Salazopyrin: How to Use, Who Should not Take it, Side Effects, Warnings and Interaction

It is used to treat inflammatory bowel diseases, such as ulcerative colitis, proctitis or distal ulcerative colitis, and Crohn’s disease.

Salazopyrin belongs to the class of medications called anti-inflammatory drugs.

It helps control symptoms by reducing chronic inflammation in the intestine. Enteric-coated tablets can be used to treat rheumatoid arthritis when treatment with other medications has not helped. It may take 1 to 2 months before you see the results.

This medication may be available under multiple brands and in different forms. Any specific brand of this medication may not be available on all documents or approved for all conditions discussed here.

If you have not discussed this with your doctor or are unsure why you are taking salazopyrin, talk to your doctor. Do not stop taking this medication without consulting.

Do not give this medicine to anyone else, even if they have the same symptoms you have. It can be harmful to people to take salazopyrin if their doctor has not prescribed it.

How should I use salazopyrin?

The dose of salazopyrin varies widely depending on the condition being treated and the person’s needs. The amount usually starts at a low dose and increases to the most effective quantity.

 

Side effects are more likely to occur with total daily doses of 4 g (4,000 mg) daily or more.

Salazopyrin doses should be taken regularly and even during the 24-hour daily period.

If you are taking salazopyrin for inflammatory bowel disease, the range of the night dose should not exceed eight hours. Amounts for children are calculated based on body weight.

Uncoated tablets should be taken with a meal if possible. Enteric-coated tablets should not be chewed or crushed; They must be swallowed whole.

While taking salazopyrin, drink an adequate amount of fluids to minimize the risk of urinary crystals and the formation of kidney stones.

Many things can affect the dose of medication a person needs, such as body weight, other medical conditions, and other drugs.

If your doctor has recommended a different dose from those listed here, do not change how you take the medication without consulting your doctor.

It would help if you took salazopyrin precisely as prescribed by your doctor. If you miss a dose, take it as soon as possible and continue your usual schedule.

If it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double amount to make up for the one you forgot. If you are not sure what to do after skipping a dose, contact your doctor or pharmacist.

Store this medication at room temperature, protect it from light and moisture and keep it out of the reach of children.

Do not discard medicines in wastewater (for example, in the sink or the toilet) or household waste. Ask your pharmacist how to get rid of medications that are no longer needed or are no longer valid.

Who should not take salazopyrin?

Do not take salazopyrin if you:

  • You are allergic to salazopyrin or any ingredient in the medication.
  • You are allergic to sulfonamides or salicylates (for example, aspirin).
  • You have a liver condition called porphyria since this type of medication has been reported to cause seizures.
  • You have had acute asthma attacks, urticariarhinitis, or other allergic symptoms caused by ASA or other nonsteroidal anti-inflammatory drugs (NSAIDs, for example, ibuprofen, naproxen).
  • You have an intestinal or urinary blockage.
  • He has severely decreased kidney function.

Do not give salazopyrin to children under two years of age.

What side are effects possible with salazopyrin?

Many medications can cause side effects. A side effect is an unwanted response to a medication when taken in regular doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by all people taking Salazopyrin. If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor.

The following side effects have been reported by at least 1% of people taking salazopyrin. Many of these side effects can be controlled, and some may go away on their own over time.

Contact your doctor if you experience these side effects that are severe or bothersome. Your pharmacist can advise you on the management of side effects.

  • Diarrhea.
  • Dizziness.
  • Headache.
  • Increased sensitivity of the skin to sunlight.
  • Itch.
  • Loss of appetite
  • Nausea.
  • Orange-yellow color of the urine.
  • Stomachache.
  • Vomiting

Although most of the side effects listed below do not happen very often, they can cause severe problems if you do not see your doctor or seek medical attention.

Check with your doctor as soon as possible if you experience any of the following side effects:

  • Joint and muscle pain.
  • Difficulty in swallowing.
  • Headache (continuing)
  • Signs of coagulation problems (unusual nosebleeds, bruises, blood in the urine, coughing up blood, bleeding gums, cuts that do not stop bleeding).
  • Signs of kidney problems (for example, increased urination at night, decreased urine production, blood in the urine).
  • Signs of liver problems (e.g., nausea, vomiting, diarrhea, loss of appetite, weight loss, yellowing of the skin or whites of the eyes, dark urine, pale stools).
  • Acne.
  • Symptoms of anemia (such as weakness, paleness, and fatigue).
  • Symptoms of arthritis (such as joint pain, stiffness).
  • Symptoms of infection (such as fever, chills, or a general feeling of being sick)

Stop taking the medication and seek medical attention immediately if any of the following occurs:

  • Signs of interstitial lung disease (for example, difficulty breathing).
  • Signs of a severe allergic reaction (e.g., abdominal cramps, nausea, vomiting, or swelling of the face and throat).
  • Signs of a severe skin reaction such as blistering, peeling, a rash that covers a large area of ​​the body, a rash that spreads rapidly, or a rash combined with fever or discomfort.

