Lansoprazole: What is it? Uses, Side Effects, Warnings and Interactions

Prevents and treats stomach and intestinal ulcers, esophagitis, and other conditions of the stomach that involve excess acid production, such as Zollinger-Ellison syndrome.

Lansoprazole belongs to a class of medications called inhibitors that decrease acid production in the stomach. It effectively controls the pH of stomach secretions and acts as an alternative to intravenous pantoprazole in those who can not swallow solid dose formulations.

It is also used to treat frequent heartburns that occur twice a week.

Side effects

Some side effects of taking Lansoprazole include nausea, stomach pain, diarrhea, constipation, and headache.

Stop the medication and consult your doctor immediately if you experience any severe side effects such as seizures, kidney problems, or symptoms of low magnesium content in the body.

Tell your doctor if you have the following conditions before taking medicine:

  • Liver disease
  • Low level of magnesium in the blood.
  • Low bone mineral density.
  • Problems swallowing
  • Stools or vomiting with blood or black.
  • Unexplained weight loss
  • Metabolic disorder
  • If you are pregnant or breastfeeding a baby.

Without a prescription, Lansoprazole should not be administered to people over 18. The recommended initial dose is 30 mg, taken orally once a day for eight weeks.


The maintenance dose for Lansoprazole is 15 mg, once a day. The amount may vary from person to person, depending on your medical condition.


Helicobacter pylori infection

Lansoprazole is used to treat Helicobacter pylori infection in combination with other medicines.

Erosive esophagitis

Lansoprazole is used in the treatment of severe ulcers caused by chronic heartburn.

Multiple endocrine adenomas

Lansoprazole is used to relieve symptoms caused by a tumor in the endocrine system that affects the stomach and intestine.

Systemic mast cell disease

Lansoprazole is also used to relieve the symptoms of a condition in which the mast cells are abnormally high at certain specific sites in the stomach, intestine, and other body parts.

Other forms of ulcers

Lansoprazole is also used to prevent and treat ulcers in the stomach (gastric) and small intestine (duodenal) caused by medications for stress or pain.

In addition to the desired effect, Lansoprazole can also cause some unwanted effects. In such cases, you should seek medical attention immediately. This is not an exhaustive list of side effects. Tell your doctor if you experience any adverse reaction to the medicine:

  • Diarrhea.
  • An allergic reaction of the skin.
  • Severe stomach acne
  • Nausea and vomiting.
  • Symptoms are similar to the flu.
  • Muscle or joint pain.
  • Depression.
  • Unusual bleeding
  • Headache.
  • Flatulence.
  • Inflammation of the face, lips, eyelids, tongue, hands, and feet.
  • Irregular heartbeat.
  • Decreased appetite.

How long can the effect be prolonged?

The effect of this medication lasts an average duration of 24 hours.

What is the beginning of the action?

The effect of this medication can be observed in 1-3 hours after oral administration.

Is there any warning of pregnancy?

Pregnant women can use this medication only when necessary, and the potential benefits outweigh the risks involved.

Consult your doctor before taking this medicine.

Is there any warning when breastfeeding?

Women who breastfeed do not recommend using this medication, as it may cause harm to the baby. However, breastfeeding should be stopped if necessary to use this medication.

Consult your doctor before taking this medicine.

Interaction with the disease

Liver disease

Report any incidence of liver disease to the doctor. Adequate dose adjustment may be necessary depending on the degree of liver failure.


An appropriate adjustment should be made in the dosage and duration of patients at risk of fracture related to osteoporosis. The established treatment guidelines must be followed strictly in such cases.


Report any incidence of imbalance of magnesium level in the body to the doctor. The imbalance can occur due to illness or other medications the patient uses.

Regular monitoring is patched for patients taking Lansoprazole in such cases. Interaction with Alcohol Alcohol Interaction with alcohol is unknown. It is advisable to consult your doctor before consuming it.

Interaction with Medicines

Clopidogrel: Report the use of any of the medications to the doctor. Your doctor may prescribe a safer alternative to reduce your heartburn while being treated with Clopidogrel.

With caution, this medicine should be used with Ketoconazole or other antifungals from the same group. Tell your doctor about using any of these medications so that you can prescribe safer alternatives.

Methotrexate:  The use of any medications should be reported to the doctor so that a safer substitute may be prescribed.

Warfarin: The doctor should monitor the use of Lansoprazole with warfarin. Proper adjustment in dosing and control of Prothrombin time is necessary to ensure safety.

Any symptoms such as unusual bleeding, swelling, vomiting, and blood in the urine should be reported immediately.

Nelfinavir: This medication is not recommended when the patient is already taking antiviral medications such as Nelfinavir or other drugs used to treat HIV infection.

Digoxin:  The prior use of any of these medications should be reported to the doctor. Any symptoms such as nausea, vomiting, diarrhea, loss of appetite, visual disturbances, and abnormalities in a heartbeat should be reported immediately.