Lincomycin: Administration, Side Effects, Warnings, Precautions and Mechanism of Action

It is indicated for the treatment of severe infections caused by gram-positive aerobic bacteria, including streptococci, staphylococci, and pneumococci.


The dosage of lincomycin depends on age:


The recommended dose is a 600 mg intramuscular injection, which is equivalent to 2 mL every 24 hours.

For more serious infections, 600 mg, equivalent to 2 mL, every 12 hours, or more frequently, depending on the severity of the infection, may be recommended.

It can also be administered into the vein, a dose of 600mg to 1g every 8 or 12 hours. In more serious infections, these doses can be increased.

In life-threatening infections, doses of up to 8g daily have been administered.

Children older than 1 month of age

The recommended dose is 10 mg / kg, intramuscularly, every 24 hours.

In more serious infections, it is recommended to administer 10 mg / kg every 12 hours or more often.

It can also be given intravenously, 10 to 20 mg / kg / day, at 8 to 12 hour intervals, depending on the severity of the infection.

In beta-hemolytic streptococcal infections, treatment should continue for at least 10 days, to decrease the possibility of rheumatic fever or posterior glomerulonephritis.

When lincomycin hydrochloride is administered in patients with severe renal impairment, the appropriate dose is 25% to 30% of that recommended for patients with normal renal function .

The lincomycin dose should be carefully determined in patients with severe renal or hepatic dysfunction, and serum lincomycin levels should be monitored during high-dose treatment.

Side effects

Tell your doctors right away if you have any of these serious side effects:

  • Watery or bloody diarrhea.
  • Urinating less than normal or not at all.
  • Fever, chills, body aches, flu symptoms.
  • Severe rash with blisters, peeling, and red rash.
  • Feeling like you might pass out.
  • Easy bruising or bleeding, unusual weakness.
  • White patches or sores inside your mouth or on your lips.

Less serious side effects include:

  • Nausea and vomiting
  • Swollen tongue
  • Vaginal itching or discharge.
  • Mild itching or rash.
  • Dizziness, spinning sensation.

When should I not use it?

This medicine should not be used by people who are hypersensitive to lincomycin or clindamycin.

The doctor should be warned if liver or kidney diseases, bronchial asthma, allergic conditions, or other pathologies appear, and also if the person is taking other medications.

Lincomycin hydrochloride should not be used to treat mild bacterial or viral infections.

This medicine should not be used by pregnant or breastfeeding women.

Warnings and cautions

Pseudomembranous colitis, which can progress from mild to fatal, has been reported with the use of many antibiotics, including lincomycin. Therefore, it is important to consider the diagnosis in patients who develop diarrhea subsequent to the administration of antibiotics.

Previous sensitivity to this drug and other allergens should be carefully investigated.

Colitis associated with antibiotic therapy and diarrhea occur more frequently, and can be more severe, in elderly and / or debilitated patients.

When treated with lincomycin, these patients should be carefully monitored for changes in bowel frequency.

Injectable forms of this product contain benzyl alcohol, which is associated with fatal gas syndrome in premature infants.

Lincomycin hydrochloride should be used with caution in patients with a history of gastrointestinal disease, mainly colitis, and people with a history of bronchial asthma or significant allergy.

Lincomycin hydrochloride should not be used in the treatment of meningitis, as it does not adequately penetrate the cerebrospinal fluid.

Lincomycin hydrochloride is not recommended for use in newborns.

During prolonged therapy, it is recommended to monitor kidney, liver and blood functions.

In the case of administration by infusion, lincomycin hydrochloride should not be administered as a bolus, but slowly.

Mechanism of action

Lincomycin hydrochloride is an antibiotic agent of the class of Lincosamides.

This substance inhibits protein synthesis in sensitive bacteria by binding to bacterial ribosomes.

Inhibition of protein synthesis leads to the death of bacteria.

Forms of medication

Lincomycin is available in the following forms:

  • Injectable solution.
  • Oral capsule.
  • Oral solution.


Lincomycin can be found in some form under the following brand names:

  • Bactramicina.
  • L-Mycin.
  • Linco-Jec.
  • Lincocin.
  • Lincomed.
  • Lincomix.
  • Lincorex.