed with silicon dioxide.


Adult : 50 mg of 1 tablet 3 times a day.

  • Total daily dose: 150 mg. The dose can be increased to a maximum of 2 tabs 3 times a day.
  • Maximum total daily dose: 300 mg.

Adult : 100 mg of 1 tablet 2 times a day.

  • Total daily dose: 200 mg. The dose can be increased to a maximum of 1 tab 3 times a day.
  • Maximum total daily dose: 300 mg.

Pediatric population : experience in pediatric patients (<18 years) is limited, 20-40 mg to be administered with food.


Swallow the tablets without chewing or sucking. Take the tablets with a glass of water in the middle of a meal. The tablet should not be swallowed when lying down or just before bedtime. It can be given with an antacid.

If you forget to take Alevian, it is recommended not to take a double dose to make up for it. If you self-medicate with Alevian, the usual maximum amount for adults is 500 milligrams daily.

Take Alevian as needed after meals and before bed, unless your doctor tells you otherwise.

Alevian can interfere with the absorption of many other medications. Talk to your doctor about taking Alevian 2 hours before or after taking any other medicine. If you miss a dose of Alevian and are using it regularly, take it as soon as possible.

Ask your healthcare provider if you have any questions about how to use Alevian.

Alevian side effects

Like all medicines, Alevian can have side effects, although not everyone gets them.

The following adverse events were spontaneously reported during post-marketing use. A precise frequency cannot be estimated from the available (unknown) data.

Gastrointestinal disorders : gastrointestinal disturbances, eg abdominal pain, diarrhea, nausea, vomiting, and dysphagia (difficulty swallowing) have been observed. Esophageal injury can occur when it is not applied as recommended.

Skin and Subcutaneous Tissue Disorders : Cutaneous (skin) effects, eg rash, pruritus (itching), urticaria, and erythema (redness of the skin) have been observed.

Immune system disorders : hypersensitivity reactions may occur.

Stop using Alevian and call your doctor at once if you have any of these serious side effects:

  • Tremors or restless muscle movements in your eyes, tongue, jaw, or neck, mask-like appearance of the face.
  • Very stiff muscles, high fever, sweating, confusion, fast or uneven heartbeat, tremors, feeling like you might pass out, depressed mood, thoughts of suicide or hurting yourself.
  • Hallucinations, anxiety, agitation, feeling nervous, trouble keeping still, swelling, fluid retention, jaundice (yellowing of your skin or eyes), and seizures.

Less serious side effects of Alevian can include:

  • Feeling restless, sleepy, tired or dizzy, headache, trouble sleeping ( insomnia ), breast tenderness or swelling, changes in your menstrual periods, and urinating more than usual.


Hypersensitivity to Alevian or to any of the excipients of Pinaverium Bromide (Alevian Duo).

Society and culture

The name of the international non-proprietary name is “simeticone”, which was added to the recommended list of international common names in 1999.

Alevian is marketed under many brand names and in many combination drugs; it is also marketed as a veterinary drug.


Before taking Alevian, tell your doctor if you regularly use other medicines that make you sleepy (such as cold or allergy medicines, sedatives, narcotic pain relievers, sleeping pills, muscle relaxers, and medicines for seizures, depression or anxiety). .

They can add to the drowsiness caused by Alevian. Tell your doctor about all other medicines you use, especially:

  • Acetaminophen (Tylenol). Cyclosporine (Gengraf, Neoral, Sandimmune). Digoxin (digitalis, Lanoxin). Glycopyrrolate (Robinul). Levodopa (Larodopa, Atamet, Parcopa, Sinemet). Mepenzolate (Cantil).
  • Tetracycline (Brodspec, Panmycin, Robitet, Sumycin, Tetracap and others). Atropine (Donnatal, and others), benztropine (Cogentin), dimenhydrinate (Dramamine), methscopolamine (Pamine), or scopolamine (Transderm-Scop).
  • Bladder or urinary medications such as darifenacin (Enablex), tolterodine (Detrol), or solifenacin (Vesicare). Bronchodilators such as ipratroprium (Atrovent) or tiotropium (Spiriva).
  • Irritable bowel medications such as dicyclomine (Bentyl), hyoscyamine (Anaspaz, Cystospaz, Levsin), or propantheline (Pro-Banthine).
  • Un inhibidor de la monoamina oxidasa tal como isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), o tranylcypromine (Parnate).
  • Medications to treat psychiatric disorders, such as chlorpromazine (Thorazine), clozapine (Clozaril, FazaClo), haloperidol (Haldol), olanzapine (Zyprexa, Symbyax), prochlorperazine (Compazine), risperidone (Risperdal), thiothixen (Navane), and others.
  • Clinical trials have shown no interaction between Alevian and digitalis drugs (heart drugs), oral antidiabetics, insulin, oral anticoagulants, and heparin.

Coadministration of an anticholinergic drug can improve spasmolysis. No interference was observed with laboratory tests to detect drug level.