Afumix: Components, Indications, Mechanisms of Action, Dose, Interactions and Side Effects

It is a broad-spectrum drug that is usually prescribed to fight vaginal infections. Very useful in the presence of bacterial infections, fungi, and parasites.

It is indicated in mixed vaginal infections caused by trichomonas, Candida, Gardnerella vaginalis, and anaerobic bacteria.


Fluconazole + tinidazole.


Lumix is ​​indicated in combatting fungal diseases developed by particular parasites and certain bacteria.

They were used in the fight against vaginal infections such as vaginitis, which is caused by fungi, parasites, and bacteria. As well as Candidiasis present in the mouth, throat, esophagus, penis, and others.

Also, to prevent some infections, if chemotherapy and radiotherapy are received, or you have AIDS and in the case of bacterial meningitis, athlete’s foot, fungus in the groin, in the body, in hand, in the nails.

Mechanism of action

Afumix contains two active ingredients, Fluconazole and Tinidazole.


Fluconazole prevents the formation of the membranes of fungal cells, inhibiting the synthesis of ergosterol, an essential molecule located in the membrane, causing leakage of cellular content.

On the other hand, Tinidazole attacks the genetic material of the cells of some parasites, fungi, and bacteria.


  • Tablets


The dose in adults is unique to 4 Tablets of 500 mg of Tinidazole and 37.5 mg of Fluconazole.

The treatment can be administered two tablets every 12 hours or four tablets together.


This drug is contraindicated in case of suffering from any of these pathologies:

  • Alterations of the heart rhythm ( Arrhythmia ).
  • Cancer.
  • Failure of the kidneys (Chronic renal failure).
  • Liver problems
  • Neurological disorders of organic origin.
  • Modifications in the coagulation of the blood. This medication may alter the results of some laboratory samples. Tell your doctor if you are taking this medicine before any study is done.
  • Related condition with alterations in blood composition (blood dyscrasias).
  • Hypersensitivity to the drug, allergies to other terfenadine compounds, azoles.

Side effects

The side effects that occur due to the use of Afumix are few; this is a very well-tolerated medicine.

The most frequent symptoms affect less than 1% of patients and include the following:

  • At the level of the digestive system: Abdominal pain, lack of appetite, flatulence, nausea, metallic taste in the mouth, vomiting, and diarrhea.
  • At skin level: May have itching or hives.

Among the symptoms that may occur less frequently are:

  • On the skin: Presence of bullous lesions, blisters with a diameter greater than 5 mm, and lesions in the form of a target.
  • There may be a decrease in leukocytes and other components in the blood flow.

These symptoms indicate that the treatment should be discontinued and go immediately to the doctor.

Adverse reactions

Adverse effects such as:

Anorexia, discomfort when urinating, dizziness, metallic or bitter taste in the mouth, fatigue, abdominal pain, excessive and frequent menstruation, constipation, diarrhea, intestinal gas, nausea, vomiting, skin rash, acidity, pruritus, urticaria and angioneurotic edema, injuries bullous or erythema multiforme.

Warnings and precautions

In patients with a significant increase in liver enzymes, the risk/benefit of administering the treatment will be assessed.

Few reports have been exfoliative skin reactions, toxic epidermal necrolysis, and Stevens-Johnson syndrome.

When administered in patients with AIDS, these can develop skin reactions.


  1. With medications

Lumix interacts with the following medications: Rifampicin, Amitriptyline, Anticoagulant Drugs, Glibenclamide, Phenytoin, Terfenadine, Cisapride, Tacrolimus, Cyclosporine, Theophylline, Contraceptive Pills, Zidovudine, Rifabutin, Disulfiram, and Diuretics.

In diabetic patients, there is the possibility of episodes of hypoglycemia due to interaction with medications.

  1. Pregnancy

The use of fluconazole/tinidazole should be avoided during pregnancy, especially during the first trimester; it can produce cardiac malformations in the fetus’s bones.

Except for patients with severe or possibly fatal infections, when the benefit obtained exceeds the potential risk to the fetus.

  1. Breastfeeding

Fluconazole in human breast milk occurs in concentrations similar to the concentrations it has in the plasma, so its use is not recommended during lactation.

Although its effects are still unknown, it is recommended to use formula during the period of treatment.

  1. Effects on the ability to drive

Fluconazole can cause dizziness, so you should take the necessary precautions or use complex machinery if you drive a car.