Triamcinolone Acetonide: Indications, Contraindications, Doses, Warnings, Interactions and Adverse Reactions

Pharmacology

Triamcinolone acetonide is a synthetic corticosteroid with anti-inflammatory and allergic action with antipruritic drugs. The present mixture acts as an adhesive film to apply the active medicament to the oral tissues. The film provides a protective cover that can be used to reduce pain associated with oral irritation temporarily.

Indications

Triamcinolone acetonide is indicated for the adjunctive treatment and temporary relief of symptoms associated with trauma’s oral inflammatory and ulcerative lesions.

Contraindications

The product is contraindicated for those patients who have a history of hypersensitivity to some or any of its components. Because it contains a corticosteroid, the preparation is contraindicated in the presence of fungi and viral or bacterial infections of the mouth or throat.

Dose

Apply a small amount (approximately 6 mm) of triamcinolone acetate without rubbing over the lesion to create a thin film. A more significant amount may be required to cover some injuries. For optimal results, use only enough to cover the lesion with a thin film, and it should not be rubbed. Attempting to extend this preparation can result in a gritty, granular feeling and cause it to crumble. However, after the application of the product develops a smooth and slippery film.

This preparation should be applied before bedtime to allow steroid contact with the injury during the night. Depending on the severity of the symptoms, it may be necessary to use the preparation 2-3 times a day, preferably after meals. If there is no significant repair and regeneration within seven days, it is advisable to investigate new treatment options.

Warnings

Patients with tuberculosis, peptic ulcer, or diabetes mellitus should not be treated with any preparation of corticosteroids without the doctor’s advice. It must be taken into account that the normal defensive responses of oral tissues are diminished in patients receiving topical glucocorticoid treatment.

 

The virulent strains of oral microorganisms can multiply without producing the usual warning symptoms of oral infections. The small amount of steroid released when the preparation is used as recommended makes it very unlikely that this appearance will generate systemic effects; however, there is a possibility when topical corticosteroid preparations are used for a prolonged period.

If irritation or sensitization develops, the preparation should be discontinued, and therapy should be appropriately replaced.

Use in the elderly and young.

Although there is no specific information comparing corticosteroids for dental use in elderly patients with younger patients, these drugs are not expected to cause different problems or adverse effects than those observed in younger patients.

Use during pregnancy and lactation.

The safe use of triamcinolone has not been established during pregnancy, as there is a possibility of adverse effects on the developing fetus; therefore, the product should not be used in women with gestational capacity and in particular at the beginning of the pregnancy unless, in the opinion of the doctor or dentist, the potential benefits outweigh the risks.

Interactions

  • There are no data in the literature on drug interactions.
  • There are no data in the literature on feeding interactions.
  • There are no data in the literature about changes in laboratory tests.

Adverse reactions

Prolonged administration can lead to adverse reactions with the known preparations with systemic steroids, for example, adrenal suppression, impaired glucose metabolism, protein catabolism, activation of peptic ulcer, and others.

These are usually reversible and disappear when the hormone is suspended.

Overdose

Since there is a specific antidote and adverse events are unlikely, the treatment is dilution by fluids.

Storage

Keep tightly closed at room temperature (15 ˚ C and 30 ˚ C). Protect from light and keep it in a dry place.