It is a drug that combines an antidiarrheal and a bactericide, contains a base of kaolin and pectin, accompanied by a dose of neomycin.
Neomycin is no more than an effective antimicrobial against the most common pathogenic bacteria in gastrointestinal infections such as:
Escherichia coli, Enterobacter aerogenes, Klebisiella sp., Salmonella sp., Serratia sp., Shigella sp., Proteus vulgaris (Gramnegativas) y Staphylococcus aureus, Staphylococcus epidermidis y Enterococcus faecalis (Grampositivas).
The neomycin present in the composition of the drug is an antibacterial with local digestive action; antidiarreico, antihiperamonémico and lipid-lowering.
The kaolin and the Pectin that contains the drug are fine inert powders, these compounds adhere to the skin and mucous membranes, and act mechanically, without interfering in any digestive or metabolic process.
These powders are able to remove and promote the expulsion of bacteria and irritants that are in the mucous membranes and are common causes of diarrhea thanks to its absorbing properties.
They are also protectors of the gastrointestinal tract and have demulcent and astringent properties necessary to normalize the consistency of stool.
These components significantly reduce the number of evacuations, thus avoiding the loss of fluids and electrolytes when diarrheic symptoms occur.
Tredra can be used for all types of acute diarrhea, both infectious and non-infectious.
Composition of Treda
Neomycin 129 mg, colloidal kaolin 280 mg and anhydrous citric pectin 30 mg.
The route of administration is oral.
- In children between the ages of 6 and 11, one teaspoon should be administered every 4 or 6 hours.
- In Adults and children over 12 years of age, the recommended dose is two teaspoons every 4 to 6 hours.
- In children between the ages of 6 and 11, one tablet will be administered every 4 or 6 hours.
- In Adults and children over 12 years of age the dose of two tablets is recommended every 4 to 6 hours.
Neomycin should not be administered in children under 6 years of age and it should be taken into account that the maximum dose is 100 mg / kg per day. Its use for more than 3 weeks should be avoided as much as possible, due to the percentage of the drug that is absorbed.
Mechanism of action of Treda
Neomycin inhibits protein synthesis in bacteria by irreversibly binding to the 30 S ribosomal subunit of bacteria that are susceptible.
Neomycin is transported actively to the bacterial cell, where it binds to the receptors present in the 30 S. ribosomal subunit.
This binding interferes with the initiation complex that occurs between messenger ribonucleic acid (mRNA) and 30 S subunit.
As a result of this interference, abnormal proteins that are not functional are formed, due to the misinterpretation of the bacterial DNA.
This drug is indicated in the treatment of diarrhea caused by strains that are susceptible to Escherichia coli, Salmonella , Shigella, Paracolon, Enterobacter and Proteus vulgari, Enterobacter and Klebsiella.
Contraindications of Treda
Treda should not be administered in the following cases:
- Hypersensitivity to neomycin or to the components of the formula.
- In cases of intestinal obstruction, severe abdominal pain.
- Presence of intense fever.
- Its use is restricted in children under 6 years.
- It should not be administered during pregnancy and lactation, as some amino glycosides cross the placental barrier.
If diarrhea persists for more than 3 days, treatment should be discontinued after treatment if signs of kidney damage appear.
Prolonged use of this drug can develop organisms resistant to neomycin.
Do not administer the product for more than 5 days, and do not exceed the prescribed dose.
Normally there are no side effects but occasionally nausea, vomiting and abdominal pain may occur.
Occasionally you may have constipation.
Neomycin may increase the effect of coumarin anticoagulants such as acenocoumarol, dicumarol and warfarin sodium.
Neomycin can also inhibit the absorption of digoxin and penicillin partially.
No serious cases of intoxication with treda have been reported.
However, neomycin in high doses can cause intestinal malabsorption and may lead to the appearance of resistant strains.
If some of these effects occur, the treatment should be discontinued immediately.