Flonorm: Formula, Indications, Mechanism of Action, Dosage, Side Effects, Warnings, Contraindications and Interactions

The tablets of this medicine contain rifaximin, a non-synthetic (semisynthetic) non-aminoglycoside antibiotic derived from rifamycin.

Rifaximin is a structural analog of rifampicin.

The chemical formula for floor

  • C43H51N3O11.


Flonorm tablets for oral administration contain 200 mg or 550 mg of rifaximin.

The inactive ingredients in each tablet are colloidal silicon dioxide, disodium edetate, glycerol palmitostearate, hypromellose, microcrystalline cellulose, propylene glycol, red iron oxide, sodium starch glycolate, talc, and titanium dioxide.

Indications of flonorm

This medicine treats diarrhea caused by the common bacteria known as E. coli (traveler’s diarrhea). Rifaximin should not be used if you have a fever or bloody diarrhea.

This antibiotic only treats bacterial infections. It will not work for viral infections (like the common cold or flu).

Rifaximin is used to treat irritable bowel syndrome and is also used to prevent a brain problem caused by liver disease ( hepatic encephalopathy ).


Mechanism of action

Rifaximin inhibits bacterial and mycobacterial RNA synthesis by binding to the beta subunit of DNA-dependent RNA polymerase.

In this way, the enzyme’s binding to DNA is inhibited, and the transcription of RNA is blocked.

Rifaximin does not bind to RNA polymerase in eukaryotic cells, so RNA synthesis in human cells is not affected.

For use in treating hepatic encephalopathy, the manufacturer suggests that rifaximin may affect the gastrointestinal flora.

Since oral rifaximin is minimally absorbed, it is concentrated in the gastrointestinal tract, where it exerts its effects.

In general, oral antibiotics have been used for hepatic encephalopathy to reduce ammonia-producing enteric bacteria.


Doses of the floor are based on the patient’s medical condition and response to treatment.

This medication is given by mouth with or without food as directed by your doctor, usually three times a day (every 8 hours) for 3 days to treat traveler’s diarrhea.

To treat irritable bowel syndrome with diarrhea, this medication is given by mouth with or without food as directed by the doctor, usually three times a day for 14 days.

This drug is given by mouth with or without food as directed by your doctor, usually, two times a day (every 12 hours) to prevent hepatic encephalopathy.

Side effects of flonorm

During treatment or weeks or months after treatment has stopped, this drug may cause a severe intestinal condition (Clostridium difficile-associated diarrhea) due to the growth of resistant bacteria.

The doctor should be informed immediately if symptoms such as persistent diarrhea, abdominal or stomach pain, cramps, blood, or mucus in the stool occur.

Do not use antidiarrheal products or narcotic pain medications if you have any of these symptoms because these products can make symptoms worse.

Medical attention should be sought if any symptoms of an allergic reaction are observed, such as rash, itching, swelling mainly of the face, tongue, or throat, severe dizziness, and difficulty breathing.

Warnings and Contraindications

Rifaximin should not be given if you are allergic to rifamycin, rifampin, rifabutin, or any other allergies.

Rifaximin can make live bacterial vaccines, such as typhoid vaccine, not work as well. You should not receive any vaccinations or immunizations while using this medication unless directed to do so by your doctor.

This medicine should only be used during pregnancy and lactation when needed. The risks and benefits should be discussed with the doctor.

Flonorm was not effective in patients with diarrhea complicated by fever, blood in the stool, or diarrhea due to pathogens other than Escherichia coli.

Flonorm should be discontinued if diarrhea symptoms worsen or persist for more than 24 to 48 hours, and alternative antibiotic treatment should be considered.

Flonorm is not practical in cases of traveler’s diarrhea due to Campylobacter jejuni.

The effectiveness of floor in traveler’s diarrhea caused by Shigella spp. and Salmonella spp. It has not been verified.

Flonorm should not be used in patients with Campylobacter jejuni, Shigella spp., or Salmonella spp. It may be suspected of causative pathogens.

Clostridium difficile-associated diarrhea has been reported using nearly all antibacterial agents, including floor, and can range in severity from mild diarrhea to colitis.

Treatment with antibacterial agents disrupts the normal flora of the colon, which can lead to an overgrowth of C. difficile.

Flonorm interactions

Concomitant administration of drugs that are P-glycoprotein inhibitors with the floor can substantially increase the systemic exposure to rifaximin.

Although most antibiotics are unlikely to affect hormonal contraceptives, such as the pills, patches, or rings, some antibiotics (such as rifampin and rifabutin) can decrease their effectiveness.