Sacubitril: Uses, Administration, Side Effects, Precautions and Storage

It is a drug used to treat blood pressure by lowering sodium levels and dilating blood vessels by increasing a certain amount of protein that the body needs to perform this action.

Sure, doctors recommend the combination of Sacubitril and Valsartan to treat chronic heart failure because it reduces the risk of hospitalization or death when the disease worsens by progressively regulating or reducing symptoms.

Administration of Sacubitril

The patient should read the medicine instructions before starting the treatment and consult any doubts that may arise with their doctor or pharmacist.

Sacubitril can be ingested with or without food, twice a day at the stipulated schedule or as indicated by the treating physician and for a specified time to ensure the effectiveness of the treatment.

The patient should not ingest more or fewer doses than recommended by the doctor. Otherwise, this can bring harmful effects on health.

If a dose is missed, the patient should take it as quickly as possible without joining two doses simultaneously; it is preferable to skip the forgotten one. To avoid this type of event, it is necessary to keep a check or look for alternatives such as reminder alarms and thus strictly follow the treatment.

The patient needs to monitor their blood pressure during treatment to determine the evolution or improvement of the condition. This is essential for the doctor because you can decrease or increase the dosage if necessary.


 Side effects

This medicine does not usually cause allergic reactions, but if the patient has the following symptoms, he should contact his doctor:

  • Swallowing problems
  • Chest pain.
  • Wheezing when breathing
  • Skin hives.
  • Difficulty breathing fluently.
  • Redness in the cheekbones of the face or chest.
  • Swelling in the throat, tongue, and lips.

The patient should contact his doctor if the following symptoms occur when starting treatment with Sacubitril:

  • Chronic tiredness
  • Feeling dizzy
  • Sudden fainting spells
  • Weak pulse
  • Renal problems.
  • Muscular weakness.
  • Slow heartbeat rate.

The most common side effects of these types of medications are:

  • Dry cough.
  • Dizziness

If the patient, when ingesting Sacubitril, presents the following adverse symptoms, he should contact his treating doctor or go to the nearest health center or hospital:

  • Blurred vision or difficulty focusing on objects.
  • Stomach or abdominal pain
  • Frequent dizziness or fainting.
  • Confusion.
  • Cardiac arrhythmia.
  • Trouble breathing normally.
  • Sudden nausea or vomiting.
  • Changes in mood
  • Cramp in the lips, hands, or feet.
  • Excessive sweating and without sports activities.
  • Unusual muscle weakness
  • Loss of appetite
  • Bleeding from the nose, mouth, stool, or urine.
  • Lumbar pain
  • Swelling in the hands or feet.
  • Fluid retention.
  • Hypotension


Women planning a pregnancy should inform their doctor before undergoing treatment with Sacubitril because this can cause counterproductive effects on the development of the unborn in the gestation process, even death.

If the patient is breastfeeding, she should inform her doctor because the components of this medicine can pass into breast milk and cause counterproductive effects on the baby.

Diabetic people cannot combine Sacubitril with aliskiren medicines because its combination can have harmful effects on health.

It is essential that the treating doctor knows the patient’s medical history; this will determine if the best option to treat his condition is Sacubitril, especially if he has suffered or suffers from:

  • Diabetes.
  • Some conditions in the liver.
  • Hereditary angioedema.

This medicine should not be combined with alcoholic beverages because it could decrease the effectiveness of the medicine and increase the chances of suffering from side effects.


Sacubitril should be stored in a place kept at room temperature, away from moisture and sunlight. It does not need to be refrigerated.

This medicine should be kept out of the reach of children and household pets; its use without a prescription can have counterproductive effects on the individual’s health.

If this happens, you should go to the nearest health center or hospital to receive the necessary help.