Garamycin: Indications, Continuity, Uses and How to Manage it

It belongs to the family of medications called antibiotics. They are used to treat infections and are available only with your doctor’s prescription.


To reduce the development of drug-resistant bacteria and maintain the effectiveness of Garamycin and other antibacterial medications, this medication should be used only to treat or prevent infections that are proven or suspected to be caused by susceptible bacteria.

When culture and susceptibility information is available, they should be considered when selecting or modifying antibacterial therapy.

In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empirical selection of therapy.

It is indicated to treat serious infections that were caused by susceptible strains of these microorganisms:

  • Pseudomonas aeruginosa.
  • Proteus species.
  • Escherichia coli.
  • Staphylococcus.

Studies have revealed that Garamycin injection is effective in neonatal bacterial sepsis, bacterial septicemia, and serious bacterial infections of the central nervous system ( meningitis ), urinary tract, respiratory tract, gastrointestinal tract (including peritonitis), skin, bones, and soft tissues (including burns).

Aminoglycosides, including Garamycin, are not indicated in uncomplicated initial episodes of urinary tract infections unless the causative organisms are susceptible to these antibiotics.


Samples should be obtained for bacterial culture to isolate and identify causative organisms and determine their susceptibility to Garamycin.

Garamycin sulfate can be considered first-line therapy in suspected or confirmed Gram-negative infections, and treatment can be initiated even though the susceptibility tests have not yet been obtained.

When to continue treatment?

Continuity with this medication is based on the results of the susceptibility tests, the severity of the infection, and the necessary additional concepts included in the box.

If the causative organisms are resistant to this drug, another appropriate therapy should be instituted.

In infections where the cause is unknown, Garamycin may be administered as initial therapy and, at the same time, a penicillin-like medication before obtaining the results of the susceptibility test.

If there is a suspicion of anaerobic microorganisms as etiological agents, the use of another treatment with Garamycin should be considered.

After identifying the organism and its susceptibility, similar antibiotic therapy should be continued.

This medication has been used successfully with carbenicillin to treat life-threatening infections caused by Pseudomonas aeruginosa.

Garamycin injection has also been shown to treat severe staphylococcal infections effectively.

Although it is not the antibiotic of the first choice, this medication can be considered when penicillins or other less potentially toxic drugs are contraindicated, and bacterial susceptibility tests and clinical judgment indicate their use.

It can also be considered in mixed infections caused by susceptible strains of staphylococci and gram-negative organisms.

In the neonate with suspected bacterial sepsis or staphylococcal pneumonia, a penicillin-like medication is usually indicated as concomitant treatment with Garamycin.


This medicine is used to treat certain serious bacterial infections. It is effective in respiratory tract infections, blood infections, and kidney or bladder infections.

Also, for eye infections, ear infections, burns and wound infections, infections in newborn babies, gynecological disorders, swelling with pus (abscess), and inflammation of the inner layer of the heart ( endocarditis ) due to bacteria.

Garamycin is an aminoglycoside antibiotic used to treat many bacterial infections, particularly those caused by Gram-negative bacteria.

It is one of the few thermostable antibiotics that remain active even after autoclaving, making it particularly useful for preparing certain microbiological growth media.

Treatment of susceptible bacterial infections, usually Gram-negative bacteria that include Pseudomonas, Proteus, and Serratia.

Garamycin is the only heat-stable antibiotic used during orthopedic surgery when high temperatures are required (for example, hip replacements).

How is Garamycin administered?

  • Use the solution as directed by your doctor. Check the medication label to see the exact dosage instructions.
  • The solution is usually an injection in your doctor’s office, hospital, or clinic. If you are going to use Garamicin at home, a doctor should teach you how to use it.
  • Make sure you understand how to use the solution. Follow the procedures you are taught when using a dose. Contact your doctor if you have any questions.
  • Do not use Garamycin solution if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.
  • It is recommended to drink extra fluids while using the solution. Check with your doctor for instructions.
  • Keep this product and syringes and needles out of the reach of children and pets. Do not reuse needles, syringes, or other materials.
  • Ask your doctor how to dispose of these materials after use. Follow all local regulations for disposal.
  • Please do not mix the solution with cephalosporins (for example, cephalothin) or penicillins, as it can inactivate the Garamycin solution.
  • Manage separately. If you miss a dose of the solution, use it as soon as possible. Check with your doctor, pharmacist, or nurse for instructions on programming other doses.
  • Ask your doctor any questions you have about how to use the Garmin solution.