Hesperidin: Benefits, Uses, Function, Side Effects, Dosage, and Sources of This Glycoside

It is a flavanone glycoside consisting of the flavone hesperetin attached to the disaccharide rutinose.

Sugar causes hesperidin to be more soluble than hesperidin.

Health benefits

  • Hesperidin has antioxidant, anti-inflammatory, lipid-lowering, vasoprotective, anticarcinogenic, and cholesterol-lowering actions.
  • Hesperidin improves capillary health by reducing capillary permeability.
  • It is used to reduce hay fever and other allergic conditions by inhibiting histamine release from mast cells.

The possible anticancer activity of hesperidin could be explained by inhibiting polyamine synthesis.

Use and function

Some drugs move by pumps in cells. Hesperidin can make these pumps less active and increase the amount of some medicines that the body absorbs.

This could increase the amount of some drugs in the body, leading to more side effects. But there is not enough information to know if this is a big concern.

Possibly effective for

Poor circulation in the legs (chronic venous insufficiency): Taking a product containing hesperidin methyl chalcone and oral vitamin C seems to relieve symptoms of poor circulation in the legs.

Additionally, taking a different product containing hesperidin and diosmin by mouth for 2-6 months appears to improve symptoms of chronic venous insufficiency.


Although taking the drug Venoruton might be more effective in treating this condition.

Hemorrhoids: Some research suggests that taking hesperidin and diosmin improves the symptoms of anal hemorrhoids.

It can also prevent hemorrhoids from coming back after they have healed and help in the emergency worsening of hemorrhoids.

Leg ulcers due to poor circulation (venous stasis ulcers): Taking a specific product containing hesperidin and diosmin by mouth for two months seems to improve the healing of small ulcers.

Possibly ineffective for

High cholesterol: Some research shows that taking hesperidin does not affect cholesterol.

Weight loss: Some research shows that taking glucosyl hesperidin for 12 weeks does not reduce body weight in moderately overweight people.

Insufficient evidence

Diabetes: Early research suggests that taking a tablet of a specific product containing hesperidin and diosmin by mouth for 45 days lowers blood sugar levels.

It also improves blood sugar control in women with type 2 diabetes.

High blood pressure:  Early research suggests that taking hesperidin or drinking orange juice that contains hesperidin can lower diastolic blood pressure.

But it does not lower systolic blood pressure in people with or without high blood pressure.

Swelling of the arms (lymphedema):  Taking a specific product containing broom root extract, hesperidin methyl chalcone, and vitamin C for 90 days is said to reduce swelling in the upper arm and forearm.

Improves mobility and heaviness in women with arm swelling after breast cancer treatment.

However, other research shows that taking a different product containing hesperidin and diosmin by mouth does not reduce arm swelling in women after breast cancer surgery.

Rheumatoid Arthritis (RA):  Early research suggests that drinking a beverage containing alpha-glucosyl hesperidin for 12 weeks improves RA symptoms.

Side effects

Hesperidin supplements occasionally cause adverse effects, including nausea, vomiting, diarrhea, and allergic reactions.

Hesperidin is essentially non-toxic and free from interactions with other medications; however, drug interactions can occur if you take it in combination with other bioflavonoids.

When used alone, it is safe for use in pregnant or lactating women. Discuss your medication regimen with your doctor before using bioflavonoid supplements.

Hesperidin is safe for most people when taken by mouth for up to 6 months. The safety of its use over a more extended period is unknown.

Side effects include stomach pain and discomfort, diarrhea, and headache.

Special precautions and warnings

  •  Bleeding disorder: Hesperidin can slow blood clotting and increase the risk of bleeding. In theory, hesperidin could make bleeding disorders worse.
  • Low blood pressure:  can lower blood pressure. In theory, taking hesperidin can make blood pressure drop too low in people who already have low blood pressure.
  • Surgery:  can prolong bleeding. There is concern that hesperidin may increase the risk of bleeding during and after surgical procedures.

Stop taking hesperidin at least two weeks before a scheduled surgery.


The following doses have been studied in scientific research:

For adults

For poor circulation in the legs (chronic venous insufficiency):  a specific combination product is used that contains:

  • Hesperidina metil chalcona 150 mg.
  • Butcher’s Root Root Extract 150 mg.
  • 100 mg of ascorbic acid.

In addition, a combination of 100-150 mg of hesperidin with 900-1350 mg of diosmin taken daily for 2-6 months has been used.

For leg ulcers caused by poor blood circulation (venous stasis ulcers):  a specific combination of 100 mg of hesperidin and 900 mg of diosmin is used daily for up to 2 months.

Besides the compound rutin, hesperidin is the most active bioflavonoid in citrus-based fruits. The bioflavonoid hesperidin helps protect your body from diseases like cancer, circulatory problems, and heart disease.

As a citrus bioflavonoid, hesperidin facilitates the formation of the vitamin C complex, which supports healthy immune system functions.

Hesperidin sources

Supplement manufacturers extract bioflavonoids from citrus fruits. You can get hesperidin and other bioflavonoids in your diet by consuming lemons and oranges; the shell and membranes contain the highest concentration.

Hesperidin is also found in grapefruits, apricots, plums, and blueberries.

Vegetables that contain hesperidin include green and yellow bell peppers and broccoli. Whole grains, like buckwheat, also contain hesperidin.


The phytochemical hesperidin is mainly found in citrus fruits like lemons and oranges.

The highest concentration of hesperidin can be found in citrus peels’ white parts and pulps. Hesperidin can also be found in green vegetables.