It is an antianginal drug that has a protective effect on the cellular structure and functions of various tissues or organs.
Within the group of organs that the drug covers is the myocardium , it protects it from the effects of hypoxia, ischemia or the metabolic disturbances that derive from them.
That is, it is a cardiac metabolism modulator drug which does not have direct hemodynamic effects.
Trimetazidine is used for the long-term treatment of angina . Angina is chest pain that arises from the heart muscle when it does not receive enough oxygen.
It can cause the feeling of indigestion, fullness, pressure, or tightness in your chest that spreads to your arms or neck.
It works by producing a good supply of oxygen for the cells of the heart.
Trimetazidine makes better use of oxygen and energy in the cells of the heart. This helps decrease the number of times angina occurs.
Trimetazidine is also used for the treatment, prevention, control and improvement of the following symptoms:
- Severe pain in the chest
- Ringing in the ears.
- Inner ear problems.
However, trimetazidine is generally prescribed as a long-term treatment for angina pectoris.
Mechanism of action
Trimetazidine reduces beta-oxidation of fatty acids by blocking long-chain 3-ketoacyl-Co Atiolase, which increases glucose oxidation.
In an ischemic cell, the energy obtained during glucose oxidation requires less oxygen consumption than in the beta-oxidation process.
Trimetazidine and stable angina
The efficacy of trimetazidine as an antianginal drug has been evaluated in randomized, placebo-controlled studies.
It has also been studied as a treatment alone and in combination with beta blockers and calcium channel blockers.
Several studies have tested the efficacy of trimetazidine and have shown that this agent is at least as effective and better tolerated than hemodynamic agents.
In stable angina, it improves exercise tolerance and raises the ischemic threshold to an extent comparable to beta-blockers and calcium channel blockers.
The combination of trimetazidine and a beta blocker appears to be more effective than the combination of nitrates and a beta blocker.
The presence of trimetazidine improves symptoms in patients resistant to diltiazem or metoprolol.
Dosage and how to use
- The drug should be taken after meals with water.
- You need to follow the directions on the prescription label.
- It is not recommended to stop taking the medicine without consulting a doctor beforehand.
- If a dose is missed, it is necessary to take it as soon as possible.
In relation to the last recommendation, if almost one hour has passed for the next dose, only the usual dose should be taken.
Do not double the dose or use additional medications to make up for a missed dose.
Side effects of trimetazidine
Besides the desired effect, trimetazidine can also cause some unwanted effects. In such cases, you should seek medical attention immediately.
There are various side effects derived from the treatment and some are not specific to it. However, a list of the most frequently occurring effects is presented.
Therefore, a doctor should be consulted if any adverse drug reaction is experienced such as:
- He retched.
- Soft spot.
- Constipation .
- Low blood pressure with position change.
- Skin itch.
- Allergic skin reactions.
A doctor should be consulted about all medications, allergies, medical history, especially if the patient:
- You are allergic to trimetazidine or any other medications.
- You are pregnant or breastfeeding.
- You have Parkinson’s disease.
- You have a severe kidney problem.
It is recommended to consult a doctor or if you observe any of the side effects mentioned above, while taking this medicine, especially if they do not go away.
It is advisable to discontinue this medication if there is no response after three months of treatment.
It is dangerous to drive or operate heavy machinery while taking this medicine, as it can cause higher risk situations.
Patients with moderate kidney problems should be especially careful if they are under this treatment, as well as those who are over 75 years of age.
Handling and Storage of Trimetazidine
The following indications are necessary for the proper maintenance of treatment:
- It is necessary to keep the medicines in the original container, tightly closed or sealed in a cool and dry place, away from direct sunlight.
- The medicine should be kept out of the reach of children.
- It is advisable to dispose of the medicine when it has expired.