Methylprednisolone: ​​Uses, Mechanism of Action, Side Effects and Interactions

Synthetic steroid of the glucocorticoid group is used in medicine for immunosuppressive and anti-inflammatory properties.

The oral methylprednisolone tablet is a prescription drug available as the Medrol brand drug.

It is also available as a generic medicine. Generic drugs usually cost less. In some cases, they may not be available in all strengths or forms, such as the brand version.

Methylprednisolone also comes in the form of a suspension or solution. A health care provider delivers these forms.

For what do you use it

This medicine is used to treat many conditions. It helps control inflammation and modify the immune response of your body. The conditions used to treat include:

  • Endocrine disorders, such as primary or secondary adrenocortical insufficiency.
  • Rheumatic disorders such as rheumatoid arthritis or psoriatic arthritis.
  • Collagen diseases such as lupus or systemic dermatomyositis.
  • Skin diseases such as psoriasis or Stevens-Johnson syndrome.
  • Severe allergies that were not controlled by another treatment, such as seasonal or year-round allergies or allergic reactions to medications.
  • Eye problems such as swelling or ulcers (ulcers) in the eye.
  • Stomach or intestinal problems such as ulcerative colitis or Crohn’s disease.
  • Other treatments do not control respiratory problems such as lung damage caused by beryllium poisoning or Loeffler syndrome.
  • Blood disorders such as low levels of platelets in adults or lack of red blood cells in children.
  • Neoplastic diseases such as blood cancer or cancer in the lymphatic system in adults.
  • Multiple sclerosis outbreaks.
  • Infections, such as trichinosis with brain or heart problems.

Mechanism of action

Methylprednisolone belongs to a class of medications called glucocorticoids. A type of medication is a group of medicines that work similarly. These medications are often used to treat similar conditions.

Methylprednisolone works by decreasing inflammation and changing your body’s immune response. This reduces the inflammation caused by your condition.


Side effects of methylprednisolone

The oral methylprednisolone tablet does not cause drowsiness, but it can cause changes in the function of your liver. These small changes can usually be reversed after stopping treatment with this medication. It can also cause other side effects.

The most common side effects of methylprednisolone may include:

  • Headache.
  • Nausea and vomiting.
  • Weight gain.
  • Confusion, emotion, and restlessness.
  • Swelling of the ankles, feet, or hands.
  • Skin problems, such as acne, thin skin, and shiny skin.
  • Increased thirst.
  • Infection.
  • High blood pressure
  • Muscular weakness.
  • Depression .

If these effects are mild, they may disappear in a few days or a couple of weeks. If they are more severe or do not go away, talk to your doctor or pharmacist.

Serious side effects:

Call your doctor if you have serious side effects, if your symptoms seem life-threatening, or if you think you have a medical emergency. Serious side effects and their symptoms may include the following:

Allergic reactions. Symptoms may include:

  • Acne.
  • Itching or hives.
  • Swelling of your face, lips, or tongue.

Changes in your emotions and mood. Symptoms may include:

  • Chronic depression
  • Anxiety.
  • Intense emotion or happiness
  • Changes of personality
  • Psychosis.

Eye problems Symptoms may include:

  • Changes in your vision
  • Eye pain.
  • Bulging eyes.

Diabetes. Symptoms may include:

  • Increased thirst.
  • Urinate more often than usual.
  • Pain in the hips, back, ribs, shoulders, arms, or legs.


Symptoms may include:

  • Fever.
  • Sore throat.
  • Sneeze.
  • Tos.
  • Swelling of the ankles, feet, or hands.
  • Wounds that do not heal.

Low levels of potassium in your blood. Symptoms include:

  • Weakness.
  • Irregular heart rhythm.

Hormonal changes. Symptoms may include:

  • Loss of appetite
  • Lack of energy.
  • Nausea.
  • Vomiting
  • Headache.
  • Fever.
  • Pain in the joints or muscles.
  • Irritation of the skin.
  • Weightloss.
  • Low blood pressure (may make you feel dizzy or faint).


The oral methylprednisolone tablet may interact with other medications, vitamins, or herbs you may be taking. An interaction is when a substance changes the way a medication works. This can be harmful or prevent the drug from working well.

To help avoid interactions, your doctor should handle all your medications carefully. Tell your doctor about all the medicines, vitamins, or herbs you take. Talk to your doctor or pharmacist to determine how this medication might interact with something else you are taking.

Medications that should not be used with methylprednisolone:

Do not take these medications with methylprednisolone. When used with methylprednisolone, they can cause dangerous effects on the body. Examples of these medications include:

  • Live vaccines, such as the vaccine against nasal flu.
  • The varicella vaccine.
  • The vaccine against measles, mumps, and rubella (MMR).

Do not receive a live vaccine while taking this medication. A live vaccine is a weakened version of a disease. The vaccine will not completely protect you from the disease while taking methylprednisolone.