Venosmil: Uses, Pharmacodynamics, Contraindications, Precautions, Incompatibilities and Dosage

It is used for the short-term relief (two to three months) of edema and symptoms associated with chronic venous insufficiency (pain, weight in the legs, swelling, etc.).

Venosmil or hydrosmin (due to its active component) is a drug belonging to the group of flavonoids and acts on the effects of venous blood stasis in the veins of the lower limbs (known as venous insufficiency), generally due to varicose veins or thrombosis old venous.


The active element of the drug is hydrosmin, whose chemical properties allow it to be classified as a flavonoid. It is a standard mixture containing the components of 5,3’mono-O- (β-hydroxyethyl) -diosmin and 5,3′-di-O- (β-hydroxyethyl) -diosmin.

The medicinal effect of hydrosol has not yet been thoroughly studied. Still, an interrelation with the decrease in catecholamine degradation can be observed, mainly due to the inhibition of catechol-O-methyltransferase activity.

While it has not yet been possible to determine the therapeutic effect of the drugs, it is still possible to identify the four basic properties provided by hydro mine:

  • Strengthen the strength of the capillary walls, the permeability of which can be caused by the action of bradykinin with histamine. In addition, the substance prevents capillary fragility, which can develop with the wrong nutritional regimen.
  • We are improving erythrocyte hemorheological parameters, reducing blood viscosity, and increasing the ability of erythrocytes to deform.
  • Influence concerning the vasomotor tone and gradual stimulation of permanent contractions of smooth muscles in the region of the venous wall.
  • Creation of optimal conditions to improve lymphoid circulation processes. Hydrosmin causes an expansion of the lymphatic ducts and, together with it, increases the speed of their movement, which enhances lymphatic drainage.

Venosmil improves the clinical manifestations of peripheral vein deficiency (feeling of heaviness or pain and swelling). Undoubtedly, the drug’s active element significantly affects the venous stasis complications caused by varicose vascular dilation in the leg region.

Contraindications, precautions, and incompatibilities

Venosmil should be taken with extreme caution; therefore, consult your doctor if any of the following occur:


  • If you notice any hypersensitivity reaction to this medicine or its components.
  • If you have asthma or an allergy to aspirin.


Use of venosmil during pregnancy

Clinical tests to determine the possibility of using venosmila in pregnancy are unavailable. In preclinical trials, no direct or indirect adverse effect was found on the course of pregnancy, fetal development, and the labor and postnatal development process.

Before starting to use drugs, you should evaluate the possible benefits and risks of the complications derived from their use.

Use of venosmil during breastfeeding

There is no information on the excretion of the drug with human milk, so it should not be used when breastfeeding.

Adverse effects

During the marketing period for hydrosmin, the following undesirable effects have been reported, although their frequency has not been established.

The most commonly observed undesirable effects are:

venosmil capsules

  • Immune system disorders: hypersensitivity (allergic) reactions to the active substance or one of the excipients.
  • Nervous system disorders: headache, dizziness.
  • Gastrointestinal disorders: epigastric pain, nausea.
  • Skin and subcutaneous tissue disorders: rash, pruritus.

venosmil gel

  • Immune system disorders: hypersensitivity (allergic) reactions to the active substance or one of the excipients.
  • Skin and subcutaneous tissue disorders: rash, pruritus.

Report if you suspect adverse reactions

Warning on excipients

Some excipients of this medicine can cause allergic reactions, including asthma, especially in patients allergic to acetylsalicylic acid.

Venosmil dosage

You should follow venosmil treatment as prescribed by your doctor.



The usual dose of venosmil is one 200 mg capsule, three times a day, generally coinciding with meals.

Once removed from the blister, the capsule should be taken immediately with water or any other liquid to facilitate swallowing.


No cases of overdose have been described. The excellent tolerance of venosmiL means that, in practice, the possibility of poisoning is non-existent, even in cases of accidental overdose.

Pharmacological properties


  • Packages containing 20 and 60 capsules.

Other presentations

  • Venosmil gel, 60 g tube.

Venosmil storage

  • Could you protect it from heat and humidity? Store below 25 C.


  • This medicine should not be used after the expiration date on the package.
  • Keep Venosmil out of sight and reach of children.
  • This is a prescription drug.