Madecassol: Uses, Composition, Side Effects, Precautions and How to Use

It contains Centella Asiatica Extract as an active ingredient, used as an ointment, decreasing inflammation and blood pressure in the veins.

Madecassol is used for minor injuries and other conditions. It can also be used for purposes not mentioned in this medication guide.


It is used in the treatment, control, prevention, and improvement of the following diseases, conditions, and symptoms:

  • Minor injuries
  • Psoriasis.
  • Varicose veins
  • Chronic venous insufficiency.

Composition and active ingredients

  • Centella Asiatica Exract

Keep in mind that this medication may be available in several strengths for each active ingredient mentioned above.

Side effects

The following is a list of possible side effects from all ingredients that make up Madecassol.

These side effects are possible, but they do not always occur. Some of the side effects can be rare but serious.

Consult your doctor if you notice any of the following side effects, especially if they do not go away:


  • Skin allergy
  • Headache.
  • Stomach ache.
  • Sickness.
  • Dizziness
  • Drowsiness.

It can also cause side effects not mentioned here. If you notice other side effects not mentioned above, contact your doctor for medical advice.

You can also report side effects to your local food and drug administration authority.


Before using Madecassol, inform your doctor about your current list of medications:

  • Over-the-counter products (e.g., vitamins, herbal supplements, etc.)
  • Allergies
  • Pre-existing diseases.
  • Existing health conditions (for example, pregnancy, upcoming surgery, etc.).

Some health conditions may make you more susceptible to the side effects of the medication.

How to use

Take as directed by your doctor or follow the address printed on the product packaging. The dose is based on your condition. Tell your doctor if your condition persists or worsens.

The essential points of advice are listed below:

  1. Could you not take it by mouth? Consult your doctor before using this medicine on open wounds, dry, chapped, irritated, or sunburned skin.
  2. Please wash your hands before and after applying it. Clean and dry the area of ​​the skin to be treated.
  3. Do not wash the treated area after applying Madecassol immediately. Also, avoid using other products in the treated area unless directed by your doctor.
  4. Applying an excessive amount can result in pilling. Use a thinner coat or a lesser amount of medication to prevent the formation of pellets.
  5. Avoid getting this medication in your eyes, nose, or mouth.

Data of interest

A study evaluated how the compound made Cassel (madecassic acid with neomycin sulfate and hydrocortisone acetate) on wound healing.

Madecassol is an extract titled Centella Asiatica, and its clinical effects are highlighted by the improvement of wound healing and the prevention and relief of excessive scar formation.

Neomycin sulfate has an antibiotic effect, and hydrocortisone acetate has anti-inflammatory and anti-allergic effects.

Therefore, the Madecassol compound has a synergistic effect with Madecasol Neomycin Sulfate and Hydrocortisone Acetate.

The experts compared the effect of the Madecassol compound on wound healing in the postoperative days.

This study examined the histological findings and gross findings that were the size of the wound, the epithelialization, and the quality of the granulation tissue.

Therefore, Madecasol showed a lower degree of inflammatory infiltration, shorter inflammatory phases, and less wound contraction.

In conclusion, the Madecassol compound can reduce the wound’s excessive contraction and promote healing.