Xeristar: Indications, Dosage, Side Effects, Precautions and Interactions

It is a serotonin and norepinephrine reuptake inhibitor (SSNRI) antidepressant.

Xeristar affects chemicals in the brain that can become unbalanced and cause depression . Xeristar is used to treat major depressive disorder in adults and this drug is used to treat general anxiety disorder .

It is also used in adults to treat fibromyalgia (a chronic pain disorder) or chronic muscle or joint pain (such as low back pain and osteoarthritis pain). In addition, its consumption is also to treat pain caused by nerve damage in adults with diabetes (diabetic neuropathy).


Xeristar (brand names Xeristar, Yentreve, and in parts of Europe, Xeristar or Ariclaim) is a medicine that is primarily targeted at:

  • Major depressive disorder (MDD).
  • Generalized anxiety disorder (GAD).
  • Pain related to diabetic peripheral neuropathy.
  • Urinary stress or incontinence (SUI).

It is manufactured and marketed by Eli Lilly and Company. It has not yet been approved by the FDA for stress urinary incontinence or fibromyalgia. It is a systemic drug therapy that affects the body as a whole.

Also known under the code name LY248686, it is a potent dual reuptake inhibitor of serotonin (5-hydroxytryptamine, 5-HT) and norepinephrine (NE), possessing comparable affinities for binding to NE and 5-HT transporter sites.

How should I use the Xeristar?

  • Use Xeristar as directed by your doctor and check the directions on the medicine label. The packaging also comes with a medication guide, please read it carefully.
  • Without chewing, breaking or crushing it before ingesting. Do not sprinkle the contents of the capsule on food or in liquid.
  • Take Xeristar on a regular schedule to get the most benefit from it. Taking Xeristar at the same time each day will help you remember to take it.
  • Keep taking Xeristar even if you feel fine. Don’t miss any doses.

Ask your healthcare provider any questions you may have about how to use Xeristar.

Dosage and use

Do not chew or break the capsule, swallow the medicine whole. Do not spray the contents of the capsule on food or mix with liquids. All of these can affect the enteric coating.

If a dose is missed, take it as soon as possible and if the next dose is nearing, do not take twice the amount needed. Just take one.

Take the medicine exactly as your doctor has ordered and if you are not completely sure how to use it, check with your doctor.

With people who have depression or anxiety disorder, the drug usually works after a couple of weeks of use. Xeristar starts to work in most people who take the medicine with diabetic neuropathic pain one week after starting treatment.

For depression and diabetic neuropathic pain

Usually, the dose of this medicine in these cases is one capsule per day (60 mg of duloxetine), but depending on certain factors, the dose can vary and the doctor will prescribe the appropriate amount for your body.

For generalized anxiety disorder

Usually, for this type of case, at the beginning the dose is 30 mg per day. Subsequently, most patients will consume 60 mg doses once a day.

But, depending on each individual, the doctor will prescribe the appropriate amount for your body.

Xeristar is for oral use. You should swallow your capsule whole with a sip of a drink, preferably water. To help you remember to take Xeristar, you may find it easier to take it at the same time each day.

Talk to your doctor about how long you should keep taking Xeristar. If you have not consulted your doctor before, do not stop using it either gradually or suddenly.

Side effects

Xeristar can have side effects, although not all users of the drug get them. The effects are generally very mild or have a moderate level of presence in the consumer. These tend to disappear in a matter of weeks.

The effects are as follows

  • Having fatigue, anxiety, feeling agitated, or having abnormal dreams.
  • Having tremors or numbness, including numbness or tingling of the skin.
  • Diarrhea, constipation, being sick (vomiting), heartburn, stomach pain, stomach pain.
  • Tinnitus (perception of sound in the ear when there is no external sound).
  • Blurred vision.
  • Redness, increased sweating.
  • Problems getting an erection, decreased sex drive, and an abnormal orgasm.
  • Itchy skin rash.
  • Pain, tension, or spasms in the muscles.
  • Lack of appetite.
  • Weightloss.


You should not consume it if

  • You are allergic to duloxetine or another part of the drug.
  • You suffer from liver disease.
  • You suffer from severe kidney disease.
  • You are taking, or have taken in the last 14 days, another medicine known as a monoamine oxidase inhibitor.
  • Take fluvoxamine , which is usually used to treat depression, or ciprofloxacin or enoxacin, which is used to treat some infections.
  • Take another medicine that contains duloxetine.
  • If you have high blood pressure or heart disease, ask your doctor about taking Xeristar.

The following are reasons why Xeristar may not be suitable for you. Talk to your doctor before taking the medicine if you:

  • Take other antidepressants.
  • You are taking St. John’s wort, an herbal treatment.
  • You have kidney disease.
  • You have had seizures (fits).
  • Has or has had hobbies.
  • He suffers from bipolar disorder.
  • You have eye health problems, such as certain types of glaucoma.
  • You have a history of bleeding disorders (tendency to bruise).
  • You are at risk for low sodium levels (for example, if you are taking diuretics, especially if you are older).
  • They are currently being treated with another drug that can cause liver damage.
  • You are taking other medicines that contain duloxetine. The medicine may cause the feeling of being unable to sit up or stay still. Let your doctor know if it happens to you.

