Tobramycin: Indications, Precautions, Side Effects, Interactions and Dosing

Like other Aminoglycosides, it is used to treat serious systemic infections caused by Gram-negative bacteria.

Indications and clinical uses

It is often administered simultaneously with beta – lactam antibiotics to produce a synergistic effect.

The infections treated include pneumonia, soft tissue infections. Like many antibiotics, use in animals has been derived mainly from empirical use and pharmacokinetic-pharmacodynamic information.

Tobramycin has also been used topically. It has been used in nebulization solutions for respiratory infections.

For nebulization, there is a unique formulation that is used in people that does not contain preservatives and is intended to treat infections caused by Pseudomonas aeruginosa in the airways of patients with cystic fibrosis .

After administration via this route, Tobramycin remains concentrated mainly in the respiratory tract, and plasma or serum concentrations are very low and are unlikely to cause toxicity.

Tobramycin ophthalmic will not treat a viral or fungal infection of the eye.


This medication is only for:

  • Treat bacterial infections.

You should not use this medication if you are allergic to Tobramycin, or if you have:

  • A viral or fungal infection in your eye.

To make sure Tobramycin Ophthalmic is safe for you, tell your doctor if you have ever had:

  • An allergy to similar antibiotics such as Amikacin, Gentamicin, Kanamycin, Neomycin, Streptomycin, Vancomycin.
  • Tell your doctor if you are pregnant or plan to become pregnant.

Tobramycin ophthalmic can pass into breast milk and cause side effects in the nursing baby. You should not breast-feed while using this medication.

Tobramycin ophthalmic is not approved for use by children under 2 months.

Side effects

Seek emergency medical attention if you have symptoms of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue or throat.

Call your doctor immediately if you have:

  • Severe burning, stinging or irritation after using this medicine.
  • Swelling.
  • Redness
  • Severe discomfort
  • Scab formation or drainage (may be signs of infection).

Common side effects may include:

  • Itching or redness.
  • Slight burning, stinging or irritation.
  • Itching or swelling of the eyelids.
  • Blurry vision.
  • Your eyes may be more sensitive to light.


  • Avoid wearing contact lenses until you no longer have symptoms of eye infection.
  • This medicine may cause blurred vision and may affect your thinking or reactions. Be careful if you drive or do something that requires you to be alert and able to see clearly.
  • Do not use other eye medications unless your doctor tells you to.
  • It is unlikely that other drugs taken orally or injected will have an effect on Tobramycin used in the eyes, but many drugs can interact with each other.
  • Tell each of your health care providers about all the medicines you use, including prescription and over-the-counter medications, vitamins, and herbal products.


Follow all instructions on your prescription label. Do not use this medication in larger or smaller amounts or for longer than recommended.

Ophthalmic Tobramycin is usually given 1 to 2 drops in the affected eye every 4 hours. For a serious infection, you may need to use 2 drops every hour for a short period before reducing the dose and the number of drops per day. Your doctor will tell you how long to continue using the medication.

Follow your doctor’s dosage instructions very carefully:

  • If you wear contact lenses, remove them before applying Tobramycin ophthalmic.
  • Ask your doctor if contact lenses can be reinserted after applying the medication.
  • Wash your hands before using eye medications.

To apply eye drops:

  • Drop your head back, opening the lower eyelid to open a little space between the eye and the eye.
  • Hold the dropper whose tip is pointed towards your eye while looking in another direction.
  • Keep your eyes closed for 3 minutes with your head facing the floor, without opening or touching your eyes.
  • Try not to exceed the dose recommended by your doctor, ideally wait 4 minutes between each drop provided.
  • If you use another type of ophthalmic medication, wait 12 minutes before using them after your first treatment.
  • Never wipe the excess solution with your hands, use a clean cloth.
  • It is considered the possibility that your sight is somewhat diffuse for a brief moment, therefore avoid performing tasks such as operating or operating some type of machine that requires your complete visual attention.

Ophthalmic Tobramycin will treat a viral infection such as the flu or a common cold.

Store at room temperature away from moisture and heat. Keep the bottle or tube tightly closed when not in use.