Thyrothricin: History, Pharmacology, Uses, Action Mechanism, Side Effects, Administration and Precautions

It is available in two forms: gel and powder; it is a medicine that effectively treats wounds and burns in adults and children.

No matter how much we try to avoid it, we ​​sometimes have several skin lesions such as lacerations, scratches, abrasions, deep wounds, or burns in everyday life.

Having reliable support and rescuer in your family medical kit is essential to prevent infection of the damaged area or treat an already infected wound.

History and pharmacology

Dubos first discovered Thyrothricin in 1939. He isolated an alcohol-soluble and water-insoluble substance from the autolyzed cultures of an anaerobic, mobile, soil spore-forming bacillus that had been called Bacillus Brevis.

This was highly active and bactericidal against several gram-positive organisms, including Staphylococcus, Streptococcus, and Diplococcus pneumoniae. Dubos called this substance Gramicidin.

However, an additional investigation by Dubos and Hotchkiss showed that a second substance was also present. This substance had some degree of activity against gram-negative organisms and was called Tyrosine. Due to the two substances, the name of the bactericidal extract was changed to Thyrothricin.

Additional research indicated that Thyrothricin contains approximately 85 percent Tyrosidine and 15 percent Gramicidin. A single injection of 0.1 mg of Tyrosidine administered intraperitoneally is sufficient to protect the mice against 10,000 doses.


Thyrothricin is a natural topical antibiotic whose significant advantage is the lack of toxic effects in the body. It is not absorbed into the bloodstream, and its action occurs exclusively within the infection outbreak.

This has a broad spectrum of antibacterial action and has a destructive effect on certain species of fungi.

In addition to that, unlike systemic antibiotics, which generally slow the organization of new cells in the wound, preventing the regeneration process, Thyrothricin accelerates wound healing through deep cleaning and stimulates the granulation phases and epithelization.

Uses of thyrotropin

This drug can treat different superficial wounds, infected eczemas, or burns. Also, to accelerate the recovery of trophic ulcers, even in the case of varicosities and diabetes.

It is used for gastric mucosa, throat inflammation, angina, and other conditions. It can also be used for other purposes not precisely mentioned in this information about the medication.

It serves in the treatment, control, prevention, and improvement of the following diseases, conditions, and symptoms:

  • Gastric mucosa
  • Inflammation of the throat.
  • Angina tonsillitis.
  • Cold sores.

Mechanism of action

Thyrothricin improves the condition that affects the patient by interrupting the bacterial cell membrane function. What causes its destruction of it.

Side effects of thyrotropin

The following is a list of possible side effects from all the ingredients that make up Thyrothricin.

These side effects are possible, but they do not always occur or occur in the patient. You should know that some side effects may be rare but serious.

Consult your doctor if you notice any of the following effects, especially if they do not go away:

  • Allergic reactions.
  • Hepatic injury.
  • Kidney damage

Thyrothricin can also cause some side effects that were not mentioned here.

Administration and precautions

Before using thyrotropin, you should inform your doctor about your current list of medications, over-the-counter products (vitamins, herbal supplements, among others), allergies, pre-existing conditions, and current health conditions (pregnancy, upcoming surgery, etc.).

Well, some health conditions can interfere with thyrythricin and make you more susceptible to the side effects of the medication.

It would help if you took thyrotropin according to your doctor’s instructions or followed the address printed on the product’s label. The dose is based on your condition.

Tell your doctor if your condition persists or worsens.

Consult your doctor before using this medicine on open wounds, dry, chapped, irritated, or sunburned skin.

Wash your hands before and after applying thyrotropin. Clean and dry the area of ​​the skin to be treated.

Do not wash the treated area after applying Tirothricin immediately. Also, avoid using other products in the treated area unless directed by your doctor.

Applying an excessive amount can result in allergies. Use a thinner coat or a lesser amount of medication to prevent the formation of pellets.

Avoid getting this medication in your eyes, nose, or mouth.

Interactions with other medications

If you take other drugs or over-the-counter products simultaneously, the effects of Thyotricin may change. This can increase your risk of side effects or make your medication not work correctly.

Tell your doctor about all the medicines, vitamins, and herbal supplements you are using, so your doctor can help you prevent or control drug interactions.

Frequent questions

Can thyrothricin be consumed or applied during pregnancy?

Consult your doctor for specific recommendations on pregnancy. No investigations have been reported or done based on it.

Is thyrotropin safe during breastfeeding?

Please discuss the risks and benefits with your doctor. No investigations have been reported or done based on it.

Can thyrotropin be used for the gastric mucosa and inflammation of the throat?

Yes, gastric mucosa and throat inflammation are among the most common uses reported for thyrotropin. However, do not use thyrotropin for gastric mucosa and throat swelling without checking with your doctor.

Is it safe to drive or operate heavy machinery when it is consumed?

If you experience drowsiness, dizziness, hypotension, and headache as side effects when using the medication, it is not safe to drive a vehicle or operate heavy machinery.

You should not drive a vehicle if the use of the medication makes you feel drowsy, dizzy or your blood pressure goes down too much.

Pharmacists also advise patients not to drink alcohol with medication since alcohol intensifies the side effects of drowsiness.

Please check these effects on you when you use Thyrothricin. Always check with your doctor to get specific recommendations for your body and health conditions.

Is this medication addictive or create habits?

Most medications do not have the potential for addiction or abuse. The government generally classifies drugs that can be addictive as controlled substances.

Examples include schedule H or X in India and schedule II-V in the US. UU Check the product package to ensure the medication does not belong to particular drug categorizations.

Finally, do not self-medicate and increase your body’s dependence on medications without the advice of a doctor.

Can I stop immediately, or do I have to reduce consumption slowly?

Some medications should be reduced or stopped immediately due to rebound effects. Consult your doctor for specific recommendations for your body, health, and other medications you may be using.


Missing a dose:

If you miss a dose, take it as soon as you notice it. If the time for your next dose is near, skip the missed one and resume your dosing schedule. Do not use an extra dose to make up for the missed dose.

If you regularly miss doses, consider setting up an alarm or asking a family member to remind you. Consult your doctor to discuss changes in your dosing schedule or a new schedule to make up for missed doses if you have omitted too many recently.


Do not use more than the prescribed dose. Taking more medications will not improve your symptoms but may cause poisoning or serious side effects.

If you suspect that you or someone else may have overdosed on Thyrothricin, go to the nearest hospital emergency department or nursing home.

Carry a first aid kit, container, or label to help doctors with the necessary information.

Do not give your medications to other people, even if you know they have the same condition or it seems they may have similar conditions. This can lead to an overdose.


Store this medicine at room temperature, away from heat and direct light. Do not freeze unless required by the prospect. Keep the medication away from children and pets.

Do not throw Thyrothricin into the toilet or pour it into the drain unless instructed. Medication discarded in this way can contaminate the environment.

Please consult your pharmacist or doctor for more information on safely disposing of Thyrothricin.

Thirotricin expired:

Taking a single dose of expired Thyrothricin is unlikely to produce an adverse event. However, talk to your primary care provider or pharmacist to get proper advice if you feel sick or ill.

The expired medication may become ineffective in the treatment of your prescribed conditions. To be sure, it is essential not to use expired medications.

Suppose you have a chronic disease that requires constant medications, such as heart disease, seizures, and life-threatening allergies. In that case, staying in touch with your primary care provider is much safer than having a new supply of medications that have not expired.