It is a drug that is generally used in liver therapies.
Necroton is used in the treatment of mild liver dysfunction. It belongs to the group of medicines called lipotropic.
Necroton is an antinecrotic and antitoxic substance isolated from the liver, which has been widely used for clinical treatment and liver disorders for cases of poisoning due to the action of carbon tetrachloride.
The active ingredients in necroton are orotic acid and oxypurinol.
Necroton comes in various forms:
Each necroton capsule contains 150 mg of orotic acid and 75 mg of oxypurinol.
Necroton in suspension is sold in 120 ml bottles; every 100 ml of suspension contains monohydrated orotic acid (2,224 g), oxypurinol (0.050 g), and 20 g of sorbitol.
In injectable solution
Necroton in injectable solution is sold in ampoules, each ampoule contains 12.5 mg oxypurines and 12.5 mg orotic acid.
Necroton concentrate is marketed in a dual vial-vial. The vial with the solid fraction contains 30 mg of oxypurinol, and the vial with the liquid fraction contains 30 mg of orotic acid.
Necroton is used in the treatment of hepatolenticular and pancreatic insufficiency.
He is a collaborator in the therapy of uncomplicated liver dysfunction problems.
Mechanism of action
Necroton has orotic acid as a component, which improves protein and enzyme synthesis by interfering with protein metabolism.
In pyrimidine nucleotide biosynthesis, orotic acid is an intermediate product.
Orotic acid improves protein synthesis in the liver since it has several effects in the body on protein metabolism and participation in purine metabolism.
Another essential function of orotic acid is to assist in the metabolism of vitamin B12 and folic acid.
Its use in liver problems is preventive.
Orotic acid is a potent antioxidant that helps detoxify the body.
Oxypurine, for its part, has another mechanism of action. This acts as a choleretic by increasing the excretion of bile, producing gallbladder contraction, and enhancing the enzymatic effect of liver cells.
The administration is generally as follows:
In capsules, the administration of necroton is recommended in doses of 2 or more capsules per day according to the doctor’s judgment.
- For children 1 to 6 years of age: the administration of necroton in doses of 1 teaspoon of 5 ml, two times a day is recommended.
- For children 6 to 12 years of age: the administration of necroton in quantities of 3 teaspoons of 5 ml per day is recommended.
- In adolescents and adults, administering necroton in a dose of 1 tablespoon of 10 ml 3 times a day is recommended.
It is recommended to administer 5 ml per day or more according to the doctor’s judgment.
The administration of necroton is recommended in doses of 1 vial-ampoule per day or more according to the doctor’s judgment. Ampoules should be shaken and placed deep intramuscularly.
No side effects have been reported with the administration of necroton.
Giving the product as injections may cause diarrhea, itching, and temporary pain at the injection site.
Warnings and Contraindications
Contraindications are hypersensitivity to its components. Necroton should not be administered if you have allergies to the drug’s active ingredients or any of its members and should be administered with caution if you have any allergies to other medications.
Necroton should not be administered if the patient has severe liver failure.
The doctor must be informed if you are pregnant. The doctor adjusts the doses depending on the months of pregnancy that the patient has; she must be medicated; otherwise, you could affect the development of the gestation process, arriving even to lose the baby.
The doctor should be informed if you are breastfeeding or plan to breastfeed.
Drug interactions can change how some drugs work or increase the risk of severe side effects. But so far, no exchanges of necroton with other medications have yet been reported.