Methergin: Uses, Side Effects, Substitutes, Precautions and Interactions

Semisintentile Methylergometrine is derived from the natural threshold alkaloid ergometrine. It is a powerful uterotonic agent.

To prevent postpartum hemorrhage and additionally increase uterine contractions. Doctors can prescribe Methergin; this belongs to the class of oxytocins.

It acts on the smooth muscle of the uterus and increases the basal tone, frequency, and amplitude of rhythmic contractions. It contains methyl ergometrine maleate as an active ingredient.

It can also be used for purposes not mentioned in this medication guide.


It is used in the treatment, control, prevention and improvement of the following diseases, conditions and symptoms:

  • Prevention and control of postpartum hemorrhage.
  • Increase uterine contractions.

Keep in mind that this medication may be available in several strengths for each active ingredient mentioned above.

The effect of the medication may be altered due to specific health problems you have or medications you are currently taking. Therefore, it is imperative to provide your doctor with a medical history. Also, let him know if you are allergic to certain foods or drugs.


Women who are pregnant or trying to conceive should inform their doctor before taking Methergine. This is because Methergine is a category C drug and is known to have harmful effects on the fetus.

Nursing mothers should also discuss the pros and cons of using Methergin with their doctor before taking it.

The medication dosage generally depends on several factors, such as the severity of the medical condition being treated, the patient’s medical status, age, weight, and sex.

The medication is available as a tablet or can also be taken as an injection.

Side effects

In addition to the desired effect, it can also cause some unwanted effects. In such cases, you should seek medical attention immediately.

This is not an exhaustive list of side effects. Tell your doctor if you experience any adverse reaction to the medicine:

  • Headache.
  • Incrise of cardiac frecuency.
  • He retched.
  • Nausea.
  • Slow heart rhythm

Is it safe with alcohol?

The interaction with alcohol is unknown. Please consult your doctor.

Is there any warning of pregnancy?

It may not be safe to use during pregnancy.

Is there any warning about breastfeeding?

It is probably safe to use during breastfeeding. Please consult your doctor.

Does this affect kidney function?

Caution should be exercised in patients with renal insufficiency.


Below is the list of medications that have the same composition, strength, and form as Methergin and can therefore be used as their substitute:

  • Tableta Ergolin 0.125mg.
  • Tableta Meline 0.125mg.
  • Uterine 0.125mg tablets.
  • Megastar 0.125mg Tablet.
  • Metharmed 0.125mg tablets.
  • Tablet Metergo 0.125Mg.
  • Mergox tablet.
  • Motrin tablet 0.125Mg.
  • Rekvina Laboratories Ltd.
  • Tablet Memcad 0.125Mg.
  • Ergogem 0.125mg tablet.
  • Tablet Wergomet 0.125Mg.
  • Engaging Tablet 0.125Mg.
  • Tableta Margin 0.125Mg.
  • Tableta Methercip 0.125Mg.
  • Methylergometrine 0.125Mg tableta.
  • Methargo Tablet.

Is there any omission instruction omitted?

If you miss a dose of Methylergometrine, take it as soon as possible.

However, if it is almost time for your next dose, skip the missed dose and return to your usual schedule. Do not double the amount.


Before using Methergin Tablet, tell your doctor about your current list of medications and take the following precautions:

  • Over-the-counter products (e.g., vitamins, herbal supplements, etc.)
  • Allergies
  • Existing diseases and current health conditions (pregnancy, upcoming surgery, etc.).
  • Some health conditions may make you more susceptible to the side effects of the medication.
  • Take as directed by your doctor or follow the address printed on the product leaflet.
  • The dose is based on your condition.
  • Do not drive or operate machinery.


Methergine tablets may interact with the following medications and products:

  • Eletriptan.
  • Ergotamine.
  • Itraconazole
  • Propranolol.
  • Rifampin.


Hypersensitivity to Methergin Tablet is a contraindication.

In addition, Methergine Tablet should not be used if you have the following conditions:

  • High blood pressure.
  • Hypersensitivity
  • Pregnancy.