Index
This medicine increases movement through the digestive system. It is used to treat the symptoms of stomach disorders.
It can also prevent nausea and vomiting caused by certain medications.
Due to safety concerns, this drug should not be used by breastfeeding women to increase breast milk production.
What Motilium is used for
Motilium is used to treat the following conditions in adults:
Nausea and vomiting, discomfort caused by a slow-moving stomach known as gastroparesis.
Symptoms include not being able to finish a meal, feeling “too full” or bloated after a meal, loss of appetite, feeling sick and perhaps vomiting, or burping without relief.
Motilium is an antiemetic and prokinetic medicine.
It works by blocking the action of a chemical messenger in the brain that causes the sensation of nausea and vomiting, and it also increases movement or contractions of the stomach and intestines, allowing food to move more quickly through the stomach.
Your doctor may have prescribed Motilium for another reason.
How does it work?
This medicine works by blocking chemicals in the brain and intestine. This causes improved movements and faster gastric emptying that helps prevent vomiting.
Motilium tablets contain the active ingredient domperidone, a type of medicine called a dopamine antagonist. It works in two ways.
Domperidone works primarily by blocking dopamine receptors found at the upper end of the digestive system.
This causes tightening of the muscles at the entrance to the stomach, relaxation of the muscles at the exit of the stomach, and further contraction of the muscles in the stomach.
These actions speed up the passage of food through the stomach into the intestine, which helps prevent vomiting and reduces feelings of sickness, bloating, and fullness.
It also prevents food from flowing the wrong way through the stomach and thus prevents reflux (regurgitation of stomach contents back into the food chain).
Domperidone also blocks dopamine receptors in the brain, known as the chemoreceptor activating zone (CTZ).
The chemoreceptor trigger zone is activated by nerve messages from the stomach when an irritant is present.
It is also activated directly by agents that circulate in the blood, for example, chemotherapy drugs. Once activated, it sends messages to another area of the brain, the vomiting center, which sends messages to the gut, causing the vomiting reflex.
Blocking dopamine receptors in the chemoreceptor trigger zone prevents nausea messages from sending to the vomiting center. This reduces the feeling of nausea and prevents vomiting.
Motilium side effects
Headache, nervousness, flushing, or irritability may occur the first few days as your body adjusts to the medicine.
Also reported were trouble sleeping, stomach cramps, hot flashes, and leg cramps. Notify your doctor immediately if you have:
Chest pain, slow, fast or irregular heartbeat, swelling of the feet or ankles, difficulty urinating, swollen breasts or nipple discharge in men or women, menstrual changes, and sexual problems.
You may need medical treatment if you have any side effects. Tell your doctor if you experience any of the following:
Difficulty sleeping, depression, dizziness, tiredness. Drowsiness or drowsiness, fits or convulsions, agitation. Dry mouth or thirst
She was spitting up, diarrhea, constipation, nausea, changes in appetite, or heartburn. Rash or itchy skin. Itchy eyes and crusty eyelids with discharge. Mouth ulcers or cold sores.
These are mild side effects of Motilium. Irregular or no menstrual period. Unusual secretion of breast milk or decreased sex drive in men or women.
Breast tenderness or breast enlargement in men and women. See your doctor immediately if you notice any of the following, as you may need urgent medical attention:
Fast or irregular heartbeat Swelling of the hands, ankles, or feet. I am urinating more often or having painful urination.
Stop using Motilium and tell your doctor immediately if any of the following happens:
You have an allergic reaction to Motilium (the allergy can be recognized, for example, skin rash, itching, difficulty breathing, and swelling of the face, lips, mouth, tongue, or throat that may cause difficulty in swallowing or breathing).
Other side effects not mentioned above can also occur in some people. Contact your doctor or pharmacist if you notice other effects not listed above.
Notes: Laboratory tests may be performed periodically while taking this medication to monitor its effects and prevent side effects.
Motilium precautions
This medicine should be used only if necessary during pregnancy. Due to the potential risks to a nursing infant, breastfeeding is not recommended when using this medication. Do not take Motilium if:
You are allergic to Motilium or any of the ingredients. See the Product Description at the end of this brochure for a list of ingredients.
