Lansoprazole: What is it? Uses, Side Effects, Warnings and Interactions

Prevents and treats stomach and intestinal ulcers, esophagitis and other conditions of the stomach that involve excess acid production, such as zollinger-ellison syndrome.

Lansoprazole belongs to a class of medications called inhibitors that decrease the production of acid in the stomach. It effectively controls the pH of stomach secretions and acts as an alternative to intravenous pantoprazole in those who can not swallow solid dose formulations.

It is also used to treat frequent heart burns that occur 2 or more times a week.

Side effects

Some side effects of taking Lansoprazole include nausea, stomach pain, diarrhea, constipation and headache.

Stop the medication and consult your doctor immediately if you experience any serious side effects such as seizures, kidney problems or symptoms of low magnesium content in the body.

Tell your doctor if you have the following conditions before taking the medicine:

  • Liver disease
  • Low level of magnesium in the blood.
  • Low bone mineral density.
  • Problems swallowing
  • Stools or vomiting with blood or black.
  • Unexplained weight loss
  • Metabolic disorder
  • If you are pregnant or breast-feeding a baby.

Without a prescription Lansoprazole should not be administered to people over 18 years of age. The recommended initial dose is 30 mg, taken orally once a day for 8 weeks.

The maintenance dose for Lansoprazole is 15 mg, once a day. The dose may vary from person to person depending on your medical condition.


Helicobacter pylori infection

Lansoprazole is used to treat Helicobacter pylori infection in combination with other medicines.

Erosive esofagitis

Lansoprazole is used in the treatment of severe ulcers caused by chronic heartburn.

Multiple endocrine adenomas

Lansoprazole is used to relieve symptoms caused by a tumor in the endocrine system that affects the stomach and intestine.

Systemic mast cell disease

Lansoprazole is also used to relieve the symptoms of a condition in which the mast cells are abnormally high at certain specific sites in the stomach, intestine, and other parts of the body.

Other forms of ulcers

Lansoprazole is also used to prevent and treat ulcers in the stomach (gastric) and small intestine (duodenal) caused by medications for stress or pain.

In addition to the desired effect, Lansoprazole can also cause some unwanted effects. In such cases, you should seek medical attention immediately. This is not an exhaustive list of side effects. Tell your doctor if you experience any adverse reaction to the medicine:

  • Diarrhea.
  • Allergic reaction of the skin.
  • Severe stomach acne
  • Nausea and vomiting.
  • Symptoms similar to the flu.
  • Muscle or joint pain.
  • Depression.
  • Unusual bleeding
  • Headache.
  • Flatulence.
  • Inflammation of the face, lips, eyelids, tongue, hands and feet.
  • Irregular heartbeat.
  • Decreased appetite.

How long can the effect be prolonged?

The effect of this medication lasts an average duration of 24 hours.

What is the beginning of the action?

The effect of this medication can be observed in 1-3 hours after oral administration.

Is there any warning of pregnancy?

Pregnant women can use this medication only when necessary and the potential benefits outweigh the risks involved.

Consult your doctor before taking this medicine.

Is there any warning when breastfeeding?

Women who breastfeed do not recommend the use of this medication, as it may cause harm to the baby. However, if it is absolutely necessary to use this medication, then breast-feeding should be stopped.

Consult your doctor before taking this medicine.

Interaction with the disease

Liver disease

Report any incidence of liver disease to the doctor. Adequate adjustment of the dose may be necessary depending on the degree of liver failure.


An appropriate adjustment should be made in the dosage and duration of patients who are at risk of fracture related to osteoporosis. The established treatment guidelines must be followed strictly in such cases.


Report any incidence of imbalance of magnesium level in the body to the doctor. The imbalance can occur due to illness or due to other medications used by the patient.

Regular monitoring is patched for patients taking Lansoprazole in such cases. Interaction with alcohol Alcohol Interaction with alcohol is unknown. It is advisable to consult your doctor before consuming it.

Interaction with Medicines

Clopidogrel: Report the use of any of the medications to the doctor. Your doctor may prescribe a safer alternative to reduce your heartburn while you are being treated with Clopidogrel.

Ketoconazole: This medicine should be used with Ketoconazole or other antifungals from the same group with caution. Tell your doctor about the use of any of these medications so that you can prescribe safer alternatives.

Methotrexate :  The use of any of the medications should be reported to the doctor so that a safer substitute may be prescribed.

Warfarin: The use of Lansoprazole with warfarin should be monitored strictly by the doctor. Proper adjustment in dosing and control of Prothrombin time is necessary to ensure safety.

Any symptoms such as unusual bleeding, swelling, vomiting, presence of blood in the urine should be reported immediately.

Nelfinavir: This medication is not recommended for use when the patient is already taking antiviral medications such as Nelfinavir or other drugs used in the treatment of HIV infection.

Digoxin:  The prior use of any of these medications should be reported to the doctor. Any symptoms such as nausea, vomiting, diarrhea, loss of appetite, visual disturbances and abnormalities in the heartbeat should be reported immediately.