Renvela: Administration, Precautions, Side Effects, Warnings and Interactions

This medicine is a phosphate binder.

Phosphate primarily comprises the mineral phosphorus, an essential component of standard bone structure, cell metabolism, and cell function. The kidneys help keep the amount of phosphorus in the blood at a relatively constant level in the body.

For people with kidney problems, as their kidney function declines, less phosphorus is removed from the body, leading to a condition known as hyperphosphatemia  (high levels of phosphate in the blood).

High levels of phosphorus in the blood can cause problems with the strength and structure of the bones. This condition is known as renal osteodystrophy.

When taken with food, reveal prevents the absorption of phosphates from food by binding to phosphate. It is explicitly used to control high levels of phosphate (and therefore phosphorus) in the blood of people with severe kidney disease, known as end-stage renal disease, who are on dialysis.

What form (s) is this medicine in?

Each white, oval tablet imprinted with “RENVELA 800” contains 800 mg of anhydrous sevelamer carbonate.

  • Non-medicinal ingredients:  microcrystalline cellulose, sodium chloride, and zinc stearate.
  • Coating:  hypromellose and diacetylated monoglycerides.

How should you use this medicine?

The dose of reveal depends on the amount of phosphorus in the blood. The starting dose can range from 2.4 to 4.8 g per day. The daily doses of sevelamer carbonate are generally divided according to the food servings, where higher amounts of sevelamer carbonate are given with larger meals.


Your doctor may gradually increase the total daily dose of renvela according to the level of phosphorus in your blood. The tablets should be taken immediately before meals or with meals. Do not chew, chew, or separate the tablet before swallowing.

Do not change the dose without your doctor’s supervision or approval.

Who should NOT take this medicine?

Do not take reveal if:

  • You are allergic to tell or any of the ingredients in the medicine.
  • You have a bowel obstruction.
  • It has low levels of phosphorus in the body.

What side are effects possible with this drug?

Many of these side effects can be controlled, and some may go away on their own over time.

  • Headaches.
  • Heartburn or indigestion
  • Gases.
  • Constipation .
  • Diarrhea.
  • Nausea and vomiting
  • Itching and rashes.

If you have any of the following symptoms, you should see your doctor as soon as possible:

  • Abdominal pain.
  • Back pain or limb pain.
  • Difficulty in swallowing.
  • Fever.
  • Signs of inflammation in the digestive system (for example, pain in the lower left abdomen, fever, nausea, diarrhea, or constipation).
  • Upper respiratory tract infection (for example, bronchitis, sinusitis).

Stop taking medicine and seek immediate medical attention if any of the following symptoms occur:

  • Signs of an allergic reaction (shortness of breath or difficulty breathing, hives, swelling of the eyes, mouth, lips, or throat).
  • Signs of a blockage in the digestive system (abdominal cramps, gas pain, nausea, vomiting after meals, excessive belching).

Warnings about the use of the drug

You have to make sure, before taking medicine, that you are not allergic to any of its components. Also, discuss the use of reveal with your doctor if you have:

Gastrointestinal disorders

If you have gastrointestinal disorders (for example, dysphagia [difficulty swallowing], severe movement disorders in the gastrointestinal tract [i.e., esophagus, stomach, and intestine]), or if you have had major gastrointestinal surgery.

Consult with your doctor about how this medication may affect your medical condition, how your medical condition may affect the dosage and effectiveness of this medication, and if any special monitoring is needed.

Low calcium content

People with kidney disease can develop hypocalcemia (low levels of calcium in the blood). While taking this medicine, your doctor will regularly check your blood calcium levels.

If you experience signs or symptoms of low blood calcium levels, such as muscle cramps or pain, dry skin, or a tingling sensation in the fingers, lips, tongue, or feet, contact your doctor as soon as possible.


Discuss the possibility of taking this medicine with your doctor if you are pregnant or planning to become pregnant.


It is unknown if the drug passes into breast milk, so it is best to avoid taking the medication while breastfeeding. You can discuss this with your doctor.

Children and adolescents

How safe and effective the drug is for young people under 18 has not yet been established.

What other drugs could interact with this medicine?

There may be an interaction between reveal and any of the following drugs:

  • Calcitriol.
  • Levothyroxine.
  • Medicines for irregular heartbeat (antiarrhythmics, such as amiodarone and propafenone).
  • Mycophenolate.
  • Phosphate-containing medicines or products.
  • Quinolone antibiotics (for example, ciprofloxacin, norfloxacin, ofloxacin).
  • Anti-seizure medications (for example, carbamazepine and phenytoin).

If you are taking any of these medications, talk to your doctor or pharmacist.