Hypoderme: Characteristics, Composition, Efficacy, Precautions, Warnings and Adverse Reactions

The baby’s bottom is subject to high humidity due to the constant presence of feces and urine.

Parents must take the necessary care to prevent chafing (such as taking care of the baby’s tail). The application of anti-chafing cream is controversial; parents can apply it if they notice red or irritated skin.

The hypoderm almonds preventive cream helps to nourish the skin and forms a protective film on the baby’s skin due to its composition of calcitriol, zinc, boric acid, and vitamin A. Because of its chamomile extract, it helps soothe irritated skin.

Hypoderma is a chafing preventive cream specially developed for baby’s skin, with almond oil and chamomile extract. It serves to prevent chafing while hydrating and nourishing the baby’s skin. Among its benefits is:

  • It is hypoallergenic.
  • Contains vitamin A and E.
  • Nourish the baby’s skin.
  • Contains chamomile extract.
  • Clinically and dermatologically tested.
  • Easy to apply and remove.

Apply after washing and drying the tail skin if the skin appears red or irritated. Apply a skinny coat.

This product has been formulated to minimize the possible occurrence of allergies.

Product characteristics

  • Hypoderma is an ointment.
  • It is white to yellowish.
  • It has a characteristic odor.

The product consists of an aqueous phase and fat. Depending on the conditions in which the product is stored or transported, going through drastic temperature changes in a short period, the separation of the two phases can occur.

 

Therefore, in these cases, the 2 phases of the product can be easily noticed. When opening the product, a yellowish liquid may leak out. We inform you that the quality of the product has not been affected and that it can be used commonly.

Composition of hypoderme

The packs contain 1 and 50 tubes with 15, 20, 30, 50, 60, 90, 100, 135 and 150 grams. Each gram of the ointment contains:

  • Palmitato de retinol (vitamina A) 5.000U.I
  • Colecalciferol (vitamina D3) 900U.I
  • Zinc oxide 150mg.
  • QSP receives 1gramo.

Zinc oxide acts as a mechanical protector of the skin barrier; it has no known toxic or adverse effects.

Zinc oxide probably accelerates the healing process by increasing genes’ expression for growth factor IGF-1 (insulin as a growth factor) in granulation tissue.

The action of zinc oxide was demonstrated by stimulating re-epithelialization:

In the basal cells of the epidermis, both intact and non-integral skin of rats, the mitotic index increases when used at a concentration of 25mg. In addition to these effects, it also has an indirect antibacterial impact attributed to zinc oxide, which would be mediated by local defense systems and not by direct action against bacteria.

The application of pure petrolatum on the skin causes a reduction of approximately 50% in the loss of water from the skin, measured after 40 minutes of application, due to the occlusive property of the petrolatum, and results in an emollient action that improves the mechanical barrier function of the skin.

Petrolatum is a highly lipophilic and hydrophobic vehicle that surrounds the latter’s dust particles when associated with zinc oxide, preventing water absorption or exudates.

Preparations containing two immiscible components, such as zinc oxide powder suspended in a lipophilic vehicle such as petrolatum, do not have absorbent characteristics, being highly occlusive.

Petrolatum can be incorporated into the outer layer of the skin’s stratum corneum during the healing process and helps slow down the inflammatory process until the migration of epithelial cells to the surface of the injured skin is complete.

Zinc oxide is an astringent and antiseptic that softens, heals, and protective action on the skin in conditions that present superficial eruptions.

Zinc oxide, vitamin A and associated vitamin D, incorporated into penetrating and moisturizing agents, form a layer that protects the baby’s skin against unwanted chafing.

Cholecalciferol (vitamin D3) and ergocalciferol (vitamin D2) constitute what is known as “vitamin D.” Both compounds are equal in potency and undergo the exact metabolic conversions. There is no difference, both practically and clinically relevant, between them.

Cholecalciferol is a naturally occurring form of vitamin D, produced from 7-dehydrocholesterol, a steroid present in the skin of mammals, in the presence of ultraviolet radiation.

