Dipirona: What is it? Indications, Uses, Presentations, Side Effects and Warnings

It is an analgesic and antipyretic of the pyrazolone group.

Indications and use

Metamizole (dipyrone) belongs to medicines called analgesics and antipyretics.

This medication is used to treat acute postoperative or post-traumatic pain, colicky pain, and pain of a tumor origin. It is also used in cases of a high fever that do not respond to other antipyretics.

It is recommended to consult your doctor if you are not sure (or do not know) why you have been given metamizole (dipyrone).



The active substance is metamizole sodium. The other ingredients (excipients) are corn starch, sodium bicarbonate, lactose, talc, and magnesium stearate.


The active substance is magnesium metamizole. The other ingredients are magnesium stearate, indigotin, erythrosine, titanium dioxide, and gelatin.


Each sachet contains 1 or 2 g of magnesium metamizole. The excipients are sodium saccharin, mannitol, povidone K29 / 32, orange flavor, and orange-yellow dye.



Metamizole, non-pyrogenic distilled water. Some specialties contain metamizole sodium.


The active substance is magnesium metamizole. Each suppository contains 500 mg or 1000 mg of magnesium metamizole. The other component is triglycerides of fatty acids.


The composition of the various presentations may vary from one country to another. We recommend that you check the information provided by your local provider.

Side effects of Dipyrone


This medicine in tablets contains lactose. If your doctor has told you that you have an intolerance to certain sugars, contact him before taking it.


Some specialties contain orange-yellow dye as an excipient. It can cause allergic reactions, including asthma, especially in patients allergic to aspirin.

Some specialties contain

  • Glycerol: can be harmful in high doses. It can cause headaches, upset stomach, and diarrhea.
  • Sorbitol: may cause upset stomach and diarrhea. Do not use in patients with hereditary fructose intolerance.

Before taking dipyrone

Do not use metamizole (dipyrone).

If you are allergic (hypersensitive) to metamizole (dipyrone), other pyrazolone derivatives, or any other ingredients of the medicine prescribed for you.

If you think you may be allergic, consult your doctor.

Allergy symptoms may include:

  • Asthma attacks with difficulty breathing, audible wheezing, or rapid breathing.
  • More or less sudden swelling of the face, lips, tongue, or another body part. It is especially critical if it affects the vocal cords.
  • Urticaria, itching, rash.
  • Anaphylactic shock loss of consciousness, pallor, sweating, etc.

You should not take this medicine either:

  • If you have had a decrease in the number of white blood cells (agranulocytosis) after using this substance.
  • If you have had asthma, rhinitis, or urticaria (red spots or hives on the skin that can cause itching) after aspirin, paracetamol, or nonsteroidal anti-inflammatory drugs (NSAIDs) as there may be cross-sensitivity.
  • If you suffer from acute intermittent porphyria (a disorder of the metabolism of blood pigments part of hemoglobin).
  • If your doctor has not prescribed this medication.
  • If you have a congenital deficiency of glucose 6-phosphate dehydrogenase.
  • If you have had a disorder of bone marrow function, for example, after chemotherapy, or if you have had blood diseases.

Take special care with metamizole (dipyrone)

If you have signs or symptoms that suggest:

  • Anaphylaxis.
  • Anaphylactic shock.
  • Dizziness
  • Difficulty breathing.
  • Rhinitis.
  • Swelling of the face (angioneurotic edema).
  • It decreased blood pressure.
  • Red spots on the skin of sudden onset of high fever.
  • I am shaking chills.
  • Sore throat.
  • Pain in the mouth
  • Sores on the oral or genital mucosa could decrease white blood cells (agranulocytosis).

In these cases, you should stop the treatment and consult your doctor immediately.

If you have had an allergic reaction to metamizole, you should not take a medicine that contains it again.

If you have asthma produced by analgesics, bronchial asthma, chronic urticaria, or if it is intolerant to dyes and preservatives or alcohol since the risk of potentially severe allergic reactions is more significant.

If you have pre-existing low blood pressure (below 100 mmHg), unstable circulation, or a high fever, an increased risk of an acute decrease in blood pressure.

If you have impaired kidney or liver function.