Ophthalmic Chloramphenicol: What is it? Presentations, Considerations, Uses, Interactions, How to Use and Storage

It is a broad-spectrum bacteriostatic antibiotic that acts against gram-negative and gram-negative bacteria, as well as against other microorganisms.

Chloramphenicol belongs to the family of medicines called antibiotics. Ophthalmic preparations of Chloramphenicol are used to treat eye infections. This medicine can be given alone or with other medications taken by mouth for eye infections.

Chloramphenicol is available only with the prescription of a specialist.

Chloramphenicol Ophthalmic is available in the following presentations:

  • Solution
  • Ointment
  • Powder for solution

Considerations and uses


Tell your doctor if you have ever had a strange or allergic reaction to this medicine or any other medication. Also, tell your health care professional if you have many different types of allergies, such as foods, dyes, preservatives, or animals.

For non-prescription products, carefully read what ingredients it contains and check if any can affect your health.


Studies of this medicine have been conducted only in adult patients. There is no specific information sharing on the use of this medication in children with use in other age groups.


Many medications have not been studied explicitly in older adults. Therefore, it can not be known if they work the same way as they do in younger adults or if they cause different side effects or problems in older people.


There is no specific information that shares the use of this medication in old age with use in other age groups.


There are no adequate studies on women to determine the baby’s risk when using this medicine during breastfeeding. Weigh potential benefits against risks before taking this medication while breastfeeding is organized.


The mixture of this medicine with any of the following mentioned is not generally recommended but can be presented according to some specific treatment. If both medications are given, your doctor may change the dose or how often you use one or both drugs.

  • Citalopram
  • Voriconazole
  • Ceftazidime
  • Clorpropamida
  • Cyclosporine
  • Dicumarol
  • Fosfenitoin
  • Phenytoin
  • Rifampin
  • Rifapentine
  • Tacrolimus
  • Tetano toxoid
  • Tolbutamida

Other interactions

Certain medications should not be used when eating or eating some types of food, as interactions may occur. Using alcohol or tobacco with certain medicines can also cause interactions. Discuss the use of your medicine with food, alcohol, or smoking with your health professional.

Additional Information

Our own clinical experience in general practice over the past 15 years has indicated that ophthalmic drops of Chloramphenicol may have a favorable effect on many patients concerned with symptoms indicative of acute maxillary sinusitis. We wanted to conduct a pilot study to test if this observation could be verified.

Material and method

Treatment with Chloramphenicol ophthalmic drops or systemic peroral antibiotics was tested in patients with symptoms indicative of acute maxillary sinusitis. Patients were randomly assigned to two groups, one of which received systemic peroral antibiotics, and the other received eye drops with Chloramphenicol.


A total of 33 patients were included in the trial, 27 women and six men, 15 of whom were randomized to the group of tablets, and 18 of them were randomized to the Chloramphenicol group.

Patients who were treated with tablets experienced a clear improvement after an average of 5.0 days, while patients who were treated with florfenicol eye drops experienced edit after 3.7 days (p = 0.047).

Of the patients in the Chloramphenicol group, 14 described an improvement in three days, whereas this was applied to only five patients in the group of tablets.


Treatment with Chloramphenicol drops seems to represent a treatment option for some patients with symptoms indicative of acute maxillary sinusitis.

In the pilot study, the period of treatment before the symptoms improved was shorter in patients who received eye drops than in patients who received systemic peroral antibiotics.

These promising results provide the basis for carrying out studies on a larger scale. Even if the bottle is not complete, patients who use the drop eye form of Chloramphenicol contain precisely the amount of medication your doctor ordered.

How to use?

To use, first wash your hands. Tilt your head back and gently press your finger on the skin below the lower eyelid; remove the lower eyelid from the eye to make room. Drop the medicine in this space. Release the eyelid and gently close your eyes, and do not blink.

Keep your eyes closed and apply pressure to the inside corner of your eye with your finger for 1 or 2 minutes to allow the medicine to contact the infection. If you think you did not receive the medication drop in your eye correctly, use another drop.

To keep the medicine as germ-free as possible, do not touch the tip of the applicator or the dropper on any surface (including the eye). Also, keep the container tightly closed.

To use the ointment form for Chloramphenicol eyes first, wash your hands. Tilt your head back and gently press your finger on the skin below the lower eyelid, remove the lower eyelid from the eye to make room.

Squeeze a thin strip of the ointment in this space. Generally, a 1 cm ointment strip (approximately 1/3 inch) is sufficient unless your doctor tells you to use a different amount. Release the eyelid and gently close the eyes.

Keep your eyes closed for 1 or 2 minutes to allow the medication to come into contact with the infection. To keep the medication as germ-free as possible, do not touch the tip of the applicator with any surface (including the eye).

After using Chloramphenicol ophthalmic ointment, wipe the tip of the cream with a clean cloth and keep the tube tightly closed.

To help eliminate the infection, continue to use this medication throughout the treatment, even if your symptoms start to disappear.

After some days, if you stop using this medicine too soon, your symptoms may return. Do not miss any dose.

The dose of this medication will be different for different patients. Follow your doctor’s orders or the instructions on the label. The following information includes only the average doses of this medication.

If your dose is different, do not change it unless your doctor tells you to. The amount of medication you take depends on the potency of the drug.

In addition, the amount of dose you take each day, the time allowed between doses, and the time you take medicine depend on the medical problem for which you are using the medication.

For eye infections: for the dosage form of an ophthalmic ointment, use it every three hours for adults and children.

For the ophthalmic solution ( drops for the eyes ), pharmaceutical form: Adults and children: one drop every four hours.

The reduced dose if you miss a dose of this medicine, apply it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and return to your regular dosing schedule.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Avoid freezing. Keep out of reach of children. Do not stop using obsolete medications or medications.