Venosmil: Uses, Pharmacodynamics, Contraindications, Precautions, Incompatibilities and Dosage

It is used for the short-term relief (two to three months) of edema and symptoms associated with chronic venous insufficiency (pain, weight in the legs, swelling, etc).

Venosmil or hydrosmin (due to its active component) is a drug belonging to the group of flavonoids and acts on the effects of venous blood stasis in the veins of the lower limbs (known as venous insufficiency), generally due to varicose veins or thrombosis old venous.

Pharmacodinámica

The active element of the drug is hydrosmin, whose chemical properties allow it to be classified as flavonoids. It is a standard mixture containing the components of 5,3’mono-O- (β-hydroxyethyl) -diosmine, as well as 5,3′-di-O- (β-hydroxyethyl) -diosmine.

The medicinal effect of hydrosmol has not yet been fully studied, but the presence of an interrelation with the decrease in catecholamine degradation can be observed, mainly due to the inhibition of catechol-O-methyltransferase activity.

While it has not yet been possible to determine the therapeutic effect of the drugs, it is still possible to identify the four basic properties provided by hydrosmine:

  • Strengthen the strength of the capillary walls, the permeability of which can be caused by the action of bradykinin with histamine. In addition, the substance prevents capillary fragility, which can develop with the wrong nutritional regimen.
  • Improving erythrocyte haemorrheological parameters, reducing blood viscosity, and increasing the ability of erythrocytes to deform.
  • Influence with respect to venomotor tone and gradual stimulation of permanent contractions of smooth muscles in the region of the venous wall.
  • Creation of optimal conditions to improve lymphoid circulation processes. Hydrosmin causes an expansion of the lymphatic ducts and, together with it, increases the speed of their movement, which improves lymphatic drainage.

Venosmil contributes to the improvement of the clinical manifestations of peripheral vein deficiency (feeling of heaviness or pain, as well as swelling). Undoubtedly, the active element of the drug has a significant effect on the complications of venous stasis, caused by varicose vascular dilation in the leg region.

Contraindications, precautions and incompatibilities

Venosmil should be taken with extreme caution, therefore consult your doctor if any of the following occur:

  • If you notice any hypersensitivity reaction to this medicine or any of its components.
  • If you have asthma or an allergy to aspirin.

Pregnancy

Use of venosmil during pregnancy

Clinical tests to determine the possibility of using venosmila in pregnancy are not available. In preclinical trials, no direct or indirect adverse effect was found on the course of pregnancy, fetal development, as well as the labor and postnatal development process.

Before starting to use drugs, you should evaluate the possible benefits and risks of the complications derived from their use.

Use of venosmil during breastfeeding

There is no information on the excretion of the drug with human milk, so it should not be used when breastfeeding.

Adverse effects

During the marketing period for hydrosmin, the following undesirable effects have been reported, although their frequency has not been clearly established.

The most commonly observed undesirable effects are:

venosmil capsules

  • Immune system disorders: hypersensitivity (allergic) reactions to the active substance or to one of the excipients.
  • Nervous system disorders: headache, dizziness.
  • Gastrointestinal disorders: epigastric pain, nausea.
  • Skin and subcutaneous tissue disorders: rash, pruritus.

venosmil gel

  • Immune system disorders: hypersensitivity (allergic) reactions to the active substance or to one of the excipients.
  • Skin and subcutaneous tissue disorders: rash, pruritus.

Report if you suspect adverse reactions

Warning on excipients

Some excipients of this medicine can cause allergic reactions, including asthma, especially in patients allergic to acetylsalicylic acid.

Venosmil dosage

You should follow venosmil treatment as prescribed by your doctor.

Orally

dults:

The usual dose of venosmil is one 200 mg capsule, three times a day, generally coinciding with meals.

Once removed from the blister, the capsule should be taken immediately, either with water or any other liquid to facilitate swallowing.

Overdose

No cases of overdose have been described. The good tolerance of venosmiL means that, in practice, the possibility of poisoning is non-existent, even in cases of accidental overdose.

Pharmacological properties

Presentation

  • Packages containing 20 and 60 capsules.

Other presentations

  • Venosmil gel, 60 g tube.

Venosmil storage

  • Protect it from heat and humidity. Store below 25 C.

Expiration

  • This medicine should not be used after the expiration date on the package.
  • Keep Venosmil out of the sight and reach of children.
  • This is a prescription drug.