Medroxyprogesterone: Indications, Available Brands, Presentations, Administration and Interactions

This medication is usually used to regulate irregular menstrual cycles in women during the procreation period.

Medroxyprogesterone belongs to the class of medications called progestins. Progesterone is a female hormone.

In this way, the medroxyprogesterone can significantly reduce the effects of estrogen on tissues such as the endometrium and the mother.


Medroxyprogesterone has different uses:

In addition to Estrogen Replacement Therapy (ETS), it is used to:

  • Avoid the deposition of estrogen in the lining of the uterus.
  • Significantly reduce the risk of endometriosis failure.
  • It is also prescribed for irregular menstrual cycles.
  • It is applied in menstrual periods and abnormal or irregular menstrual bleeding.
  • Medroxyprogesterone is also used alone or with other anti-cancer drugs to treat endometrial and breast cancer.

Available Brands

Unlike other medicines whose patent is in the hands of one or very few laboratories, in the case of medroxyprogesterone, it is available under several brands or different presentations.

A unique brand of this medication may be available in all forms. In addition, some forms of this medication can not be used against all the conditions mentioned in this article.


The doctor may have suggested this medication to treat a condition not listed in this medication information article. Do not stop taking this medication without first consulting a doctor.


2.5 mg:

Each tablet, pink-orange, biconvex, marked with the inscription “MED” to “2,5” on both sides, Contains 2.5 mg medroxyprogesterone acetate. Inactive ingredients:

  • Lactose monohydrate.
  • Microcrystalline cellulose.
  • Croscarmellose sodium.
  • Magnesium stearate.
  • Sulfato de laurel de sodio a dioxide colloidal silica, FD & C Yellow # 10 se FD & C Yellow # 6.

5 mg:

Each round tablet, blue, biconvex, printed with “MED” to “5” on one side, contains 5 mg of medroxyprogesterone acetate. Inactive ingredients:

  • Lactose monohydrate.
  • Microcrystalline cellulose.
  • Croscarmellose sodium.
  • Magnesium stearate.
  • Sodium lauryl sulfate.
  • Colloidal silicon dioxide are FD & C Blue # 2.


The consumption of medroxyprogesterone should be about medical prescription. The doses to be taken can not be random or, say, standardized but, on the contrary, personalized to each person depending on their condition and the ultimate purposes given to the medication about the patient’s condition.

Thus, for example, the recommended dose of medroxyprogesterone for adults is widely designed for the condition being treated and the response to work.

The dose ranges from 2.5 mg per day to 10 mg per day for hormone replacement therapy for several specific days of the month.

For the treatment of abnormal menstruation, a typical dose of medroxyprogesterone is 5 to 10 mg per day for ten days.

A typical dose for breast cancer treatment is 400 mg per day.

For the treatment of endometrial cancer, the dose is 200 mg to 400 mg per day.

Several factors can be considered to determine the dose a person needs: weight, health, and other medications. If the doctor recommends a different amount than those listed here, do not change how you take the drug without first consulting it.

Unless medroxyprogesterone is part of the treatment for breast cancer, it should not be taken by women whose uterus is not intact.

Endometrial hyperplasia is treated for 12 to 14 consecutive days commencing on day 1 or 16 of the menstrual cycle.

The dose for contraception is 150 mg every three months injected intramuscularly or 104 mg injected subcutaneously every three months.

The dose for endometrial or renal cancer is 400-1000 mg weekly.


Aminoglutethimide (Cytadren) may increase the elimination of medroxyprogesterone by the liver, which leads to a decrease in the concentration of medroxyprogesterone in the blood and, possibly, a reduction in the efficacy of medroxyprogesterone.