Thoughts of suicide and worsening of your depression or anxiety disorder

With suicidal intentions or attempts at self-harm, these types of thoughts can increase when antidepressants are first started, since all of these medications take time to work. Medicines usually start to work in about two weeks, but sometimes longer.

You are more likely to think this way if you have previously had thoughts about killing yourself or hurting yourself.

Studies have shown that in adults under 25 years of age who have psychiatric disorders who were treated with an antidepressant there is a higher risk of exhibiting behavior.

If you intend to injure yourself or even commit suicide, seek help from a doctor or go to the nearest help center.

Use in children and adolescents under 18 years of age

Xeristar should not be ingested by children and adolescents under 18 years of age, since the possibility of suffering side effects (such as suicidal thoughts and aggressiveness) are greater in minors.

Xeristar is only prescribed for minors if the doctor considers that it is in the best interests of the patient. If a minor was prescribed Xeristar, you can consult with other doctors and report any side effects.

The long-term safety effects with respect to cognitive development, behavioral development, maturation and growth of the drug in this age group have not yet been demonstrated.

Taking other medications

If you plan to take other medicines while using Xeristar or have recently taken other medicines (even those obtained without prescriptions), you need to inform your doctor.

You should also inform your doctor if you are taking any of the following medications

Monoamine oxidase inhibitors (MAOIs):  You should not take Xeristar if you are taking or have recently taken (in the last 14 days) another antidepressant medicine called a monoamine oxidase inhibitor (MAOI).

If you take MAOIs together with other prescription drugs (including Xeristar), it can cause serious or even fatal side effects.

You must wait at least 14 days after you have stopped taking an MAOI before you can take Xeristar. Before taking an MAOI you must wait at least 5 days after stopping Xeristar.

Medications that cause drowsiness: benzodiazepines, strong pain relievers, antipsychotics, phenobarbital, and antihistamines.

Medications that increase serotonin levels: triptans, tramadol, tryptophan, SSRIs (such as paroxetine and fluoxetine), tricyclics (such as clomipramine, amitriptyline), pethidine, St. John’s wort, and venlafaxine.

These drugs increase the risk of side effects; If you have any unusual symptoms taking any of these medicines together with Xeristar, you should consult your doctor.

Oral anticoagulants: help thin the blood. If taken together with Xeristar it may increase the risk of bleeding.

Consuming Xeristar with food or drink

Xeristar can be consumed with food or drinks, however, you have to be very careful with the consumption of alcohol while you are under drug treatments.

Taking the medicine with food can reduce nausea.

Pregnancy and breastfeeding

Before ingesting any medication if you are breastfeeding, you should consult your doctor.

If you become pregnant or are trying to become pregnant while taking Xeristar, talk to your doctor.

After the benefits and risks of using Xeristar in pregnancy have already been discussed with your doctor, you should consider its use. Make sure your doctor knows that you are a Xeristar user.

If other similar medicines are taken at the same time as Xeristar during pregnancy, they could lead to health problems for the newborn.

The risk that babies may develop a serious condition called persistent pulmonary hypertension of the newborn (which causes the baby to breathe faster than normal and appear blue) is greatly increased.

The baby could have some symptoms when it is born if Xeristar is swallowed. They usually start at birth or within a few days after your baby is born.

The symptoms they present usually include: nervousness, tremors, flexible muscles, lack of adequate nutrition, difficulty breathing and even seizures.

Tell your doctor if you are breast-feeding. The use of Xeristar during breastfeeding is not recommended. Before you start consuming while you are breastfeeding, you need to consult your doctor or pharmacist.

Driving and using machines

Until you determine how the medicine makes you feel, avoid handling tools or machines, especially if they are risky.

If you stop taking Xeristar

Do not stop taking the medicine capsules immediately without your doctor’s approval, even if you feel better. If your doctor considers that you do not need to consume more of the medicine, he will order you to decrease your dose gradually over at least 2 weeks before completely stopping the treatment.

Some patients who have stopped taking the drug suddenly have some of the following symptoms:

  • Dizziness
  • Tiredness and exhaustion.
  • Tingling sensation.
  • Sleep disorders (such as vivid dreams, nightmares, and even insomnia ).
  • Feeling restless or agitated
  • Feeling sick (having nausea).
  • Have tremors
  • Headaches.
  • Feeling of irritability.
  • Diarrhea.
  • Excessive sweating
  • Giddiness .

The above mentioned symptoms are not serious and tend to disappear after a few days. If your symptoms are very severe, you should see your doctor.