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptoms that bother you while taking salazopyrin.

Are there other precautions or warnings for salazopyrin?

Before you start using a medication, tell your doctor about any medical conditions or allergies you may have.

Any medication you are taking if you are pregnant or breastfeeding, and any other important information about your health. These factors can affect the way you should use this medicine.

Allergies: Some people who are allergic to furosemide, water pills with a thiazide, or carbonic anhydrase inhibitors also experience allergic reactions to this medication.

Before taking salazopyrin, tell your doctor about any previous adverse reactions to any medication.

Contact your doctor immediately if you experience an allergic reaction, such as rash, itching, shortness of breath, or swelling of the face and throat.

Anemia: Salazopyrin can cause low levels of red blood cells. Contact your doctor as soon as possible if you experience decreased red blood cells (anemia) count, such as shortness of breath, unusual tiredness, or pale skin.

Your doctor will perform periodic blood tests to check the number of specific blood cells, including red blood cells, in your blood.

Asthma: Salazopyrin can cause respiratory distress for people with asthma.

If you have asthma, talk to your doctor about how this medication may affect your medical condition, how your medical condition may affect the dosage and effectiveness, and if any special monitoring is needed.

Bleeding: Salazopyrin can cause a small number of platelets in the blood, making it difficult to stop bleeding.

If you notice any sign of bleeding, such as frequent nosebleeds, unexplained bruises, or black, tarry stools, notify your doctor as soon as possible.

Your doctor will order routine blood tests to make sure potential problems are detected early.

Infertility: infertility has been observed in some men treated with salazopyrin. Stopping the drug seems to reverse these effects.

Deficiency of the enzyme glucose-6-phosphate dehydrogenase: people who do not have the enzyme G6PD should consult with their doctor about how this medicine can affect the dosage and the effectiveness of this medicine.

Infection: Salazopyrin can reduce the number of cells that fight infections in the body (white blood cells).

Tell your doctor immediately if you notice more frequent signs of infection, such as fever or chills, severe diarrhea, shortness of breath, prolonged dizziness, headache, stiff neck, weight loss, or apathy.

Your doctor will perform regular blood tests to check the number of specific blood cells in your blood.

Kidney disease: This medicine may reduce kidney function.

If you have kidney disease, talk to your doctor about how this medicine may affect your medical condition, how your medical condition may affect the dosage and effectiveness of this medicine, and if any special monitoring is needed.

You will probably need regular exams while taking this medicine to ensure that your kidneys are working correctly. People who have severe kidney problems should not use this medicine.

Liver disease: Salazopyrin may reduce liver function and may cause liver failure.

If you have liver disease, talk to your doctor about how this medication may affect your medical condition, how your medical condition may affect the dosage and effectiveness, and if any special monitoring is needed.

You will probably need to have regular liver tests while taking this medication. People with severe liver disease or poor liver function should not take salazopyrin.

Urine color: Salazopyrin can produce a yellow-orange color in the urine. Occasionally a similar discoloration of the skin has been reported.

Stool tablets: If you see enteric-coated tablets intact in your stool, contact your doctor.

Pregnancy: This medication should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking this medication, contact your doctor immediately.

Breast-feeding: This medicine passes into breast milk. If you are a nursing mother taking salazopyrin, it can affect your baby. Talk to your doctor about whether you should continue breastfeeding.

Children: This medication is not recommended for children with juvenile rheumatoid arthritis.

What other drugs may interact with salazopyrin?

There may be an interaction between salazopyrin and any of the following drugs:

  • Antibiotics
  • Azathioprine.
  • Celecoxib.
  • Varicella vaccine.
  • Cyclosporine.
  • Medications for diabetes.
  • Folic acid.
  • Heparin.
  • Mercaptopurine.
  • Methotrexate
  • Metilfolato.
  • Nitric oxide.
  • Non-steroidal anti-inflammatory drugs (NSAID, for example, diclofenac, ibuprofen, naproxen).
  • Olsalazine.
  • Phenytoin
  • Prilocaína.
  • Probenecid.
  • Other salicylates (eg, ASA, salsalate).
  • Sodium nitrite.
  • Sulfinpyrazone.
  • Warfarin

If you are taking any of these medications, talk to your doctor or pharmacist. Depending on your specific circumstances, your doctor may ask you to:

  • Stop taking one of the medications.
  • Change one of the medications for another.
  • Change the way you are taking one or both medications.
  • Leave everything like this.

An interaction between two medications does not always mean you should stop taking one of them. Talk to your doctor about how drug interactions are handled or controlled.

Medications other than those mentioned above may interact with salazopyrin.

Tell your doctor or prescriber about all prescription, over-the-counter (OTC), and herbal medications you are taking. Also, tell them about any supplements you’re taking.

Because caffeine, alcohol, and nicotine in cigarettes or illegal drugs can affect the action of many medications, you should inform your doctor if you use them.