An increase in stomach or intestinal contractions, for example, if you have had bleeding, blockage, or puncture in the gastrointestinal tract. You have problems with your heart, including abnormal heartbeats.
You are taking another medicine that contains the active ingredient ketoconazole, voriconazole, itraconazole, and posaconazole, which is used to treat fungal infections.
You are taking another medicine containing the active ingredient ritonavir or saquinavir used to treat HIV. You are taking another medicine containing the active ingredient telaprevir, used to treat hepatitis C.
You are taking an antibiotic with the active ingredient erythromycin, clarithromycin, or telithromycin. Do not use Motilium if the original packaging is torn or shows signs of tampering.
Before taking Motilium
Before you start taking it, you should tell your doctor if:
You are pregnant or planning to become pregnant. You are breastfeeding or wish to breastfeed. You have a pre-existing heart condition. You have or have never had kidney disease.
You have or have never had breast cancer. Motilium should not be used in children. Your doctor will advise you whether or not you take Motilium or whether you need to adjust the dose or modify your treatment.
Are you safe with alcohol?
Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Is it forming a habit?
No habit formation trends were reported.
Use in pregnancy
This medication in pregnant women is not recommended unless the potential benefits outweigh the risks involved. The effect of this medicine on the fetus is not established, and therefore, it is recommended to consult a doctor before taking this medicine.
Use during lactation
Breastfeeding mothers do not recommend using this drug, as there is a risk of side effects on the baby. It is recommended to consult your doctors and consider the possible benefits and risks before consuming this medication.
Drug interactions with Motilium
Because this medication improves movement in the digestive tract, it can affect the absorption and action of other medicines.
Therefore, you must tell your doctor about any non-prescription or prescription medicines you may take, especially: monoamine oxidase inhibitors (MAOIs), e.g., furazolidone, phenelzine, selegiline, and tranylcypromine.
Do not start or stop any medicine without the approval of a doctor or pharmacist.
Taking other medications
Motilium is known to interact with a large number of medications. You are advised to report the use of any medicines, including supplements and herbs, to your doctor.
Do not take Motilium if you are taking medicines that slow down the breakdown (metabolism) of other drugs in the body and can also affect your heart rate, such as:
Ritonavir or saquinavir are medicines for HIV / AIDS. Telaprevir is medicine for hepatitis C.
In particular, tell your doctor or pharmacist if you are taking any of the following:
Medicines to treat fungal infections, such as ketoconazole, fluconazole, itraconazole, and voriconazole.
Anticholinergic medicines (medicines to treat allergy, asthma, incontinence, gastrointestinal cramps, muscle spasms, depression, and sleep disorders, such as dextromethorphan or diphenhydramine).
Dopamine agonists (used to treat Parkinson’s disease or digestive disorders). Medicines used to treat HIV infections, such as amprenavir, atazanavir, fosamprenavir, indinavir, nelfinavir, ritonavir, and saquinavir.
Medicines used to treat high blood pressure or chest pain, such as diltiazem and verapamil. An antidepressant is called nefazodone. Medications that neutralize or reduce the amount of stomach acid, such as antacids.
Do not take medications that neutralize stomach acid or medicines that reduce stomach acid production within 2 hours of taking Motilium.
This is because enough stomach acid is required to ensure that Motilium is adequately absorbed by the body.
These medicines can be affected by Motilium, or they can affect how Motilium works. Your doctor or pharmacist can tell you what to do if you take any of these medicines.
Disease interactions
This is not an exhaustive list of possible drug interactions. You should consult your doctor about all possible drug interactions you are taking.
Kidney disease: Motilium tablets should be used with caution if you suffer from kidney function problems. Appropriate dose adjustment and safety monitoring are advised, especially if the disturbance is severe.
Liver disease : Motilium tablets should be used with caution if you suffer from liver failure. Adequate dose adjustment and safety monitoring are advised, especially if the alteration is mild to moderate. For severe deterioration, the use of this drug is not recommended.
Intestinal disorders: Motilium tablets should be used with extreme caution in people with severe intestinal problems, such as internal bleeding, obstruction, or perforation of the stomach and intestine. The use of alternative medicine is recommended in such cases.
Effect on the heart: Motilium tablets can affect the functioning of the heart, especially in the elderly and people who have an operational conditions, such as rhythm disorders and congestive heart failure.
