Afumix: Components, Indications, Mechanisms of Action, Dose, Interactions and Side Effects

It is a broad-spectrum drug that is usually prescribed to fight vaginal infections. Very useful in the presence of bacterial infections, fungi and parasites.

It is indicated in mixed vaginal infections caused by trichomonas, Candida, Gardnerella vaginalis and anaerobic bacteria.

Components

Fluconazol + tinidazol.

Indications

Afumix is ​​indicated in the combat of fungal diseases developed by very specific parasites and certain bacteria.

Used in the fight against vaginal infections such as vaginitis that is caused by fungi, parasites and bacteria. As well as Candidiasis present in the mouth, throat, esophagus, penis and others.

Also to prevent some infections, if chemotherapy and / or radiotherapy is received or you suffer from AIDS and in the case of bacterial meningitis, athlete’s foot, fungus in the groin, in the body, in the hand, in the nails.

Mechanism of action

Afumix contains two active ingredients, Fluconazole and Tinidazole.

Fluconazole prevents the formation of the membranes of fungal cells, inhibiting the synthesis of ergosterol, an essential molecule located in the membrane, causing leakage of cellular content.

Tinidazole, on the other hand, attacks the genetic material of the cells of some parasites, fungi and bacteria.

Presentation

  • Tablets

Dose

The dose in adults is unique to 4 Tablets of 500 mg of Tinidazole and 37.5 mg of Fluconazole.

The treatment can be administered 2 tablets every 12 hours or the 4 tablets together.

Contraindications

This drug is contraindicated in case of suffering from any of these pathologies:

  • Alterations of the heart rhythm ( Arrhythmia ).
  • Cancer.
  • Failure of the kidneys (Chronic renal failure).
  • Liver problems
  • Neurological disorders of organic origin.
  • Alterations in the coagulation of the blood. This medication may alter the results of some laboratory samples. Tell your doctor if you are taking this medicine before any study is done.
  • Related condition with alterations in blood composition (blood dyscrasias).
  • Hypersensitivity to the drug, allergies to other terfenadine compounds, azoles.

Side effects

The side effects that occur as a result of the use of Afumix are few, this is a very well tolerated medicine.

The most frequent symptoms affect less than 1% of patients and include the following:

  • At the level of the digestive system: Abdominal pain, lack of appetite, flatulence, nausea, metallic taste in the mouth, vomiting and diarrhea.
  • At skin level: May have itching or hives.

Among the symptoms that may occur less frequently are:

  • On the skin: Presence of bullous lesions, blisters with a diameter greater than 5 mm, in addition to lesions in the form of a target.
  • In the blood: There may be a decrease in leukocytes and other components in the blood flow.

The appearance of these symptoms indicates that the treatment should be discontinued and go immediately to the doctor.

Adverse reactions

Adverse effects such as:

Anorexia, discomfort when urinating, dizziness, metallic or bitter taste in the mouth, fatigue, abdominal pain, excessive and frequent menstruation, constipation, diarrhea, intestinal gas, nausea, vomiting, skin rash, acidity, pruritus, urticaria and angioneurotic edema, injuries bullous or erythema multiforme.

Warnings and precautions

In patients with a significant increase in liver enzymes, the risk / benefit to administer the treatment will be assessed.

There have been few reports of exfoliative skin reactions, toxic epidermal necrolysis and Stevens-Johnson syndrome.

When administered in patients with AIDS these can develop skin reactions.

Interactions

      1. With medications

Afumix interacts with the following medications: Rifampicin, Amitriptyline, Anticoagulant Drugs, Glibenclamide, Phenytoin, Terfenadine, Cisapride, Tacrolimus, Cyclosporine, Theophylline, Contraceptive Pills, Zidovudine, Rifabutin, Disulfiram and Diuretics.

In diabetic patients there is the possibility of episodes of hypoglycaemia due to interaction with medications.

      2. Pregnancy

The use of fluconazole / tinidazole should be avoided during pregnancy, especially during the first trimester, it can produce cardiac malformations and in the bones of the fetus.

Except for patients with severe or possibly fatal infections, when the benefit obtained exceeds the potential risk to the fetus.

      3. Breastfeeding

Fluconazole in human breast milk occurs in concentrations similar to the concentrations it has in the plasma, so its use is not recommended during lactation.

Although its effects are still unknown. It is recommended to use formula during the period of treatment.

      4. Effects on the ability to drive

Fluconazole can cause dizziness, so you should take the necessary precautions if you are going to drive a car or use complex machinery.