Sulfadiazine: Administration, Side Effects, Warnings, Recommendations and Interactions

It is an antibiotic that fights some bacteria in the body.

This medication is used to treat infections such as urinary tract infections , toxoplasmosis, and others.

Side effects of sulfadiazine

If you experience any of the following serious side effects, stop taking Sulfadiazine and seek emergency medical attention or contact your doctor immediately:

  • Allergic reactions such as difficulty breathing, closing of the throat, hives , swelling of the lips, face and tongue.
  • Rash.
  • Fainting.
  • Blood in the urine.
  • Difficult or painful urination
  • Yellowing of the skin or eyes.
  • Ringing in the ears.
  • Difficulty breathing, sore throat or chills.
  • Rash on the skin.
  • Unusual tiredness or weakness
  • Severe watery diarrhea and abdominal cramps.
  • Unusual bleeding or bruising

There is a likelihood of other mild side effects

Continue taking sulfadiazine and talk to your doctor if you feel:

  • Headache, fatigue or dizziness.
  • Nausea, vomiting, decreased appetite or diarrhea.
  • Increased sensitivity of the skin to the sun.

Important information

Take all doses of sulfadiazine prescribed to you, even if you start to feel better. Your symptoms may begin to improve before the infection is treated completely.


Do not take sulfadiazine without first talking to your doctor if you have ever had an allergic reaction to a diuretic (water pill), a sunscreen that contains PABA or another medicine.

Before taking sulfadiazine, tell your doctor if you have:

  • Renal disease.
  • Liver disease
  • Glucose 6-phosphate dehydrogenase deficiency (G6PD deficiency).
  • Blood problems

You may not be able to take sulfadiazine, or you may need a dose adjustment or special monitoring during treatment if you have any of the conditions listed above.

It is not known if sulfadiazine will harm an unborn baby. Do not take sulfadiazine without first talking to your doctor if you are pregnant or could become pregnant during treatment.

It is not known whether sulfadiazine will be harmful to the infant. Do not take a sulfadiazine without first talking to your doctor if you are breast-feeding a baby.


Take sulfadiazine exactly as directed by your doctor, so you should only be clear about the indications.

At the time of taking the dose you should swallow it with a full glass of water. Drink several extra glasses of water each day while taking sulfadiazine to decrease the risk of developing kidney stones.

Sulfadiazine should be taken at equally spaced intervals throughout the day and night to keep the amount of medication in the blood high enough to treat the infection.

It is important to take sulfadiazine regularly to get the most benefit.

Contact your doctor if your symptoms do not improve or if they seem to get worse.

Sulfadiazine should be stored at room temperature in a place free of moisture and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the dose you missed and take only the next regularly scheduled dose. Do not take a double dose of this medication unless your doctor tells you otherwise.

What happens if you have an overdose?

If the dose was exceeded without medical advice, you may have symptoms of an overdose. Contact your doctor or go to the medical center closest to your home.

Symptoms of an overdose of sulfadiazine include:

  • Decreased appetite.
  • Sickness.
  • Vomiting
  • Dizziness
  • Headache.
  • Drowsiness.
  • Fever.
  • Unconsciousness.


If possible, avoid prolonged exposure to sunlight. Sulfadiazine may increase the sensitivity of the skin to sunlight. The use of sunscreen and appropriate clothing is recommended to protect yourself when sun exposure is imminent.


Before taking sulfonamide, tell your doctor if you are taking any of the following medications:

  • Ciclosporina (Neoral, Sandimmune).
  • Metotrexato (Rheumatrex, Trexall).
  • Warfarina (Coumadin).
  • Oral oral medication such as glipizide (Glucotrol), gliburide (Glynase, Micronase, Diabetes).
  • Clorpropamida (Diabinese), tolbutamida (Orinase) o tolazamida (Tolinase).
  • Phenytoin (Dilantin)

In addition to the drugs listed above, others may also interact with sulfadiazine. It is important to inform your doctor if you are taking other chemical or natural medicines.