Index
It is a centrally acting oral relaxant of the skeletal muscle that is used for the treatment of acute muscle pain.
Indications
Also for pain in general and for spasms. Likewise, and yet, the exact mechanism of action of this drug to relieve muscle aches or spasms has not been fully broken down into filigree.
In a separate case, however, this drug can very well reduce muscle spasms through actions in the motor centers or the marrow in the brain. This is why it is believed or thought that orphenadrine does not seem to have any direct relaxing effect on skeletal muscle.
It is structurally related to the antihistamine diphenhydramine (Benadryl), however, its main difference with this is that its antihistamine activity is lower than that of diphenhydramine.
But, also orphenadrine also has some local anesthetic effects.
As a curious fact, the FDA approved orphenadrine in 1959.
Available brands
Currently there is Norflex, which is currently discontinued in the United States, but not in other countries.
Orphenadrine is available as a generic drug?
The generic of this medicine is available in different parts of the globe.
Do I need a recipe?
Because it is a delicate consumer drug, yes, anyone who wants to acquire it must present a certificate prescribed by a doctor.
Side effects
Basically, the main side effects of orphenadrine can be summarized in the following:
- Increased heart rate
- Itch.
- Dizziness.
- Drowsiness.
- Headache.
- Confusion.
- Urinary retention.
- Constipation .
- Nausea.
- Vomiting
- Dry mouth.
- Dry eyes.
- Stomachache.
- Weakness.
- Nasal congestion.
Rare but serious side effects include aplastic anemia and life-threatening allergic reactions.
However, the person should bear in mind that this list may not be presented in its entirety in one person so that other side effects may occur that are ignored here and that in any case depend on whether the patient is in parallel pharmacological treatments.
Dose
The dosage of the medication can vary from doctor to doctor and according to the levels of trauma of the patient. However, the recommended dose is a 100 mg tablet taken orally twice a day in the morning and at night.
Interactions
Orphenadrine can cause an increase in blood levels of dofetilide (Tikosyn) by decreasing its decomposition and elimination by the liver.
Also, you should be very aware that orphenadrine may cause drowsiness. Taking orfenadrine with other medications that have similar CNS depressant effects may increase the CNS depressant effects of orphenadrine.
So it is recommended to be responsible with your intake and avoid as far as possible to manage your va or have taken a dose of the medication.
Similarly, this medication can cause anticholinergic side effects such as:
- Dry mouth.
- Dry eyes.
- Constipation.
- Confusion.
- Decrease in urinary frequency.
Taking medications that also have anticholinergic effects increases the effect of orphenadrine.
Is it safe to take orfenadrine if I am pregnant or nursing?
It is not known for sure if the medication orphenadrine is secreted in breast milk. However, precisely because of this ignorance, orphenadrine should be avoided during pregnancy if possible.
Presentations
- Orphenadrine citrate tablets: prolonged release of 100 mg.
- Solution for injection: 30 mg / ml.
What is the best mode of preservation?
Generally, it is recommended that tablets should be stored at room temperature, between 15 C and 30 C (59 F and 86 F).
Summary
Finally, it can be said that orphenadrine is a prescription medication used to treat muscle aches, pains or acute spasms.
Information on side effects, interactions with other medications, warnings, precautions, dosing, storage, pregnancy and breastfeeding are included.
And that, however, its mechanism of action within the human organism is unknown.
