Panadol: Indications, Mechanism of Action, Dosage, Side Effects, Warnings, Contraindications and Interactions

It is a medicine that contains a combination of ingredients to combat cold and flu symptoms.

Panadol belongs to a group of medicines called pain relievers and antipyretics ( fever reducers ).

It works quickly to relieve pain caused by conditions such as headaches and osteoarthritis and to reduce fever caused by infection.

Unlike acetylsalicylic acid, a pain reliever and antipyretic, panadol does not reduce inflammation.

Active ingredients of panadol

  • Acetaminofeno 500 mg.
  • Phenylephrine hydrochloride 5 mg.
  • Chloropheniramine Maleate 2 mg.
  • Dextromethorphan Hydrobromide 15 mg.


Panadol comes in many different formulations, such as tablets, soluble tablets, capsules, suppositories, etc.


Panadol is used for the quick, effective, and temporary relief of pain and discomfort associated with:

Mechanism of action of panadol

Panadol is a drug with analgesic (reduces pain) and antipyretic (reduces fever) but does not have anti-inflammatory activity.



In adults and children over 12 years: one to two tablets every four hours (maximum of eight tablets in 24 hours).

In children 7 to 12 years old: averaging one tablet every four hours (maximum of four tablets in 24 hours), taken with water or another liquid.

The soluble tablets must be dissolved in at least half a glass of water.

Panadol suppositories should be administered:

  • In children six months to 3 years: a 125 mg suppository.
  • In children 4 to 8 years: a suppository of 250 mg.
  • In children 9 to 12 years: one suppository of 500 mg
  • In adults: two suppositories of 500 mg.

Suppositories can be inserted up to 4 times in 24 hours if necessary. To facilitate insertion, the suppository can be moistened.

Side effects

The side effects of panadol are as follows:

  • Signs of anemia include a low level of red blood cells such as dizziness, pale skin, unusual tiredness or weakness, and shortness of breath.
  • Nausea.
  • Signs of clotting problems include unusual nosebleeds, bruising, blood in the urine, coughing up blood, bleeding gums, and cuts that won’t stop bleeding.
  • Signs of kidney problems include increased urination at night, decreased urine output, blood in the urine, and a change in urine color.
  • Signs of infection
  • Symptoms not present before treatment, such as sore throat, sores, ulcers or white spots on the lips or mouth, and fever with or without chills.
  • Skin rash, hives, or itching.
  • Symptoms of liver damage include abdominal pain, dark urine, itchy skin, pale stools, and yellow skin or eyes.

Stop taking medicine and seek immediate medical attention if any of the following occur:

  • Signs of a severe allergic reaction include labored breathing, hives, and swelling of the face or throat.
  • Symptoms of a serious skin reaction include high fever, rash, sores, or painful blisters on the skin, mouth, or eyes; or peeling skin).
  • Signs of overdose include diarrhea, increased sweating, nausea or vomiting, loss of appetite, stomach cramps or pain, bloating, pain, or tenderness in the upper abdomen or stomach area.

Warnings and Contraindications

Before using this product, the doctor should be informed about the medical history, especially about the patient’s allergies to this medicine or any other substance and the presence of liver disease, regular use, and abuse of alcohol.

Liquid products, chewable tablets, and dissolving or effervescent tablets may contain sugar or aspartame.

Caution is advised if you have diabetes, phenylketonuria, or any other condition requiring limiting and avoiding these substances in your diet.

The doctor should be informed if you are pregnant or if you are breastfeeding before using this medicine:

  • Pregnancy: Panadol is reported to be safe for short-term use in pregnancy at recommended doses.
  • Breastfeeding: Panadol passes into breast milk but is not likely to hurt the baby when used in recommended doses.

Panadol interactions

The following drug interactions as blood thinners such as warfarin and other medications such as isoniazid and ketoconazole have been reported.