Glimepiride: Uses, Administration, Side Effects, Precautions and Storage

This medicine belongs to the class or family of drugs commonly known as sulfonylureas, which reduce the amount of sugar in the body.


It is a drug that is prescribed together with an exercise program and a balanced diet to efficiently control high blood sugar levels caused by type 2 diabetes, releasing the body’s natural insulin.

This medicine allows you to reduce the risk or prevent damage to the body as a result of this condition, such as:

  • Blindness.
  • Kidney damage
  • Loss of bodily limbs.
  • Nervous problems
  • Strokes
  • Heart attacks.

Glimepiride Administration

This medicine should be prescribed by a specialist doctor after evaluating the patient and determining that he needs it to improve his condition, lifestyle, and health.

It is recommended that it be ingested with the first meal of the day, at the same time or as directed by the treating physician.

Dosage may vary depending on the patient’s condition, weight, tolerance to treatment, and how severe or advanced the disease may be.

Side effects

This medicine rarely causes severe side effects, but the patient may have the following symptoms as his body adjusts to the components of the treatment:


  • Stomach ache.
  • Sickness.
  • Dizziness
  • Weightloss.
  • Headache.
  • Hair loss.

If the patient has severe or secondary symptoms such as the following, he should immediately contact his treating doctor:

  • Disorientation.
  • Dark urine
  • Elevated body temperature
  • Yellowish skin or eyes
  • Involuntary movements of the extremities of the body.
  • Throat pain.
  • Mood changes
  • Seizures
  • Unusual weakness
  • Stomach pain or abdominal pain
  • Bleeding through the mucous membranes of the body.
  • Sudden and long-lasting bruising.

The patient must follow the indications provided and not increase the dosage without first being recommended or indicated by the treating physician; otherwise, it may excessively lower blood sugar levels, which can be detrimental to health.

Symptoms of a low blood sugar breakdown are:

  • Cardiac arrhythmia.
  • Sudden and excessive sweating.
  • Trembling in the extremities of the body.
  • Blurred vision or difficulty focusing on objects at short or long distances.
  • Tingling in the hands or feet
  • Frequent dizziness
  • Excessive hunger
  • Chronic tiredness

If the patient presents the mentioned symptoms, they should consume a quick dose of sugar to stabilize their organisms, such as honey, fruit juice, non-diet soft drinks, powdered sugar, or ingest a glucose tablet or gel.

This medicine does not usually cause severe allergic reactions. However, the patient should contact his doctor if he presents the following symptoms:

  • Acne.
  • Redness on the cheekbones of the face.
  • Swelling in the mouth, tongue, and throat.
  • Difficulty breathing.
  • Itching in the extremities of the body.
  • Elevation of body temperature.
  • Cardiac arrhythmia.
  • Severe dizziness

There have been no severe cases where patients overdose on this drug; however, anyone who presents the following symptoms should immediately contact their doctor:

  • Disorientation.
  • Loss of balance
  • Difficulty recognizing space and time.
  • Constant dizziness
  • Cardiac arrhythmia.
  • Loss of appetite
  • Difficulty breathing.
  • Fainting.

Glimepiride Precautions

Before starting treatment with Glimepiride, the patient should notify his doctor if he has suffered or suffered from kidney, liver, thyroid disease, or some condition or hormonal imbalance because this medicine can alter or worsen the disease.

If the patient has symptoms of extraordinarily high or low blood sugar levels, he should avoid activities that merit concentration or that risk his life or that of others until he is sure that he has stabilized, such as:

  • Drive heavy machinery.
  • Drive vehicles.
  • Cook.

While the patient is being treated with Glimepiride, he should avoid consuming alcoholic beverages since they can cause a sudden decrease or increase in blood sugar levels or values.

Women who are in the process of pregnancy should avoid using this drug unless strictly necessary and prescribed by a specialist doctor because it can be harmful to the development of the unborn.

Glimepiride should not be used by breastfeeding women because it is unknown if its components can pass into the milk, which could be harmful to the baby.

Older adults are more likely to suffer from the side effects of this medicine, so they should keep precise control of the treatment and keep in control with their doctor.


This medicine should be kept in room temperature places, away from sunlight, heat, and moisture. Glimepiride does not need to be refrigerated.

It is recommended that it be kept away from contact with children or animals because it can be harmful to their health if ingested without medical supervision. If this happens, you should take the affected person to a specialist to take the appropriate measures.