Mupirocin: Warnings, Dosage, Side Effects, Interactions and Considerations

It is a prescription medicine used to treat certain skin infections, such as impetigo and methicillin-resistant Staphylococcus aureus.

Mupirocin is an antibiotic that works by killing the bacteria or preventing their growth. It is sold under the Bactroban and Century brands.

The Food and Drug Administration (FDA) approved Mupirocin in 1987 for the manufacturer Glaxo Smith Kline with the Bactroban brand. The generic Mupirocin is now available in several pharmaceutical companies.

Mupirocin is used to treat impetigo and other superficial skin infections caused by certain types of bacteria. Mupirocin belongs to a group of medications called topical antibiotics, used directly on the skin to kill bacteria.

This medication comes as a skin cream and is usually used three times a day. It also comes in a nasal ointment and is generally used two times a day.

Common side effects of Mupirocin include itching, burning, and redness in the area where the medication is applied.


Do not use Mupirocin if you have a yeast or viral infection. This medicine is only effective against bacterial infections.


Before taking Mupirocin, tell your doctor if you have:

  • Allergies to any medication
  • Kidney problems
  • A burn or open wound.

Do not swallow Mupirocin or put the medication in your eyes.

Talk to your doctor before giving this medicine to a child.

Mupirocin can put you at risk of developing a severe form of diarrhea known as C or pseudomembranous colitis, which may occur during treatment several months later.

Call your doctor immediately if you have:

  • Severe diarrhea
  • Stools with blood.
  • Stomach pain or cramps.

Mupirocin is an antibiotic that treats skin infections. Do not apply bandages, cosmetics, lotions, or other skin medications to the area to be treated unless your doctor tells you to.

Do not use this medication for a shorter or longer period than prescribed by your doctor.

Mupirocin for more extended periods can cause a secondary infection. Stopping the medication too soon may not clear up your condition.

Call your doctor if you still have symptoms of an infection after you finish your treatment with Mupirocin or if your symptoms do not improve after three to five days of taking the medication.

Pregnancy and Mupirocin

This drug is not likely to cause harm to an unborn baby. However, tell your doctor if you are pregnant or plan to become pregnant before taking it.

It is not known if this medicine is found in breast milk or if it can harm a breastfeeding baby. Talk to your doctor before breastfeeding while using Mupirocin.

Side effects

Common side effects of Mupirocin:

Tell your doctor if any of the following side effects is severe or does not go away:

  • Burning, stinging, or pain in the affected area.
  • Itching or rash
  • Headache.
  • Mild nausea

Serious side effects of Mupirocin:

Tell your doctor immediately if you experience any of the symptoms listed in the Warnings section above or any of the following side effects:

Signs of an allergic reaction may include itching, rash or hives, swelling of the face, tongue, or throat, dizziness, or shortness of breath.

Also, burns or sharp or nasal burning through the nose (if you use the nasal formulation).

Serious side effects:

Serious side effects have been reported with Mupirocin. Tell your health care provider about any signs or symptoms of hypersensitivity, including the following:

  • Chest pain.
  • Swelling of the face, eyes, lips, tongue, arms, or legs.
  • Difficult breathing
  • Fainting.
  • Eruption.
  • Superinfection

Mupirocin should not be used for prolonged periods. Prolonged use can lead to the growth of dangerous organisms that are resistant or that do not respond to this medication.

Use Mupirocin for the duration prescribed by your doctor.

Do not take Mupirocin if you are allergic to it or any ingredients. Use caution when applying it to the face and avoid the eye area.

Trademarks of Mupirocina

It can be found in some way under the following brands:

  • Bactroban.
  • Century.
  • Muricin.

Interactions with other medications

No interactions with other medications have been identified. However, it would help inform your doctor about all your medicines, including prescription and over-the-counter medications, vitamins, and herbal supplements.

Not all drug interactions are known or reported, and new drug interactions are continually reported.

Interactions with food

Medications can interact with certain foods. In some cases, this can be harmful, and your doctor may advise you to avoid certain foods.

In the case of Mupirocin, there are no specific foods that you should exclude from your diet when you receive this medication.


Use Mupirocin precisely as prescribed by your doctor. Follow the instructions carefully on your prescription label.

The dose of Mupirocin that your doctor recommends will be based on the following:

  1. The condition that is being treated.
  2. How you respond to this medication

The recommended dose range for Mupirocin in children and adults varies according to the size of the skin infection.


  • Store Mupirocin at room temperature at 25 ° C (77 ° F). The temperature can vary between 15-30 ° C (59-86 ° F).
  • Keep this medicine out of the reach of children.