Necroton: Presentation, Indications, Mechanism of Action, Dosage, Side Effects, Warnings, Contraindications and Interactions

It is a drug that is generally used in liver therapies.

Necroton is used in the treatment of mild liver dysfunction . It belongs to the group of medicines called lipotropics.

Necroton is an antinecrotic and antitoxic substance isolated from the liver, which has been widely used for the clinical treatment, in addition to liver disorders , for cases of poisoning due to the action of carbon tetrachloride.

Active ingredients

The active ingredients in necroton are orotic acid and oxypurine.


Necroton comes in various forms:

In capsules

Each necroton capsule contains 150 mg of orotic acid and 75 mg of oxypurine.

In suspension

Necroton in suspension is sold in 120 ml bottles, each 100 ml of suspension contains monohydrated orotic acid (2,224 g), oxypurines (0.050 g) and 20 g of sorbitol.

In injectable solution

Necroton in injectable solution is sold in ampoules, each ampoule contains 12.5 mg oxypurines and 12.5 mg orotic acid.

In concentrate

Necroton concentrate is marketed in a dual vial-vial, the vial with the solid fraction containing 30 mg of oxypurines and the vial with the liquid fraction, containing 30 mg of orotic acid.


Necroton is used in the treatment of hepatovesicular and pancreatic insufficiency.

He is a collaborator in the therapy of uncomplicated liver dysfunction problems.

Mechanism of action

Necroton has orotic acid as a component, which improves protein and enzyme synthesis by interfering with protein metabolism.

In pyrimidine nucleotide biosynthesis, orotic acid is an intermediate product.

Orotic acid improves protein synthesis in the liver, since it has several effects in the body on protein metabolism, in addition to participating in purine metabolism.

Another important function of orotic acid is to assist in the metabolism of vitamin B12 and folic acid.

Its use in liver problems is preventive.

Orotic acid is a very powerful antioxidant that helps detoxify the body.

Oxypurine, for its part, has another mechanism of action. This acts as a choleretic by increasing the excretion of bile, produces the contraction of the gallbladder and enhances the enzymatic effect of liver cells.


The administration is generally as follows:

In capsules, the administration of necroton is recommended in doses of 2 or more capsules per day according to the doctor’s judgment.

In suspension

  • For children 1 to 6 years of age: the administration of necroton in doses of 1 teaspoon of 5 ml, 2 times a day is recommended.
  • For children 6 to 12 years of age: the administration of necroton in doses of 3 teaspoons of 5 ml per day is recommended.
  • In adolescents and adults: the administration of necroton in a dose of 1 tablespoon of 10 ml 3 times a day is recommended.

In injectable

It is recommended to administer 5 ml per day or more according to the doctor’s judgment.

In concentrate

The administration of necroton is recommended in doses of 1 vial-ampoule per day or more according to the doctor’s judgment. Ampoules should be shaken and placed deep intramuscularly.

Side effects

No side effects have been reported with the administration of necroton.

Giving the product as injections by themselves may cause diarrhea and itching, and temporary pain at the injection site.

Warnings and Contraindications

Contraindications are hypersensitivity to its components. Necroton should not be administered if you have allergies to the active ingredients of the drug or any of its components and should be administered with caution if you have any type of allergies to other medications.

Necroton should not be administered if the patient has severe liver failure.

The doctor must be informed if you are pregnant, so that the doctor adjusts the doses, which will depend on the months of pregnancy that the patient has, she must be medicated otherwise you could affect the development of the gestation process, arriving even to lose the baby.

The doctor should be informed if you are breastfeeding or plan to breastfeed.


Drug interactions can change the way some drugs work or increase the risk of serious side effects. But so far no interactions of necroton with other medications have yet been reported.