Topically applied vitamin D is used to treat chronic inflammatory diseases such as psoriasis and in healing and skin protection processes, such as healing ointments or chafing, especially when combined with vitamin A.

The formulations must have an oily character, compatible with their fat-soluble characteristics.

Excipients: starch, anhydrous lanolin, white petrolatum, sorbitan monooleate, essence, reverse osmosis water, methylparaben, propylparaben, propylene glycol, and liquid petrolatum.

In addition to the traditional hypoderm and the Omega hypoderm, the Teuto laboratory launches the hypoderm almonds with almond oil and chamomile extract.

Almond hypoderma forms a protective layer on the baby’s skin, avoiding skin contact with feces and pee, and has vitamins A and E, which nourish the baby’s skin and help to leave the baby’s skin always hydrated. And well-nourished.

In its formula, the hypoderm almonds have chamomile extract that has a cooling and healing effect, soothing irritated skin. It is hypoallergenic and is clinically and dermatologically tested.

Hypoderma manufacturer laboratory

Laboratorio Teuto Brasileño SA, also known as Laboratorio Teuto, is a drug factory located in Anápolis, in the state of Goiás. It is considered one of the largest industrial complexes in Brazil and Latin America.

Teuton was the first generic drug industry and the Offshore Technology Conference (OTC) in Brazil to obtain ISO 9000.

In the construction of the Teuton factory, everything was carefully planned and executed to obtain the approval of the Food and Drug Administration (FDA). This agency controls drugs in the United States.

The fact that you can recommend it to develop your commercial activity in world markets, where concern for health-oriented products is accentuated.

The industry produces and sells generic drugs, brand-name generics (similar), MEP (exempt prescription drugs), hospital lines, herbal medicine, food supplements, and cosmetics.

Laboratorio Teuto is within ​​1 million square meters and installed in an area of ​​105 thousand square meters built.

In an area attached to the industry, there is a forest reserve, the Folium Reserve, with 700 thousand square meters, where native fauna and flora of the Cerrado are preserved. In addition, there is a nursery for more than 150 children within the company.

What’s the use of hypoderm

This medicine is intended to protect and treat chafing, and it is made especially for a baby’s sensitive skin. Hypoderma also protects against the action of natural agents such as the sun, wind, dust, seawater, etc.

Apply a layer of hypodermic after each diaper change and always after bathing.

Efficacy results

Several studies indicate that using an ointment or paste containing zinc oxide in its composition gives good results.

The study carried out to evaluate the subclinical alterations in the functions of the corneal layer of the skin with dermatitis during the treatment with the zinc oxide paste and Vaseline showed that the zinc oxide-based preparation reduced the friction force of the skin with the diaper; in addition to also reducing the risk of fungal infection.

The topical application of vitamin D has been linked to increased expression of the antimicrobial peptide LL-37 in human skin.

LL-37 is a predominantly keratinocyte-expressed antimicrobial peptide that performs several functions in skin health, including controlling microbial flora in intact and damaged skin, attracting immune system cells, promoting epithelial repair, and increasing skin angiogenesis required for skin healing.

Decreased expression of various antimicrobial peptides has been reported in certain skin conditions, such as atopic dermatitis and chronic leg ulcers.

Cautions and warnings

You should carefully clean the baby’s skin before applying hypodermic ointment. Do not apply to irritated or damaged skin.

There is insufficient evidence to confirm the occurrence of clinically relevant drug interactions. This medicine is contraindicated in patients with hypersensitivity to any formula’s components.

Do not use the medicine with the expiration date. Store it in its original packaging. Before use, observe the appearance of the treatment. If it is still in the validity period, but you notice any change in appearance, ask your pharmacist to see if you can use it.

All medications must be kept out of the reach of children. When in doubt about this medicine, seek advice from your pharmacist.

Hypoderma storage care

This product must be kept in the cardboard cartridge and stored at room temperature (15ºC to 30ºC) during use. Protect from light and moisture.

Do not use the medicine with the expiration date.

Adverse reactions

Although adverse reactions with hypoderm are rare, itching (itching) or severe redness may occur at the application site.

Report undesirable reactions to the use of the medicine to your doctor.