Propinox: Mechanism of Action, Dosage, Contraindications, Side Effects, Interactions and Storage

Treatment of abdominal colic includes pain relievers such as non-steroidal anti-inflammatory drugs and antispasmodic agents.

Propinox is an antispasmodic drug frequently used to treat abdominal cramps and disorders of the gastrointestinal tract, uterus, and gallbladder. However, little is known about its relaxing activity in gallbladder tissue.

The term abdominal colic is used to describe spasmodic abdominal pain, which arises from enlargement, inflammation, or obstruction. It is often characterized as sharp, localized abdominal pain that increases, spikes, and subsides.

Although it is often a benign complaint, it can also signify more significant pathology. Therefore a careful medical history and physical examination are crucial to the approach to a differential diagnosis.

Mechanism of action of pro inox/pharmacokinetics

After administering a parenteral dose, the plasma half-life of lysine clonidine and pro inox is approximately 1 hour.

Lysine clonixinate is extensively metabolized, eliminating more than 60% of the administered dose in the urine, while pro inox is mainly excreted in the urine in unchanged form.

Propinox hydrochloride, also known as pargeverine hydrochloride, is an antispasmodic substance with a double mechanism of pharmacological action: musculotropic and anticholinergic.


Propinox also functions as a musculotropic agent, acting directly on visceral smooth muscle cells and conferring their antispasmodic activity. The anticholinergic (pro inox activity) is derived from a moderate and non-selective blockade of cholinergic muscarinic fibers.

Propinox dosage

This medication must be prescribed by a medical professional and follow the instructions for administration by the indicated one as they may vary from case to case.

Generally, these are the dosages established by the doctor:

Via Oral

  • For adults and children over 12 years: 20 drops, up to 5 times a day.
  • For children 1 to 12 years: 1 drop per year of age, up to 5 times a day.
  • For infants: 1 reduction, up to 5 times a day.

Intravenous or intramuscular use

For adults: 5 to 20 mg per day.

Propinox overdose

No cases of untreated overdose have yet been reported.

The signs and symptoms that could occur in case of overdose are the following:

  • Headache ( headache ).
  • Frequent nausea and vomiting.
  • Dilated pupils.
  • Hot and dry skin.
  • Dry mouth
  • Arrhythmias
  • Giddiness .
  • Confusion and symptoms of stimulation of the Central Nervous System.
Guiding initial treatment of overdose

After careful clinical evaluation of the patient, assessing the time elapsed since the administration, and ruling out the contraindication of specific procedures, neostigmine can be used subcutaneously or intravenously at 0.5 mg up to a maximum of 2 mg.

Severe arousal symptoms can be managed with sodium thiopental 2% in solution by slow intravenous route. General care measures, maintenance of the airway and oxygenation, and adequate monitoring of vital signs should always be carried out.

In the event of an overdose, go to the hospital center closest to your home.

There are no verifiable cases of pro-inox overdose; However, before the excessive consumption of propinox, you should immediately consult a doctor.

Contraindications of propinox

Propinox is contraindicated in the following cases:

  • Known allergy to propionate.
  • Known allergy to other NSAIDs.
  • Pyloric stenosis.
  • Digestive tract bleeding.
  • Peptic ulcer.
  • Clinical history of a bronchial spasm.
  • Prostatic hypertrophy.
  • Myasthenia serious.
  • Glaucoma.
  • Neuropathy.
  • Coronary heart disease.
  • Heart failure.
  • Arterial hypertension
  • Hepatic deficiency.
  • Pregnancy.

Possible side effects of pro inox

The following are side effects that may occasionally occur:

  • Dry throat and mouth.
  • Mydriasis .
  • Constipation.
  • Tachycardia.
  • Blurry vision.
  • Dysuria.
  • Confusion or excitability (this condition is seen regularly in geriatric patients).
  • Allergies
  • Dizziness
  • Drowsiness.
  • Increased intraocular pressure.
  • Cold sweat.
  • Loss of skin color.
  • Itching.
  • Violet eruptions on the skin.
  • Difficulty urinating.

Propinox interactions

The following are some interactions of this drug:

Anticholinergics (or have anticholinergic effects) such as atropine, homatropine, and pirenzepine.

Not all possible interactions of propinox appear in this list.


  • Grageas : propinoxate 5 mg.
  • Drops : propinoxate 5 mg (each ml).
  • Solution for injection : propinoxate 5 mg (each 1 ml ampoule).

Propinox storage

The pro inox must be protected from light, heat, and humidity as these factors can alter the medicine.

Keep out of reach of children.