Zaditen: Chemical Formula, Presentations, Indications, Mechanism of Action, Dosage, Side Effects and Interactions

The active ingredient in this drug is ketotifen. It is indicated in the prevention of bronchial asthma when it is associated with allergic symptoms.

It is used to reduce the frequency and severity of attacks, but it does not stop a crisis that has already started.

Ketotifen should not replace other treatments for respiratory problems in asthma such as corticosteroids.

Ketotifen is also indicated in the prevention and treatment of allergic disorders such as hives, dermatitis, allergic rhinitis, and conjunctivitis .

Zaditen chemical formula

  • C19H19NOS.



Each tablet contains 1 mg of ketotifen and non-medicinal ingredients such as calcium hydrogen phosphate, magnesium stearate, and cornstarch.


Each 5 ml of syrup contains 1 mg of ketotifen and non-medicinal ingredients such as alcohol, citric acid, methyl-p-hydroxybenzoate, propyl-p-hydroxybenzoate, sodium phosphate, sorbitol solution, artificial flavor, sucrose and water.

Zaditen indications

Ketotifen is in a class of medications called asthma allergies and prophylactics.

This medication is used in combination with other medications to treat mild allergic asthma in children.

Ketotifen is an anti-allergy medicine that helps reduce asthma symptoms by reducing the body’s response to allergens (substances that cause allergic reactions).

These allergens can often trigger an acute asthma attack.

Mechanism of action

Ketotifen improves the patient’s condition by performing the following function: inhibiting the release of allergy-causing chemicals, histamines in the body by mast cells.


For children 6 months to 3 years of age, the usual recommended dose is based on body weight, 0.05 mg per kilogram of weight twice a day, in the morning and in the evening.

For children over 3 years of age, the usual recommended dose is 1 mg twice a day, in the morning and in the evening.

To reduce side effects, your doctor may suggest that you start with a lower dose and increase to the recommended dose after 5 days.

Side effects of Zaditen

The side effects listed below are not experienced by all people taking this medication.

  • Abdominal pain.
  • Drowsiness.
  • Dry mouth.
  • Headache.
  • Increased appetite
  • Irritability.
  • Nausea.
  • Nervousness.
  • Sleep disorders.
  • Slight dizziness
  • Weight gain.

Although most of the side effects listed below do not occur very often, they could lead to serious problems if medical attention is not sought.

  • Flu-like symptoms such as sudden lack of energy, fever, cough, sore throat.
  • Nosebleeds
  • Swollen eyelids
  • Respiratory infections.
  • Skin rashes and itching.
  • Irritability.
  • Nervousness.
  • Eye irritation.
  • Eye pain.

Use of the medication should be discontinued and immediate medical attention is sought if signs of a severe skin reaction such as blistering, peeling, a rash covering a large area of ​​the body, a rapidly spreading rash, or a rash combined with fever or malaise are observed.

Warnings and Contraindications

This medicine should not be given to anyone who:

  • Are allergic to Zaditen or any ingredient in this medicine.
  • Be sensitive to benzoate compounds.
  • Before starting to use a medication, you should be sure to inform the medical patient of any medical conditions or allergies they may have, any medications they are taking, if they are pregnant or breastfeeding, and any other important information about the patient’s health. These factors can affect the way you should use this medicine.
  • If you have diabetes, it should be noted that the syrup form of this medicine contains 4 g of carbohydrates for every 5 ml of syrup. There have also been reports of a decreased blood cell count in people taking antidiabetic drugs and Zaditen
  • This medicine may make you drowsy. Children may experience drowsiness in the early stages of therapy. They should not perform potentially dangerous tasks until you have determined how this drug affects them.

Medicines used to treat and prevent asthma, such as b2 agonists such as salbutamol, cromolyn sodium, corticosteroids such as beclomethasone, budesonide, and fluticasone, should not be reduced immediately when Zaditen treatment is started.

Zaditen can increase the risk of seizures, especially if the patient has a history of seizures. Discuss with your doctor how this medical condition may affect the dosage and effectiveness of this medication, and if any special monitoring is needed.

Zaditen should not be used by anyone who is pregnant or breastfeeding.

Zaditen interactions

There may be an interaction between ketotifen and any of the following medications:

  • Anti-anxiety drugs.
  • Codeine.
  • Oral diabetes medications such as glyburide, metformin.
  • Muscle relaxants.
  • Psychiatric medications.
  • Antihistamines.
  • Alcohol.

If you are taking any of these medicines you should:

  • Stop taking one of the medications.
  • Change one of the drugs to another.
  • Change the way you are taking one or both medicines.