Electrolyte imbalance: Motilium tablets should be used with extreme caution if you experience an acute or prolonged electrolyte imbalance.
Prolactin imbalance: Motilium tablets can cause an imbalance in prolactin levels which leads to menstrual cycle disturbances in women. Long-term use of this medicine can also cause breast-like growth in men.
How to take Motilium
Follow all instructions given to you by your doctor or pharmacist carefully. If you do not understand the instructions on the box/bottle, seek help from your doctor or pharmacist.
Do not increase your dose or take it more often than directed. Your condition will not improve any faster, but the risk of side effects will increase.
Take this medication by mouth as prescribed, usually 30 minutes before meals and bed.
How much to take
Adults: the usual dose of Motilium in adults is one tablet that can be taken up to three times a day. For nausea and vomiting, this drug is generally used for a maximum of 1 week; it should not be taken for more than a week at a time.
The prescribed dose depends on the symptoms being treated and varies from person to person. Always follow the instructions given by your doctor. These will be printed on the dispensing label that your pharmacist has put on the medicine package. Do not exceed the prescribed dose.
The Motilium tablet should be used for the shortest possible time. The dose should be kept as low as possible. Self-administration is not advised for these reasons.
For the other conditions, the initial duration of treatment is up to a maximum of 4 weeks. If you do not understand the instructions provided with this medicine, seek help from your doctor or pharmacist.
Pediatric Use: Motilium tablets should not be used in underweight or malnourished children. It should not be used in children weighing less than 35 kg.
Use in the elderly: Motilium tablets should be used with caution in the elderly as the risk of adverse effects is very high.
Motilium tablets should be swallowed with a drink of water. Motilium tablets are recommended before meals as they may take longer to work if taken after meals.
Start of action
The maximum effect of this medicine can be seen within 30 to 60 minutes of administration.
Duration of effect
The effect of this medicine lasts up to 6 hours.
Motilium overdose
Symptoms of an overdose may include drowsiness, dizziness, confusion, twitching, muscle stiffness, and an irregular heartbeat.
Missed dose or if you forget to take it
Try to take each dose at the scheduled time. If you have trouble remembering to take your medicine, ask your pharmacist for some suggestions.
If you miss a dose, take it as soon as you remember; do not take it if it is almost time for the next dose; instead, skip the missed dose and resume your regular dosing schedule. Do not double the amount to catch up.
If you take too much Motilium, you may experience agitation, seizures, drowsiness, confusion, and uncontrollable movements such as irregular eye movements or an abnormal posture such as a crooked neck.
While using Motilium
The use of Motilium has been associated with a risk of unusual heartbeat or sudden heart failure.
Motilium should be used with caution and taken at the lowest effective dose, especially in older patients. Talk to your doctor if you have a pre-existing heart condition.
Motilium treatment should be discontinued if signs or symptoms appear that may be associated with unusual heartbeats.
Things you should do
Always follow your doctor’s instructions carefully.
Things you should not do
Do not drive or use machinery or participate in other activities that require mental alertness or coordination until you know how this medication affects you.
Do not use Motilium to treat any other complaint unless directed by your doctor. Do not give this medicine to anyone else, even if their symptoms seem similar to yours.
Product description
Motilium tablets are white film-coated round tablets. Each tablet is marked “M / 10” on one side and “JANSSEN” on the reverse. They are available in a cardboard blister of 25 or 100 tablets.
Ingredients
Each Motilium tablet contains 10 mg of domperidone as the active ingredient.
Lactose, cornstarch, microcrystalline cellulose, pregelatinized potato starch, povidone, magnesium stearate, hydrogenated cottonseed oil, sodium lauryl sulfate, and hypromellose.
Substitutes
Below is the list of drugs, which have the same composition, strength, and shape as Motilium M 10 MG Tablet, and, therefore can be used as its substitute:
- Bombax in 10 MG tablets from Ranbaxy Laboratories Ltd.
- Domel-Mt 10 MG tablet from Intas Laboratories Ltd.
- Domperidone 10 MG Tablets from Cadila Pharmaceuticals Ltd.
- Company 10mg Tablets by Zydus Cadila
- Tableta Mahadom 10 MG de Mankind Pharmaceuticals Ltd.
