Index
With burns, the drug tends to reduce the spread of necrosis in depth and promote healing of burned skin surfaces.
Dermazin or Dermazina, is an antibacterial drug used for external use in the prevention and treatment of infections from burns, wounds and trophic ulcers.
The drug is active against almost all microbes that cause skin wound infection such as Escherichia coli, Pseudomonas aeruginosa, Staphylococcus spp., Proteus spp., Streptococcus spp., Enterobacter spp. and Klebsiella spp.
Some strains of the herpes virus and yeast fungi (Candida albicans).
Chemical formula
- C10H9AgN4O2S.
Presentation
Dermazin is available in the form of a 50 g cream, for external use at 1%, whose active ingredient is microcrystalline silver sulfadiazine.
As auxiliary substances in the cream are used: polysorbate 60, ethyl alcohol, propylene glycol, hydrogenated peanut oil, methylhydroxybenzoate, purified water, propylhydroxybenzoate.
The preparation is produced in 250 g containers or in 50 g tubes.
Indications
According to the instructions, Dermazin is used for the prevention and treatment of burn infections (even before autodermoplasty), wound infection, and trophic ulcers.
Mechanism of action
Dermazin improves the patient’s condition by inhibiting the growth of bacteria.
Dose
Dermazin cream is used only for external use, after surgical treatment of the wound surface, the cream should be applied in a layer of 2 to 4 mm approximately 1 to 2 times a day.
The cream can be applied under bandages or even used without them.
While applying the cream under the bandage, it should be changed every day.
Treatment continues until the wound is completely healed.
Side effects
When using Dermazin, side effects such as:
A skin reaction: such as itching or a burning sensation.
The hematopoiesis system: transient leukopenia (the maximum decrease in the number of leukocytes occurs within 2 to 4 days after the start of therapy, then their level returns to normal in 2 to 3 days, regardless of whether the treatment continue with the drug or not).
Also agranulocytosis, thrombocytopenia, aplastic anemia or hemolytic anemia.
Others: skin necrosis, erythema multiforme, interstitial nephritis, skin pigmentation disorders, dyspeptic phenomena, toxic nephrosis, hepatocellular necrosis, hepatitis, allergic reactions, reactions in the central nervous system.
Warnings and Contraindications
According to the instructions, Dermazin should not be applied:
- When there is an increased sensitivity of the patient’s body to sulfonamides.
- When there is a greater sensitivity of the patient’s body to any of the components of the drug.
- In preterm infants.
- In babies up to 2 months of age.
- During delivery or when pregnancy is suspected, you should consult your doctor.
When using Dermazin, it should be noted that:
- During treatment, the development of superinfection is possible.
- The drug is prescribed with caution to patients with congenital glucose-6-phosphate dehydrogenase insufficiency.
- The drug is prescribed with caution to patients with impaired kidney or liver function due to an increased risk of accumulation of the drug due to delayed excretion from the body. When treating a drug with this category of patients, it is necessary to regularly monitor the level of sulfadiazine in the serum.
- With prolonged use of the cream on large surfaces, it is necessary to monitor the blood formula due to the risk of developing thrombocytopenia, leukopenia, eosinophilia.
- When applying the cream to large wound surfaces, it is necessary to monitor kidney function, the level of sulfadiazine in serum and urine.
- Dermazin should not be allowed to get into the eyes.
- The drug is not used in cases of porphyria.
- During pregnancy, Dermazine is not used, except when the possible benefit to the mother outweighs the risk to the health of the fetus (especially in the third trimester of pregnancy and during delivery).
- If it is necessary to use the cream while breastfeeding, breastfeeding should be discontinued due to the risk of side effects in the child.
Interactions
- Dermazin can inactivate the enzyme preparations used to clean the wound.
- When the drug is used simultaneously with cimetidine, the risk of leukopenia increases.
