It is a medicine used to relieve painful spasms of the digestive tract, genitourinary tract, and bile ducts.
Sertal is a medicine made up of propinox.
It is an antispasmodic drug that is frequently used in the treatment of disorders of the gastrointestinal tract, uterus, and gallbladder, but little is known about its relaxing activity in gallbladder tissue.
What is a stomach spasm about?
A stomach spasm has the characteristic of involuntary, painful and uncontrollable cramps in the abdomen area. These contractions are caused by an inflammatory process in the lining of the stomach.
Often the causes are:
- Bacterial development.
- Gas accumulation or aerophagia.
- Poor digestion
Sertal dosage (drops)
A dose of 20 drops 3 to 5 times a day is regularly recommended.
However, it is suggested to follow the therapeutic indications of the health specialist, since there are factors such as the patient’s health condition, age, height and weight that may imply the expected results.
Sertal can be used in children following the strict indications of the pediatrician.
Sertal side effects
In case of a high dose the side effects can be:
- Dry mouth
- Visual focus decreased.
- Acceleration of the heart rate.
When the dose is lower than what is required by the patient, it can generate effects such as:
- Eye strain.
- Memory problems.
- Urinary retention.
This medicine is contraindicated in the following cases:
- Hypersensitivity to propinox.
- Hyperthyroidism: Increased thyroid hormones.
- Pregnancy and breastfeeding.
- Heart failure.
- Arterial hypertension.
- Ischemic heart disease.
- Mitral valve narrowing.
- Gastroesophageal reflux.
- Read the package leaflet and the indications of the medicine.
- Do not take a dose other than that prescribed by your doctor.
- If you notice other effects that are not listed in this informational material, go to the nearest medical center.
Composition and presentations of the sertal
- Coated tablets : each contains 10mg of propinox hydrochloride.
- Injectable : each 1ml ampoule contains 10mg of propinox hydrochloride.
- Drop solution: each 100 ml contains 1g of propinox hydrochloride.
- Always check the expiration date of the medicine.
- Store at 25 ° C.
- Avoid exposure to light.
- Keep out of the reach of children.
General information and studies on the sertal
The antispasmodic activity of propinox, (-) scopolamine-n-butyl bromide, atropine and verapamil was determined in human gallbladders to reduce the risk of interspecies variability.
The inhibitory activities (ED50) of the contraction induced by carbachol were: atropine 5.03 x 10 (-8) M> propinox 1.25 x 10 (-7) M> verapamil 6.63 x 10 (-6) M> (-) scopolamine-n -butyl bromide 5.4 x 10 (-5) M. pD ‘2 for propinox was 6.94, indicating a non-competitive inhibition of carbachol action.
Radioligand binding studies were performed to determine whether the antispasmodic action of the drug involved binding to muscarinic receptors or calcium antagonist sites.
The inhibition constant (Ki) of propinox for the muscarinic receptors of the smooth muscle of the guinea pig ileum, which contains a mixed population of M2-M3 receptors, was 1.6 x 10 (-6) M. Ki for the brain muscarinic receptors (M1) was 1.0 x 10 (-4) M.
Likewise, for cardiac receptors (M2) 1.2 x 10 (-6) M and for salivary gland receptors (M3) 1.5 x 10 (-6) M.
For binding to the calcium antagonist dihydropyridine binding sites, the Ki was: 4.9 x 10 (-5) M for propinox and 2.2 x 10 (-7) M for verapamil. For the phenylalkylamine binding sites, Ki were: 5.0 x 10 (-6) M for propinox and 3.5 x 10 (-8) M for verapamil. For the benzothiazepine binding sites, the Ki for propinox was 5.2 x 10 (-6) M.
Conclusions from studies on sertal
The following can be concluded:
- The antispasmodic activity of propinox in the isolated human gallbladder was comparatively less potent than that of atropine and more potent than that of verapamil and (-) scopolamine-n-butyl bromide.
- Propinox showed binding to muscarinic and calcium receptors that may be related to its antispasmodic activity; Which suggests that the drug is an antispasmodic with anticholinergic and musculotropic activity.
- The dual mechanism of action, anticholinergic and calcium blocker, would induce synergy of pharmacodynamic effects and minimize adverse events of pure antimuscarinic drugs or calcium antagonists.
Note : This material is for informational use only and in no way is a substitute for the care and information of your physician. Go to receive specialized care for a painful gastrointestinal process.